Evidence-based pragmatic guidelines for the follow-up of testicular cancer: Optimising the detection of relapse

British Journal of Cancer

Volumn 98, Issue 12, 2008, Pages 1894-1902

  Van As, N J ^a   Gilbert, D C ^a   Money Kyrle, J ^b   Bloomfield, D ^c   Beesley, S ^d   Dearnaley, D P ^a   Horwich, A ^a   Huddart, R A ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b ROYAL SURREY COUNTY HOSPITAL   (United Kingdom)

^c ROYAL SUSSEX COUNTY HOSPITAL   (United Kingdom)

^d Kent Cancer Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RELAPSE; EVIDENCE BASED MEDICINE; FOLLOW UP; GERM CELL TUMOR; HUMAN; NON SEMINOMATOUS GERMINOMA; PRACTICE GUIDELINE; PRIORITY JOURNAL; RELIABILITY; REVIEW; RISK BENEFIT ANALYSIS; SEMINOMA; TESTIS CANCER;

ADOLESCENT; ADULT; COMBINED MODALITY THERAPY; EVIDENCE-BASED MEDICINE; FOLLOW-UP STUDIES; HUMANS; MALE; PRACTICE GUIDELINES AS TOPIC; RECURRENCE; TESTICULAR NEOPLASMS;

EID: 44949179724     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604280     Document Type: Review

References (76)

1. International Germ Cell Cancer Collaborative Group (1997) International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol 15: 594-603
2. Ackers C, Rustin GJ (2006) Lactate dehydrogenase is not a useful marker for relapse in patients on surveillance for stage I germ cell tumours. Br J Cancer 94: 1231-1232
3. Albers P, Melchior D, Muller SC (2003) Surgery in metastatic testicular cancer. Eur Urol 44: 233-244
4. Arranz Arija JA, Garcia del Muro X, Guma J, Aparicio J, Salazar R, Saenz A, Carles J, Sanchez M, Germa-Lluch JR (2001) E400P in advanced seminoma of good prognosis according to the International Germ Cell Cancer Collaborative Group (IGCCCG) classification: the Spanish Germ Cell Cancer Group experience. Ann Oncol 12: 487-491
5. Atsu N, Eskicorapci S, Uner A, Ekici S, Gungen Y, Erkan I, Uygur MC, Ozen H (2003) A novel surveillance protocol for stage I nonseminomatous germ cell testicular tumours. BJU Int 92: 32-35
6. Bergstrom R, Adami HO, Mohner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Akre O, Hakulinen T (1996) Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J Natl Cancer Inst 88: 727-733
7. Boice Jr JD, Preston D, Davis FG, Monson RR (1991) Frequent chest X-ray fluoroscopy and breast cancer incidence among tuberculosis patients in Massachusetts. Radiat Res 125: 214-222
8. Brenner DJ (2004) Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer. Radiology 231: 440-445
9. Brydoy M, Fossa SD, Klepp O, Bremnes RM, Wist EA, Wentzel-Larsen T, Dahl O (2005) Paternity following treatment for testicular cancer. J Natl Cancer Inst 97: 1580-1588
10. Choo R, Thomas G, Woo T, Lee D, Kong B, Iscoe N, Danjoux C, Klotz L, Morton G, Chander S (2005) Long-term outcome of postorchiectomy surveillance for Stage I testicular seminoma. Int J Radiat Oncol Biol Phys 61: 736-740
11. Chung P, Parker C, Panzarella T, Gospodarowicz MK, Jewett S, Milosevic MF, Catton CN, Bayley AJ, Tew-George B, Moore M, Sturgeon JF, Warde P (2002) Surveillance in stage I testicular seminoma - risk of late relapse. Can J Urol 9: 1637-1640
12. Chung PW, Gospodarowicz MK, Panzarella T, Jewett MA, Sturgeon JF, Tew-George B, Bayley AJ, Catton CN, Milosevic MF, Moore M, Warde PR (2004) Stage II testicular seminoma: patterns of recurrence and outcome of treatment. Eur Urol 45: 754-759; discussion 759-760
13. Classen J, Schmidberger H, Meisner C, Souchon R, Sautter-Bihl ML, Sauer R, Weinknecht S, Kohrmann KU, Bamberg M (2003) Radiotherapy for stages IIA/B testicular seminoma: final report of a prospective multicenter clinical trial. J Clin Oncol 21: 1101-1106
14. Cullen MH, Stenning SP, Parkinson MC, Fossa SD, Kaye SB, Horwich AH, Harland SJ, Williams MV, Jakes R (1996) Short-course adjuvant chemotherapy in high-risk stage I nonseminomatous germ cell tumors of the testis: a Medical Research Council report. J Clin Oncol 14: 1106-1113
15. Dahl AA, Bremnes R, Dahl O, Klepp O, Wist E, Fossa SD (2007) Is the sexual function compromised in long-term testicular cancer survivors? Eur Urol 52: 1438-1447
16. Dalal PU, Sohaib SA, Huddart R (2006) Imaging of testicular germ cell tumours. Cancer Imaging 6: 124-134
17. Daugaard G, Petersen PM, Rorth M (2003) Surveillance in stage I testicular cancer. APMIS 111: 76-83; discussion 83-85
18. De Santis M, Becherer A, Bokemeyer C, Stoiber F, Oechsle K, Sellner F, Lang A, Kletter K, Dohmen BM, Dittrich C, Pont J (2004) 2-18fluorodeoxy- D-glucose positron emission tomography is a reliable predictor for viable tumor in postchemotherapy seminoma: an update of the prospective multicentric SEMPET trial. J Clin Oncol 22: 1034-1039
19. de Wit R, Roberts JT, Wilkinson PM, de Mulder PH, Mead GM, Fossa SD, Cook P, de Prijck L, Stenning S, Collette L (2001) Equivalence of three or four cycles of bleomycin, etoposide, and cisplatin chemotherapy and of a 3- or 5-day schedule in good-prognosis germ cell cancer: a randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group and the Medical Research Council. J Clin Oncol 19: 1629-1640
20. Dieckmann KP, Albers P, Classen J, De Wit M, Pichlmeier U, Rick O, Mullerleile U, Kuczyk M (2005) Late relapse of testicular germ cell neoplasms: a descriptive analysis of 122 cases. J Urol 173: 824-829
21. Dieckmann KP, Bruggeboes B, Pichlmeier U, Kuster J, Mullerleile U, Bartels H (2000) Adjuvant treatment of clinical stage I seminoma: is a single course of carboplatin sufficient? Urology 55: 102-106
22. Divrik RT, Akdogan B, Ozen H, Zorlu F (2006) Outcomes of surveillance protocol of clinical stage I nonseminomatous germ cell tumors - is shift to risk adapted policy justified? J Urol 176: 1424-1429; discussion 1429-1430
23. Donohue JP, Thornhill JA, Foster RS, Rowland RG, Bihrle R (1993) Retroperitoneal lymphadenectomy for clinical stage A testis cancer (1965-1989): modifications of technique and impact on ejaculation. J Urol 149: 237-243
24. Fleer J, Hoekstra HJ, Sleijfer DT, Tuinman MA, Klip EC, Hoekstra-Weebers JE (2006) Quality of life of testicular cancer survivors and the relationship with sociodemographics, cancer-related variables, and life events. Support Care Cancer 14: 251-259
25. Fossa SD (2004) Long-term sequelae after cancer therapy - survivorship after treatment for testicular cancer. Acta Oncol 43: 134-141
26. Fossa SD, Chen J, Schonfeld SJ, McGlynn KA, McMaster ML, Gail MH, Travis LB (2005) Risk of contralateral testicular cancer: a population-based study of 29,515 U.S. men. J Natl Cancer Inst 97: 1056-1066
27. Fossa SD, Horwich A, Russell JM, Roberts JT, Cullen MH, Hodson NJ, Jones WG, Yosef H, Duchesne GM, Owen JR, Grosch EJ, Chetiyawardana AD, Reed NS, Widmer B, Stenning SP (1999a) Optimal planning target volume for stage I testicular seminoma: a Medical Research Council randomized trial. Medical Research Council Testicular Tumor Working Group. J Clin Oncol 17: 1146
28. Fossa SD, Stenning SP, Gerl A, Horwich A, Clark PI, Wilkinson PM, Jones WG, Williams MV, Oliver RT, Newlands ES, Mead GM, Cullen MH, Kaye SB, Rustin GJ, Cook PA (1999b) Prognostic factors in patients progressing after cisplatin-based chemotherapy for malignant nonseminomatous germ cell tumours. Br J Cancer 80: 1392-1399
29. Freedman LS, Parkinson MC, Jones WG, Oliver RT, Peckham MJ, Read G, Newlands ES, Williams CJ (1987) Histopathology in the prediction of relapse of patients with stage I testicular teratoma treated by orchidectomy alone. Lancet 2: 294-298
30. Gietema JA, Meinardi MT, Sleijfer DT, Hoekstra HJ, van der Graaf WT (2002) Routine chest X-rays have no additional value in the detection of relapse during routine follow-up of patients treated with chemotherapy for disseminated non-seminomatous testicular cancer. Ann Oncol 13: 1616-1620
31. Gietema JA, Sleijfer DT, Willemse PH, Schraffordt Koops H, van Ittersum E, Verschuren WM, Kromhout D, Sluiter WJ, Mulder NH, de Vries EG (1992) Long-term follow-up of cardiovascular risk factors in patients given chemotherapy for disseminated nonseminomatous testicular cancer. Ann Intern Med 116: 709-715
32. Harland SJ, Cook PA, Fossa SD, Horwich A, Mead GM, Parkinson MC, Roberts JT, Stenning SP (1998) Intratubular germ cell neoplasia of the contralateral testis in testicular cancer: defining a high risk group. J Urol 160: 1353-1357
33. Harvey ML, Geldart TR, Duell R, Mead GM, Tung K (2002) Routine computerised tomographic scans of the thorax in surveillance of stage I testicular non-seminomatous germ-cell cancer - a necessary risk? Ann Oncol 13: 237-242
34. Hoei-Hansen CE, Nielsen JE, Almstrup K, Hansen MA, Skakkebaek NE, Rajpert-DeMeyts E, Leffers H (2004) Identification of genes differentially expressed in testes containing carcinoma in situ. Mol Hum Reprod 10: 423-431
35. Hoffman DA, Lonstein JE, Morin MM, Visscher W, Harris III BS, Boice Jr JD (1989) Breast cancer in women with scoliosis exposed to multiple diagnostic x rays. J Natl Cancer Inst 81: 1307-1312
36. Holm M, Hoei-Hansen CE, Rajpert-De Meyts E, Skakkebaek NE (2003) Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle. J Urol 170: 1163-1167
37. Horwich A (2002) Testicular Tumours, vol 2, Oxford Textbook of Oncology. Oxford University Press: Oxford
38. Horwich A, Shipley J, Huddart R (2006) Testicular germ-cell cancer. Lancet 367: 754-765
39. Huddart RA, Birtle AJ (2005) Recent advances in the treatment of testicular cancer. Expert Rev Anticancer Ther 5: 123-138
40. Huddart RA, Joffe JK (2006) Preferred treatment for stage I seminoma: a survey of Canadian radiation oncologists. Clin Oncol (R Coll Radiol) 18: 693-695
41. Huddart RA, Norman A, Moynihan C, Horwich A, Parker C, Nicholls E, Dearnaley DP (2005) Fertility, gonadal and sexual function in survivors of testicular cancer. Br J Cancer 93: 200-207
42. Huddart RA, Norman A, Shahidi M, Horwich A, Coward D, Nicholls J, Dearnaley DP (2003) Cardiovascular disease as a long-term complication of treatment for testicular cancer. J Clin Oncol 21: 1513-1523
43. Jones WG, Fossa SD, Mead GM, Roberts JT, Sokal M, Horwich A, Stenning SP (2005) Randomized trial of 30 versus 20 Gy in the adjuvant treatment of stage I testicular seminoma: a report on Medical Research Council Trial TE18, European Organisation for the Research and Treatment of Cancer Trial 30942 (ISRCTN18525328). J Clin Oncol 23: 1200-1208
44. Kondagunta GV, Sheinfeld J, Motzer RJ (2003) Recommendations of follow-up after treatment of germ cell tumors. Semin Oncol 30: 382-389
45. Livsey JE, Taylor B, Mobarek N, Cooper RA, Carrington B, Logue JP (2001) Patterns of relapse following radiotherapy for stage I seminoma of the testis: implications for follow-up. Clin Oncol (R Coll Radiol) 13: 296-300
46. Martin JM, Panzarella T, Zwahlen DR, Chung P, Warde P (2007) Evidence-based guidelines for following stage 1 seminoma. Cancer 109: 2248-2256
47. Mead GM, Stenning SP, Parkinson MC, Horwich A, Fossa SD, Wilkinson PM, Kaye SB, Newlands ES, Cook PA (1992) The Second Medical Research Council study of prognostic factors in nonseminomatous germ cell tumors. Medical Research Council Testicular Tumour Working Party. J Clin Oncol 10: 85-94
48. Nuver J, Smit AJ, Wolffenbuttel BH, Sluiter WJ, Hoekstra HJ, Sleijfer DT, Gietema JA (2005) The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer. J Clin Oncol 23: 3718-3725
49. Oldenburg J, Martin JM, Fossa SD (2006) Late relapses of germ cell malignancies: incidence, management, and prognosis. J Clin Oncol 24: 5503-5511
50. Oliver RT, Mason MD, Mead GM, von der Maase H, Rustin GJ, Joffe JK, de Wit R, Aass N, Graham JD, Coleman R, Kirk SJ, Stenning SP (2005) Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial. Lancet 366: 293-300
51. Oliver RT, Ong J, Shamash J, Ravi R, Nagund V, Harper P, Ostrowski MJ, Sizer B, Levay J, Robinson A, Neal DE, Williams M (2004) Long-term follow-up of Anglian Germ Cell Cancer Group surveillance versus patients with Stage 1 nonseminoma treated with adjuvant chemotherapy. Urology 63: 556-561
52. Patterson H, Norman AR, Mitra SS, Nicholls J, Fisher C, Dearnaley DP, Horwich A, Mason MD, Huddart RA (2001) Combination carboplatin and radiotherapy in the management of stage II testicular seminoma: comparison with radiotherapy treatment alone. Radiother Oncol 59: 5-11
53. Puc HS, Heelan R, Mazumdar M, Herr H, Scheinfeld J, Vlamis V, Bajorin DF, Bosl GJ, Mencel P, Motzer RJ (1996) Management of residual mass in advanced seminoma: results and recommendations from the Memorial Sloan-Kettering Cancer Center. J Clin Oncol 14: 454-460
54. Raghavan D (2006) Increased late toxicity in 12-20 year survivors of germ cell tumours. 2006 Proceedings of ASCO Abstract No.4509
55. Read G, Stenning SP, Cullen MH, Parkinson MC, Horwich A, Kaye SB, Cook PA (1992) Medical Research Council prospective study of surveillance for stage I testicular teratoma. Medical Research Council Testicular Tumors Working Party. J Clin Oncol 10: 1762-1768
56. Richie JP, Garnick MB, Finberg H (1982) Computerized tomography: how accurate for abdominal staging of testis tumors? J Urol 127: 715-717
57. Ronckers CM, Erdmann CA, Land CE (2005) Radiation and breast cancer: a review of current evidence. Breast Cancer Res 7: 21-32
58. Ronnen EA, Kondagunta GV, Bacik J, Marion S, Bajorin DF, Sheinfeld J, Bosl GJ, Motzer RJ (2005) Incidence of late-relapse germ cell tumor and outcome to salvage chemotherapy. J Clin Oncol 23: 6999-7004
59. Rowland RG, Weisman D, Williams SD, Einhorn LH, Klatte EC, Donohue JP (1982) Accuracy of preoperative staging in stages A and B nonseminomatous germ cell testis tumors. J Urol 127: 718-720
60. Rustin GJS, Mead GM, Stenning SP et al (2007) A randomised trial of 2 versus 5 CT scans in the surveillance of patients with stage 1 nonseminomatous germ cell tumours of the testis: Medical Research Council Trial TE08, ISRCTN56475197. J Clin Oncol 25(11): 1310-1315
61. Schmidberger H, Bamberg M, Meisner C, Classen J, Winkler C, Hartmann M, Templin R, Wiegel T, Dornoff W, Ross D, Thiel HJ, Martini C, Haase W (1997) Radiotherapy in stage IIA and IIB testicular seminoma with reduced portals: a prospective multicenter study. Int J Radiat Oncol Biol Phys 39: 321-326
62. Schmoll HJ, Souchon R, Krege S, Albers P, Beyer J, Kollmannsberger C, Fossa SD, Skakkebaek NE, de Wit R, Fizazi K, Droz JP, Pizzocaro G, Daugaard G, de Mulder PH, Horwich A, Oliver T, Huddart R, Rosti G, Paz Ares L, Pont O, Hartmann JT, Aass N, Algaba F, Bamberg M, Bodrogi I, Bokemeyer C, Classen J, Clemm S, Culine S, de Wit M, Derigs HG, Dieckmann KP, Flasshove M, Garcia del Muro X, Gerl A, Germa-Lluch JR, Hartmann M, Heidenreich A, Hoeltl W, Joffe J, Jones W, Kaiser G, Klepp O, Kliesch S, Kisbenedek L, Koehrmann KU, Kuczyk M, Laguna MP, Leiva O, Loy V, Mason MD, Mead GM, Mueller RP, Nicolai N, Oosterhof GO, Pottek T, Rick O, Schmidberger H, Sedlmayer F, Siegert W, Studer U, Tjulandin S, von der Maase H, Walz P, Weinknecht S, Weissbach L, Winter E, Wittekind C (2004) European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG). Ann Oncol 15: 1377-1399
63. Shahidi M, Norman AR, Dearnaley DP, Nicholls J, Horwich A, Huddart RA (2002) Late recurrence in 1263 men with testicular germ cell tumors. Multivariate analysis of risk factors and implications for management. Cancer 95: 520-530
64. Sharir S, Jewett MA, Sturgeon JF, Moore M, Warde PR, Catton CN, Gospodarowicz MK (1999) Progression detection of stage I nonseminomatous testis cancer on surveillance: implications for the followup protocol. J Urol 161: 472-475; discussion 475-476
65. Sonneveld DJ, Hoekstra HJ, van der Graaf WT, Sluiter WJ, Mulder NH, Willemse PH, Koops HS, Sleijfer DT (2001) Improved long term survival of patients with metastatic nonseminomatous testicular germ cell carcinoma in relation to prognostic classification systems during the cisplatin era. Cancer 91: 1304-1315
66. Spermon JR, Roeleveld TA, van der Poel HG, Hulsbergen-van de Kaa CA, Ten Bokkel Huinink WW, van de Vijver M, Witjes JA, Horenblas S (2002) Comparison of surveillance and retroperitoneal lymph node dissection in Stage I nonseminomatous germ cell tumors. Urology 59: 923-929
67. Thomas JL, Bernardino ME, Bracken RB (1981) Staging of testicular carcinoma: comparison of CT and lymphangiography. AJR Am J Roentgenol 137: 991-996
68. Travis LB, Fossa SD, Schonfeld SJ, McMaster ML, Lynch CF, Storm H, Hall P, Holowaty E, Andersen A, Pukkala E, Andersson M, Kaijser M, Gospodarowicz M, Joensuu T, Cohen RJ, Boice Jr JD, Dores GM, Gilbert ES. (2005) Second Cancers among 40,576 Testicular Cancer Patients Focus on long term survivors. J Natl Cancer Inst 97(18): 1354-1365
69. Tuinman MA, Hoekstra HJ, Sleijfer DT, Fleer J, Vidrine DJ, Gritz ER, Hoekstra-Weebers JE (2007) Testicular cancer: a longitudinal pilot study on stress response symptoms and quality of life in couples before and after chemotherapy. Support Care Cancer 15: 279-286
70. van den Belt-Dusebout AW, Nuver J, de Wit R, Gietema JA, ten Bokkel Huinink WW, Rodrigus PT, Schimmel EC, Aleman BM, van Leeuwen FE (2006) Long-term risk of cardiovascular disease in 5-year survivors of testicular cancer. J Clin Oncol 24: 467-475
71. Vaughn DJ, Gignac GA, Meadows AT (2002) Long-term medical care of testicular cancer survivors. Ann Intern Med 136: 463-470
72. Venkitaraman R, Johnson B, Huddart RA, Parker CC, Horwich A, Dearnaley DP (2007) The utility of lactate dehydrogenase in the follow-up of testicular germ cell tumours. BJU Int 100: 30-32
73. Vergouwe Y, Steyerberg EW, Eijkemans MJ, Albers P, Habbema JD (2003) Predictors of occult metastasis in clinical stage I nonseminoma: a systematic review. J Clin Oncol 21: 4092-4099
74. Warde P, Gospodarowicz M, Panzarella T, Catton C, Sturgeon J, Moore M, Jewett M (1998) Management of stage II seminoma. J Clin Oncol 16: 290-294
75. Warde P, Specht L, Horwich A, Oliver T, Panzarella T, Gospodarowicz M, von der Maase H (2002) Prognostic factors for relapse in stage I seminoma managed by surveillance: a pooled analysis. J Clin Oncol 20: 4448-4452
76. White PM, Howard GC, Best JJ, Wright AR (1997) The role of computed tomographic examination of the pelvis in the management of testicular germ cell tumours. Clin Radiol 52: 124-129