Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2

American Journal of Physiology - Renal Physiology

Volumn 294, Issue 4, 2008, Pages

  Kim, Gheun Ho ^a,b   Nak, Won Choi ^c   Jung, Ju Young ^d   Song, Ji Hyun ^d   Chang, Hwa Lee ^a   Chong, Myung Kang ^a   Knepper, Mark A ^e  

^a Hanyang University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c Konyang University College of Medicine   (South Korea)

^d Chungnam National University   (South Korea)

^e Laboratory of Kidney and Electrolyte Metabolism NHBLI   (United States)

Author keywords

Aquaporin 2; Cyclooxygenase 2; DFU; Lithium; Na K 2Cl cotransporter

Indexed keywords

5,5 DIMETHYL 3 (3 FLUOROPHENYL) 4 (4 METHANESULFONYLPHENYL) 2(5H) FURANONE; AQUAPORIN 2; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LITHIUM; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; 3 (3 FLUOROPHENYL) 5,5 DIMETHYL 4 (4 METHYLSULFONYLPHENYL) 2(5H) FURANONE; 5,5-DIMETHYL-3-(3-FLUOROPHENYL)-4-(4-METHYLSULFONYL)PHENYL-2(5H)-FURANONE; ANTIDIURETIC AGENT; AQP2 PROTEIN, RAT; FURAN DERIVATIVE; PROSTAGLANDIN E2; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2 PROTEIN; SODIUM-POTASSIUM CHLORIDE COTRANSPORTER 2 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; POLYURIA; PRIORITY JOURNAL; RAT; UPREGULATION; URINE OSMOLALITY; ANIMAL; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIDIURETIC AGENTS; AQUAPORIN 2; CYCLOOXYGENASE 2 INHIBITORS; DIABETES INSIPIDUS, NEPHROGENIC; DINOPROSTONE; FURANS; MALE; POLYURIA; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 44949231366     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00366.2007     Document Type: Article

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