Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay

Skin Pharmacology and Physiology

Volumn 21, Issue 3, 2008, Pages 181-187

  Borelli, C ^a,d   Gassmueller, J ^b   Fluhr, J W ^b   Nietsch, K H ^c   Schinzel, S ^c   Korting, H C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Bioskin GmbH   (Germany)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Bioavailability; Chromametric measurement; Corticosteroids; Desoximetasone

Indexed keywords

BETAMETHASONE; BETAMETHASONE DIPROPIONATE; CLOBETASOL PROPIONATE; DESOXIMETASONE; DRUG VEHICLE; GLUCOCORTICOID; HYDROCORTISONE; KARISON; SANATISON; TOPISOLON;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OINTMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; VASOCONSTRICTION;

ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; AGED; ANTI-INFLAMMATORY AGENTS; BETAMETHASONE; BIOLOGICAL AVAILABILITY; CLOBETASOL; DESOXIMETASONE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; SKIN; SKIN ABSORPTION; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VEHICLES;

EID: 44849108613     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000131082     Document Type: Conference Paper

References (14)

1. Luger T, Loske KD, Elsner P, Kapp A, Kerscher M, Korting HC, Krutmann J, Niedner R, Röcken M, Ruzicka T, Schwarz T: Topical skin therapy with glucocorticoids - Therapeutic index. J Dtsch Dermatol Ges 2004;2:629-634.
2. Niedner R: Entwicklung der topischen Kortikoide; in Niedner R (ed): Kortikoide in der Dermatologie. Bremen, Uni-med, 1998.
3. McKenzie A, Stoughton R: Method for comparing percutaneous absorption of corticosteroids. Arch Dermatol 1962;86:608-610.
4. Seidenari S, Di Nardo A, Mantovani L, Giannetti A: Parallel intraindividual evaluation of the vasoconstrictory action and the anti-allergic activity of topical corticosteroids. Exp Dermatol 1997;6:75-80.
5. Woodford R, Barry BW: Proceedings: comparative bioavailability of proprietary hydrophilic topical steroid preparations. J Pharm Pharmacol 1973;25(suppl):123.
6. Gorne RC, Greif C, Metzner U, Wigger-Alberti W, Elsner P: Assessment of topical corticosteroid activity using the vasoconstriction assay in healthy volunteers. Skin Pharmacol Physiol 2007;20:133-140.
7. Savin RC: Desoximetasone - A new topical corticosteroid: short- and long-term experiences. Cutis 1978;21:403-407.
8. Hebert AA, Koo J, Fowler J, Berman B, Rosenberg C, Levitt J: Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis. Cutis 2006;78:357-363.
9. Henry M, Hanks G, Whelan A: A randomized, double-blind therapeutic trial of 0.25% desoxymethasone and 0.1% hydrocortisone 17-butyrate in the treatment of varicose eczema. Curr Med Res Opin 1980;6:502-506.
10. Ashton RE, Catterall M, Morley N, Fairris G, Joseph DN: A double-blind comparison of 0.25% and 0.05% desoxymethasone, 0.1% betamethasone valerate and 1% hydrocortisone creams in the treatment of eczema. J Int Med Res 1987;15:160-166.
11. Queille-Roussel C, Poncet M, Schaefer H: Quantification of skin-colour changes induced by topical corticosteroid preparations using the Minolta Chroma Meter. Br J Dermatol 1991;124:264-270.
12. Morgan JF: p Value fetishism and use of the Bonferroni adjustment. Evid Based Ment Health 2007;10:34-35.
13. Krochmal L, Wang JC, Patel B, Rodgers J: Topical corticosteroid compounding: effects on physicochemical stability and skin penetration rate. J Am Acad Dermatol 1989;21:979-984.
14. Korting HC, Maslen K, Gross G, Willers C: Comparison of activity of different topical corticosteroid creams and ointments using a vasoconstriction assay: superiority of hydrocortisone butyrate over hydrocortisone. J Dtsch Dermatol Ges 2005;3:348-353.