Restricted expression of Epstein-Barr virus latent genes in murine B cells derived from embryonic stem cells

PLoS ONE

Volumn 3, Issue 4, 2008, Pages

  Zychlinska, Magdalena ^a   Herrmann, Heidrun ^a   Zimber Strobl, Ursula ^b   Hammerschmidt, Wolfgang ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN; LATENT MEMBRANE PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; EMBRYONIC STEM CELL; EPSTEIN BARR VIRUS; GENE CONTROL; GENE EXPRESSION; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE TRANSFORMATION; MOUSE; NONHUMAN; RNA PROCESSING; RNA SPLICING; VIRUS GENE; VIRUS GENOME; VIRUS LATENCY; VIRUS PATHOGENESIS; VIRUS RECOMBINANT; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINE; CELL SEPARATION; CELL TRANSFORMATION; CHEMISTRY; CYTOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; METABOLISM; VIROLOGY;

HUMAN HERPESVIRUS 4; MURINAE; PRIMATES; RODENTIA;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; CELL SEPARATION; CELL TRANSFORMATION, NEOPLASTIC; EMBRYONIC STEM CELLS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 4, HUMAN; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; RNA, MESSENGER;

EID: 44849122656     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001996     Document Type: Article

References (37)

1. Anonymous (1997) Epstein-Barr virus and Kaposi's sarcoma herpesvirus/ human herpesvirus 8; International Agency for Research on Cancer. Lyon: IARC.
2. Kieff E, Rickinson AB (2007) Epstein-Barr virus and its replication. In: Knipe DM, Howley PM, Griffin DE, Martin MA, Lamb RA, Roizman B, Straus SE, eds (2007) Fields Virology. Philadelphia: Lippincott-Williams & Wilkins. pp 2603-2654.
3. Young LS, Rickinson AB (2004) Epstein-Barr virus: 40 years on. Nat Rev Cancer 4: 757-768.
4. Shultz LD, Ishikawa F, Greiner DL (2007) Humanized mice in translational biomedical research. Nat Rev Immunol 7: 118-130.
5. Olivadoti M, Toth LA, Weinberg J, Opp MR (2007) Murine gammaherpesvirus 68: a model for the study of Epstein-Barr virus infections and related diseases. Comp Med 57: 44-50.
6. Bornkamm GW, Hammerschmidt W (2001) Molecular virology of Epstein-Barr virus. Philos Trans R Soc Lond B Biol Sci 356: 437-459.
7. Thomae AW, Pich D, Brocher J, Spindler MP, Berens C, et al. (2008) Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins. Proc Natl Acad Sci U S A 105: 1692-1697.
8. Altmann M, Pich D, Ruiss, R, Wang J, Sugden B, et al (2006) Transcriptional activation by EBV nuclear antigen 1 is ossential for the expression of EBV's transforming genes. Proc Natl Acad Sci U S A 103: 14188-14193.
9. Mancao C, Hammerschmidt W (2007) Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival. Blood 110: 3715-3721.
10. Schneider F, Neugebauer J, Griese J, Liefold N, Kutz H, et al. (2008) The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity. PLoS Biol 6: e8.
11. Nemerow GR, Houghten RA, Moore MD, Cooper NR (1989) Identification of an epitope in the major envelope protein of Epstein-Barr vinis that mediates viral binding to the B lymphocyte EBV receptor (CR2). Cell 56: 369-377.
12. Li Q, Spriggs MK, Kovats S, Turk SM, Comeau MR, et al. (1997) Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes. J Virol 71: 4657-4662.
13. Haan KM, Aiyar A, Longnecker R (2001) Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in murine B-cell lines. J Virol 75: 3016-3020.
14. Marchbank KJ, Watson CC, Ritsema DF, Holers VM (2000) Expression of human complement receptor 2 (CR2, CD21) in Cr2-/- mice restores humoral immune function. J Immunol 165: 2354-2361.
15. Zambrowicz BP, Imamoto A, Fiering S, Herzenberg LA, Kerr WG, et al. (1997) Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoictic cells. Proc Natl Acad Sci U S A 94: 3789-3794.
16. Delecluse HJ, Hilsendegen T, Pich D, Zeidlcr R, Hammerschmidt W (1998) Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells. Proc Natl Acad Sci U S A 95: 8245-8250.
17. Kempkes B, Pich D, Zeidler R, Hammerschmidt W (1995) Immortalization of human primary B lymphocytes in vitro with DNA. Proc Natl Acad Sci U S A 92: 5875-5879.
18. Kempkes B, Pich D, Zeidler R, Sugden B, Hammerschmidt W (1995) Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA. J Virol 69: 231-238.
19. Boiani M, Scholer HR (2005) Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 6: 872-884.
20. Nakano T, Kodama H, Honjo T (1994) Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 265: 1098-1101.
21. Cho SK, Webber TD, Carlyle JR, Nakano T, Lewis SM, et al. (1999) Functional characterization of B lymphocytes generated in vitro from embryonic stem cells. Proc Natl Acad Sci U S A 96: 9797-9802.
22. Katamine S, Otsu M, Tada K, Tsuchiya S, Sato T, et al. (1984) Epstein-Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements. Nature 309: 369-372.
23. Hansson M, Falk K, Ernberg I (1983) Epstein-Barr virus transformation of human pre-B cells. J Exp Med 158: 616-622.
24. Gregory CD, Kirchgens C, Edwards CF, Young LS, Rowe M, et al. (1987) Epstein-Barr virus-transformed human precursor B cell lines: altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain genes. Eur J Immunol 17: 1199-1207.
25. Rickinson AB, Kieff E (2007) Epstein-Barr virus. In: Knipe DM, Howley PM, Griffin DE, Martin MA, Lamb RA, Roizman B, Straus SE, eds (2007) Fields Virology. Philadelphia: Lippincott-Williams & Wilkins. pp 2655-2700.
26. Maeda A, Bandobashi K, Nagy N, Teramoto N, Gogolak P, et al. (2001) Epstein-Barr virus can infect B-chronic lymphocytic leukemia cells but it does not orchestrate the cell cycle regulatory proteins. J Hum Virol 4: 227-237.
27. Krysan PJ, Calos MP (1993) Epstein-Bare viros-based vectors that replicate in rodent cells. Gene 136: 137-143.
28. Hammerschmidt W, Sugden B (2006) Epstein-Barr Virus. In: DePamphilis ML, ed (2006) DNA replication and Human Disease. New York. Cold Spring Harbor Laboratory Press. pp 687-705.
29. Humme S, Reisbach G, Feederle R, Delecluse HJ, Bousset K, et al. (2003) The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold. Prov Natl Acad Sci U S A 100: 10989-10994.
30. Mansilla A, Lopez-Sanchez C, de la Rosa EJ, Garcia-Martinez V, Martinez-Salas E, et al. (2005) Developmental regulation of a proinsulin messenger RNA generated by intron retention. EMBO Rep 6: 1182-1187.
31. Son GH, Jung H, Seong JY, Cline Y, Geum D, et al. (2003) Excision of the first intron from the gonadotropin-releasing hormone (GnRH) transcript serves as a key regulatory step for GnRH biosynthesis. J Biol Chem 278: 18037-18044.
32. Lemischka JR, Pritsker M (2006) Alternative splicing increases complexity of stem cell transcriptome. Cell Cycle 5: 347-351.
33. Minarovits J (2006) Epigenotypes of latent herpesvirus genomes. Curr Top Microbiol Immunol 310: 61-80.
34. Surani MA, Hayashi K, Hajkova P (2007) Genetic and epigenetic regulators of pluripotency. Cell 128: 747-762.
35. Ren C, Zhao M, Yang X, Li D, Jiang X, et al. (2006) Establishment and applications of Epstein-Barr virus-based episomal vectors in human embryonic stem cells. Stem Cells 24: 1338-1347.
36. Miller G, Shope T, Lisco H, Stitt D, Lipman M (1972) Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes. Proc Natl Acad Sci U S A 69: 383-387.
37. Pulvertaft JV (1964) Cytology Of Burkitt's Tumour (African Lymphoma). Lancet 39: 238-240.