Rapid computation of large numbers of LOD scores in linkage analysis through polynomial expression of genetic likelihoods

Proceedings - 2007 IEEE International Conference on Bioinformaticsand Biomedicine Workshops, BIBMW

Volumn , Issue , 2007, Pages 197-204

  Wang, Hongling ^a   Huang, Yungui ^a   Segre, Alberto Maria ^b   O'Connell, Jeffrey R ^c   Vieland, Veronica J ^d  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b University of Iowa   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPLIED (CO); COMPUTING EFFICIENCY; EVALUATION STRATEGIES; GENETIC LINKAGE; GENETIC LINKAGE ANALYSIS; GENETIC PARAMETERS; INTERNATIONAL CONFERENCES; LIKELIHOOD RATIO (LR); LINKAGE ANALYSIS; NEW METHODS; PARAMETER VALUES; PEDIGREE DATA; POLYNOMIAL EVALUATIONS; POLYNOMIAL EXPRESSIONS; POSTERIOR PROBABILITIES; RECOMPUTATION; SPECIFIC PARAMETER VALUES; SPEED UPS;

BIOCOMMUNICATIONS; BIOINFORMATICS; CALCULATIONS; COMPUTATIONAL METHODS; INFORMATION SCIENCE; MAXIMUM LIKELIHOOD ESTIMATION; NUMBER THEORY; NUMERICAL METHODS; POLYNOMIAL APPROXIMATION; RISK ASSESSMENT;

POLYNOMIALS;

EID: 44949248221     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/BIBMW.2007.4425419     Document Type: Conference Paper

References (6)

1. F Clerget-Darpoux, C. Bonaiti-Pellie, and J. Hoches. Effects of misspecifying genetic parameters in lod score analysis. Biometrics, pages 393-399, 1986.
2. R. C. Elston and J. Stewart. A general model for the genetic analysis of pedigree data. Human Heredity, pages 523-542, 1971.
3. Y. Huang, A. Segre, J. O'Connell, H. Wang, and V. Vieland. A 2nd generation distributed multiprocessor linkage and linkage disequilibrium analysis program. Annual Meeting of American Society of Human Genetics, (A1556), 2006.
4. V. Vieland. Bayesian linkage analysis, or: How I learned to stop worrying and love the posterior probability of linkage. American Journal of Human genetics, pages 947-954, 1998.
5. H. Wang, A. Segre, Y. Huang, J. O'Connell, and V. Vieland. Fast computation of large numbers of lod scores for genetic linkage analysis via a novel polynomial implementation. Annual Meeting of American Society of Human Genetics, (A2308), 2006.
6. H. Wang, A. Segre, Y. Huang, J. O'Connell, and V. Vieland. Fast computation of human genetic linkage. submitted to IEEE 7th International Symposium on BioInformatics and BioEngineering, October 2007.