Distribution and expression levels of somatostatin and somatostatin receptors in the ileum of normal and acutely Schistosoma mansoni-infected SSTR2 knockout/lacZ knockin mice

Neurogastroenterology and Motility

Volumn 20, Issue 7, 2008, Pages 798-807

  Van Op Den Bosch, J ^a   Lantermann, K ^a   Torfs, P ^a   Van Marck, E ^b   Van Nassauw, L ^a,b   Timmermans, J P ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Intestinal inflammation; Mast cell; Somatostatin; Somatostatin receptor; SSTR2 knockout mouse

Indexed keywords

MESSENGER RNA; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LOCALIZATION; FEMALE; HISTOPATHOLOGY; ILEUM; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; INTESTINE INNERVATION; KNOCKOUT MOUSE; MALE; MAST CELL; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; WILD TYPE;

ANIMALS; FEMALE; ILEUM; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, SOMATOSTATIN; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SOMATOSTATIN;

EID: 44949202375     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01088.x     Document Type: Article

References (30)

1. Grider JR. Neurotransmitters mediating the intestinal peristaltic reflex in the mouse. J Pharmacol Exp Ther 2003 307 : 460 7.
2. Sternini C, Wong H, Wu SV et al. Somatostatin 2A receptor is expressed by enteric neurons and by interstitial cells of Cajal and enterochromaffin-like cells of the gastrointestinal tract. J Comp Neurol 1997 386 : 396 408.
3. Allen JP, Canty AJ, Schulz S, Humphrey PP, Emson PP, Young HM. Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice. J Comp Neurol 2002 454 : 329 40.
4. De Jonge F, Van Nassauw L, De Man JG et al. Effects of Schistosoma mansoni infection on somatostatin and somatostatin receptor 2A expression in mouse ileum. Neurogastroenterol Motil 2003 15 : 149 59.
5. Van Op den bosch J, Van Nassauw L, Lantermann K, Van Marck E, Timmermans JP. Effect of intestinal inflammation on the cell-specific expression of somatostatin receptor subtypes in the murine ileum. Neurogastroenterol Motil 2007 19 : 596 606.
6. Abdu F, Hicks GA, Henning G, Allen JP, Grundy D. Somatostatin sst2 receptors inhibit peristalsis in the rat and mouse jejunum. Am J Physiol 2002 282 : G624 33.
7. O'Donnell LJD, Watson AJM, Cameron D, Farthing MJ. Effect of octreotide on mouth- to-caecum transit time in healthy subjects and in the irritable bowel syndrome. Aliment Pharmacol Ther 1990 4 : 177 82.
8. O'Keefe SJ, Haymond MW, Bennet WM, Oswald B, Nelson DK, Shorter RG. Long-acting somatostatin analogue therapy and protein metabolism in patients with jejunostomies. Gastroenterology 1994 107 : 379 88.
9. Von der Ohe MR, Camilleri M, Thomforde GM, Klee GG. Differential regional effects of octreotide on human gastrointestinal motor function. Gut 1995 36 : 743 8.
10. Piqueras L, Tache Y, Martinez V. Somatostatin receptor type 2 mediates bombesin-induced inhibition of gastric acid secretion in mice. J Physiol 2003 549 : 889 901.
11. Piqueras L, Martinez V. Role of somatostatin receptors on gastric acid secretion in wild-type and somatostatin receptor 2 knockout mice. Naunyn Schmiedebergs Arch Pharmacol 2004 370 : 510 20.
12. Casini G, Dal Monte M, Petrucci C et al. Altered morphology of rod bipolar axonal terminals in the retinas of mice carrying genetic deletion of somatostatin subtype receptor 1 or 2. Eur J Neurosci 2004 19 : 43 54.
13. Elliott DE, Metwali A, Blum AM, Sandor M, Lynch R, Weinstock JV. T lymphocytes isolated from the hepatic granulomas of schistosome-infected mice express somatostatin receptor subtype II (SSTR2) messenger RNA. J Immunol 1993 153 : 1180 6.
14. Elliott DE, Li J, Blum AM, Metwali A, Patel YC, Weinstock JV. SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-γ release. Eur J Immunol 1999 29 : 2454 63.
15. Akgul S, Erbil Y, Giris M et al. The effect of octreotide on pancreatic damage in TNBS-induced colitis. Surg Innov 2006 13 : 102 8.
16. Mallas E, Karamanolis G, Zissis M et al. Photodynamic therapy in normal pig stomach: protective effect of octreotide. Endoscopy 2004 36 : 893 7.
17. Olgac V, Erbil Y, Barbaros U et al. The efficacy of octreotide in pancreatic and intestinal changes: radiation-induced enteritis in animals. Dig Dis Sci 2006 51 : 227 32.
18. Helyes Z, Pintér E, Németh J et al. Anti-inflammatory effect of synthetic somatostatin analogues in the rat. Br J Pharmacol 2001 134 : 1571 9.
19. Helyes Z, Pintér E, Németh J et al. Effects of the somatostatin receptor subtype 4 selective agonist J-2156 on sensory neuropeptide release and inflammatory reactions in rodents. Br J Pharmacol 2006 149 : 405 15.
20. Allen JP, Hathway GJ, Clarke NJ et al. Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of action within the striatum. Eur J Neurosci 2003 17 : 1881 95.
21. Smithers SR, Terry RJ. The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 1965 55 : 695 700.
22. Bogers J, Moreels T, De Man J et al. Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine. Neurogastroenterol Motil 2000 12 : 431 40.
23. Shindler KS, Roth KA. Double immunofluorescent staining using two unconjugated primary antisera raised in the same species. J Histochem Cytochem 1996 44 : 1131 335.
24. Ramirez JL, Mouchantaf R, Kumar U et al. Brain somatostatin receptors are up-regulated in somatostatin-deficient mice. Mol Endocrinol 2002 16 : 1951 63.
25. Ramirez JL, Grant M, Norman M et al. Deficiency of somatostatin (SST) receptor type 5 (SSTR5) is associated with sexually dimorphic changes in the expression of SST and SST receptors in brain and pancreas. Mol Cell Endocrinol 2004 221 : 105 19.
26. Van Nassauw L, Bogers J, Van Marck E, Timmermans JP. Role of reactive nitrogen species in neuronal cell damage during intestinal schistosomiasis. Cell Tissue Res 2001 303 : 329 36.
27. Wood JD. Enteric neuroimmunophysiology and pathophysiology. Gastroenterology 2004 127 : 635 57.
28. Rong W, Winchester WJ, Grundy D. Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor. J Physiol 2007 581 (Pt 2 779 86.
29. Videau C, Hochgeschwender U, Kreienkamp HJ et al. Characterisation of [125I]- Tyr0Trp8-somatostatin binding in sst1- to sst4- and SRIF-gene- invalidated mouse brain. Naunyn Schiemedebergs Arch Pharmacol 2003 376 : 562 71.
30. Hannon JP, Petrucci C, Fehlmann D, Viollet C, Epelbaum J, Hoyer D. Somatostatin sst2 receptor knock-out mice: localisation of sst1-5 receptor mRNA and binding in mouse brain by semi-quantitative RT-PCR, in situ hybridisation histochemistry and receptor autoradiography. Neuropharmacology 2002 42 : 396 413.