PKC promotes proliferation of airway smooth muscle cells by regulating cyclinD1 expression in asthmatic rats

Acta Pharmacologica Sinica

Volumn 29, Issue 6, 2008, Pages 677-686

  Qiao, Li Fen ^a   Xu, Yong Jian ^a   Liu, Xian Sheng ^a   Xie, Jun Gang ^a   Wang, Jin ^a   Du, Chun Ling ^a   Zhang, Jian ^a   Ni, Wang ^a   Chen, Shi Xin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Asthma; Cell proliferation; CyclinD1; Muscle; Protein kinase C; Smooth

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CYCLIN D1; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL ASSAY; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; GENETIC TRANSCRIPTION; GROWTH REGULATION; LINEAR REGRESSION ANALYSIS; MALE; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; SMOOTH MUSCLE FIBER; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; ASTHMA; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; DNA FINGERPRINTING; GENE EXPRESSION REGULATION; MALE; MYOCYTES, SMOOTH MUSCLE; PLASMIDS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN KINASE C; RATS; RATS, INBRED BN;

EID: 44849136773     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00795.x     Document Type: Article

References (33)

1. Mcvicker CG, Leung SY, Kanabar V, Mori LM, Mahn K, Chung KF, et al. Repeated allegen inhalation induces cytoskeletal remodeling in smooth muscle from rat bronchioles. Am J Respir Cell Mol Biol 2007 36:721 7.
2. Palmans E, Kips JC, Pauwels RA. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am J Crit Care Med 2000 161:627 35.
3. Fixman ED, Stewart A, Martin JG. Basic mechanisms of development of airway structural changes in asthma. Eur Respir J 2007 29:379 89.
4. Janssen LJ, Killian K. Airway smooth muscle as a target of asthma therapy: history and new directions. Respir Res 2006 7:123.
5. Panettieri RA Jr. Airway smooth muscle: immunomodulatory cells that modulate airway remodeling? Respir Physiol Neurobiol 2003 137:277 93.
6. Jeffery PK. Remodeling in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001 164:S28 38.
7. Thompson LJ, Fields AP. Beta II protein kinase C is required for the G2/M phase transition of cell cycle. J Biol Chem 1996 271:15045 53.
8. Hofmann J. The potential for isoenzyme-selective modulation of protein kinase. FASEB J 1997 11:649 69.
9. Xu SY, Xu YJ, Zhang ZX, Ni W, Chen SX. Contribution of protein kinase C to passively sensitized human airway smooth muscle cells proliferation. Chin Med J 2004 117:30 6.
10. Duliæ V, Drullinger LF, Lees E, Reed SI, Stein GH. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inative cyclinE-Cdk2 and cyclinD1-Cdk2 Complexes. Proc Natl Acad Sci USA 1993 90:11 034 8.
11. Tagliati F, Zatelli MC, Bottoni A, Piccin D, Luchin A, Culler MD, et al. Role of complex cyclinD1/Cdk4 in somatostatin subtype 2 receptor-mediated inhibition of cell proliferation of a medullary thyroid carcinoma cell line in vitro. Endocrinology 2006 147:3535 8.
12. Surjit M, Liu B, Chow VT, Lal SK. The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells. J Biol Chem 2006 281:10 669 81.
13. Roy PG, Thompson AM. Cyclin D1 and breast cancer. Breast 2006 15:718 27.
14. Umekita Y, Ohi Y, Sagara Y, Yoshida H. Overexpression of cyclinD1 predicts for poor prognosis in estrogen receptor-negative breast cancer patients. Int J Cancer 2002 98:415 8.
15. Chunder N, Mandal S, Roy A, Roychoudhury S, Panda CK. Analysis of different deleted regions in chromosome 11 and their interrelations in early- and late-onset breast tumors: association with cyclin D1 amplification and survival. Mol Pathol 2004 13:172 82.
16. Salmon M, Walsh DA, Koto H, Barnes PJ, Chung KF. Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling. Eur Respir J 1999 14:633 41.
17. Hirst SJ. Airway smooth muscle cell culture: application to studies of airway wall remodelling and phenotype plasticity in asthma. Eur Respir J 1996 9:808 20.
18. Yan KX, Liu BC, Shi XL, You BR, Xu M. Role of cyclinD1 and CDK4 in the carcinogenesis induced by silica. Biomed Environ Sci 2005 18:286 96.
19. John M, Au BT, Jose PJ, Lim S, Saunders M, Barnes PJ, et al. Expression and release of interleukin-8 by human airway smooth muscle cells: inhibition by Th-2 cytokines and corticosteroids. Am J Respir Cell Mol Biol 1998 18:84 90.
20. Belvisi MG, Saunders M, Yacoub M, Mitchell JA. Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth. Br J Pharmacol 1998 125:1102 8.
21. Ingram JL, Rice AB, Geisenhoffer K, Madtes DK, Bonner JC. IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha. FASEB J 2004 18:1132 4.
22. Terada M, Kelly EA, Jarjour NN. Increased thrombin activity after allergen challenge: a potential link to airway remodeling? Am J Respir Crit Care Med 2004 169:373 7.
23. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, et al. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 2000 279:L429 38.
24. Liu WS, Heckman CA. The sevenfold way of PKC regulation. Cell Signal 1998 10:529 42.
25. Kuemmerle JF, Zhou H, Bowers JG. IGF-I stimulates human intestinal smooth muscle cell growth by regulation of G1 phase cell cycle proteins. Am J Physiol Gastrointest Liver Physiol 2004 286:G412 9.
26. Jaschke B, Milz S, Vogeser M, Michaelis C, Vorpahl M, Schomig A, et al. Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury. FASEB J 2004 18:1285 7.
27. Grassi G, Schneider A, Engel S, Racchi G, Kandolf R, Kuhn A. Hammerhead ribozymes targeted against cyclin E and E2F1 cooperate to down-regulate coronary smooth muscle cell proliferation. J Gene Med 2005 7:1223 34.
28. Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics 1992 13:565 374.
29. Möröy T, Geisen C. Cyclin E. Int J Biochem Cell Biol 2004 36:1424 339.
30. Liou SF, Yeh JL, Liang JC, Chiu CC, Lin YT, Chen IJ. Inhibition of mitogen-mediated proliferation of rat vascular smooth muscle cells by labedipinedilol-A through PKC and ERK 1/2 pathway. J Cardiovasc Pharmacol 2004 44:539 51.
31. Skaletz-Rorowski A, Eschert H, Leng J, Stallmeyer B, Sindermann JR, Pulawski E, et al. PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. Cardiovasc Res 2005 67:142 50.
32. Wu TT, Hsieh YH, Hsieh YS, Liu JY. Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. J Cell Biochem 2008 103:9 20.
33. Dempsey EC, Cool CD, Littler CM. Lung disease and PKCs. Pharmacol Res 2007 55:545 59.