Bayesian sample size for exploratory clinical trials incorporating historical data

Statistics in Medicine

Volumn 27, Issue 13, 2008, Pages 2307-2327

  Whitehead, John ^a   Valdés Márquez, Elsa ^b   Johnson, Patrick ^c   Graham, Gordon ^c  

^a LANCASTER UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Bayesian methods; Clinical trial; Phase II trial; Proof of concept study; Sample size; Score statistic

Indexed keywords

ANTINEOPLASTIC AGENT; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; SILDENAFIL;

ARTICLE; BAYES THEOREM; CLINICAL RESEARCH; CLINICAL TRIAL; COMPARATIVE STUDY; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESPONSE; HUMAN; LOWER URINARY TRACT SYMPTOM; MATHEMATICAL COMPUTING; METHODOLOGY; NEOPLASM; PHASE 2 CLINICAL TRIAL; PROBABILITY; SAMPLE SIZE; STATISTICAL ANALYSIS; STATISTICAL MODEL; TREATMENT RESPONSE;

BAYES THEOREM; CLINICAL TRIALS AS TOPIC; HUMANS; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; SAMPLE SIZE; URINARY TRACT INFECTIONS;

EID: 44949170805     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.3140     Document Type: Article

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