Differential use of Erk1/2 and transforming growth factor β pathways by mid- and late-gestational murine fibroblasts

Journal of Pediatric Surgery

Volumn 43, Issue 6, 2008, Pages 971-976

  Goldberg, Stephanie R ^a   Quirk, Gerald L ^a   Sykes, Virginia W ^a   McKinstry, Robert P ^a   Kordula, Tomasz ^a   Lanning, David A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fetal model; Fibroblast; Scar; Scratch assay; Transforming growth factor ; Wound healing

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; EXCISION; FETUS; FIBROBLAST CULTURE; GESTATIONAL AGE; HISTOPATHOLOGY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCAR FORMATION; SIGNAL TRANSDUCTION; SKIN INJURY; WOUND HEALING;

ANALYSIS OF VARIANCE; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLAST GROWTH FACTORS; FIBROBLASTS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PREGNANCY; PROBABILITY; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; WOUND HEALING; WOUNDS AND INJURIES;

EID: 44949113379     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2008.02.020     Document Type: Article

References (8)

1. Goldberg S.R., McKinstry R.P., Sykes V., et al. Rapid closure of mid-gestational excisional wounds in a fetal mouse model is associated with altered transforming growth factor-beta isoform and receptor expression. J Pediatr Surg 42 6 (2007) 966-971 [discussion 971-973]
2. Sousa A.M., Liu T., Guevara O., et al. Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2. J Cell Biochem 100 6 (2007) 1581-1592
3. Fitsialos G., Chassot A.A., Turchi L., et al. Transcriptional signature of epidermal keratinocytes subjected to in vitro scratch wounding reveals selective roles for ERK1/2, p38, and phosphatidylinositol 3-kinase signaling pathways. J Biol Chem 282 20 (2007) 15090-15102
4. Sharma G.D., He J., and Bazan H.E. p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades. J Biol Chem 278 24 (2003) 21989-21997
5. Zhang H.Y., Gharaee-Kermani M., Zhang K., et al. Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am J Pathol 148 2 (1996) 527-537
6. Colwell A.S., Faudoa R., Krummel T.M., et al. Transforming growth factor-beta, Smad, and collagen expression patterns in fetal and adult keratinocytes. Plast Reconstr Surg 119 3 (2007) 852-857
7. Matsubayashi Y., Ebisuya M., Honjoh S., et al. ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing. Curr Biol 14 8 (2004) 731-735
8. Rousseau S., Dolado I., Beardmore V., et al. CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal 18 11 (2006) 1897-1905