An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity

Toxicology and Applied Pharmacology

Volumn 230, Issue 1, 2008, Pages 126-134

  Aleo, Michael D ^a   Doshna, Colleen M ^a   Fritz, Carol A ^a  

^a PFIZER INC   (United States)

Author keywords

Cyclosporine A; GFR; Glomerular filtration rate; Hepatic; Hepatobiliary; Leukotriene; LTC4; LTD4, Thromboxane; Nephrotoxicity; Renal; Toxicity; TXA2; TXB2

Indexed keywords

CYCLOSPORIN A; LEUKOTRIENE C4; PEPTIDOLEUKOTRIENE; THROMBOXANE A2;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; BILE FLOW; BILIARY EXCRETION; CANNULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG MECHANISM; DRUG METABOLISM; GLOMERULUS FILTRATION RATE; HEPATOBILIARY DISEASE; JUGULAR VEIN; KIDNEY FUNCTION; KIDNEY PARENCHYMA; MALE; MICTURITION; NEPHROTOXICITY; NONHUMAN; RAT; SINGLE DRUG DOSE; URINARY EXCRETION;

ANIMALS; BILIARY TRACT; CYCLOSPORINE; GLOMERULAR FILTRATION RATE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; LEUKOTRIENE C4; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; THROMBOXANES;

RATTUS;

EID: 44949201127     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.02.011     Document Type: Article

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