Respiratory and cardiovascular effects of buprenorphine in conscious rabbits

Veterinary Anaesthesia and Analgesia

Volumn 35, Issue 4, 2008, Pages 326-332

  Shafford, Heidi L ^a   Schadt, James C ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

Buprenorphine; Cardiovascular effects; Rabbit; Respiratory effects

Indexed keywords

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 44949104270     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.2007.00383.x     Document Type: Article

References (24)

1. Cowan A, Doxey JC, Harry E Jr. (1977) The animal pharmacology of buprenorphine, an oripavine analgesic agent. Br J Pharmacol 60, 547 554.
2. Dahan A, Yassen A, Romberg R et al. (2006) Buprenorphine induces ceiling in respiratory depression but not in analgesia. Br J Anaesth 96, 627 632.
3. Delpierre S, Vanuxem P (1992) Effects of buprenorphine on respiratory and cardiovascular functions during hypoxia in anaesthetized rabbits. Arch Int Pharmacodyn Ther 319, 49 57.
4. Dobromylskyj P, Flecknell PA, Lascelles BDX et al. (2006) Management of postoperative and other acute pain. In : Pain Management in Animals. Flecknell PA, Waterman-Pearson A (eds). WB Saunders, London, UK. pp. 81 145.
5. Doxey JC, Everitt JE, Frank LW et al. (1982) A comparison of the effects of buprenorphine and morphine on the blood gases of conscious rats. Br J Pharmacol 75, 118 (Abstract).
6. Drury DR, McMaster PD (1929) The relation of the liver to fat metabolism: I. Effect of liver lack on fat combustion and the respiratory quotient. J Exp Med 49, 765 778.
7. Flecknell PA, Liles JH (1990) Assessment of the analgesic action of opioid agonist-antagonists in the rabbit. J Assoc Vet Anaesth 17, 24 29.
8. Flecknell PA, John M, Mitchell M et al. (1983) Neuroleptanalgesia in the rabbit. Lab Anim 17, 104 109.
9. Flecknell PA, Liles JH, Wootton R (1989) Reversal of fentanyl/fluanisone neuroleptanalgesia in the rabbit using mixed agonist/antagonist opioids. Lab Anim 23, 147 155.
10. Gronan RJ, Schadt JC, York DH (1983) Routine, direct measurement of aortic pressure in the conscious rabbit. Physiol Behav 30, 719 722.
11. Institute of Laboratory Animal Resources, Commission on Life Sciences, & National Research Council (1996) Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC, USA.
12. Jacobson JD, McGrath CJ, Smith EP (1994) Cardiorespiratory effects of four opioid-tranquilizer combinations in dogs. Vet Surg 23, 299 306.
13. Ohtani M, Kotaki H, Nishitateno K et al. (1997) Kinetics of respiratory depression in rats induced by buprenorphine and its metabolite, norbuprenorphine. J Vet Pharmacol Ther 281, 428 233.
14. Roughan JV, Flecknell PA (2002) Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating post-operative pain in animals. Lab Anim 36, 322 343.
15. Sanford TD, Colby ED (1980) Effect of xylazine and ketamine on blood pressure, heart rate and respiratory rate in rabbits. Lab Anim Sci 30, 519 523.
16. Shafford HL, Schadt JC (2008) Effect of buprenorphine on the cardiovascular and respiratory response to visceral pain in conscious rabbits. Vet Anaesth Analg (in press).
17. Shafford HL, Strittmatter RR, Schadt JC (2006a) A novel electrode design for chronic recording of electromyographic activity. J Neurosci Methods 156, 228 230.
18. Shafford HL, Ivey JR, McKown MD et al. (2006b) Noxious visceral stimulation and the response to blood loss in conscious rabbits. FASEB J 20, A1383 A1384 (Abstract).
19. Shapiro BA, Peruzzi WT, Templin R (1994a) Arterial oxygenation. In : Clinical Application of Blood Gases (5th edn). Mosby, Inc, St Louis, MO, USA. pp. 33 53.
20. Shapiro BA, Peruzzi WT, Templin R (1994b) Normal ranges and interpretive guidelines. In : Clinical Application of Blood Gases (5th edn). Mosby, Inc, St Louis, MO, USA. pp. 57 67.
21. Szöke MO, Blaise D, Cuvelliez SG et al. (1998) Effects of buprenorphine on cardiovascular and pulmonary function in clinically normal horses and horses with chronic obstructive pulmonary disease. Am J Vet Res 59, 1287 1291.
22. Waterman AE, Livingston A, Amin A (1991) Further studies on the antinociceptive activity and respiratory effects of buprenorphine in sheep. J Vet Pharmacol Ther 14, 230 234.
23. West JB (2000) Tests of pulmonary function. In : Respiratory Physiology - The Essentials (6th edn). Lippincott, Williams & Wilkins, Philadelphia, PA, USA. pp. 131 142.
24. Wootton R, Cross G, West CD (1988) An analgesiometry system for use in rabbits with some preliminary data on the effects of buprenorphine and lofentanil. Lab Anim 22, 217 222.