Processing of the circumsporozoite protein in infected hepatocytes is not dependent on aspartic proteases

Parasite Immunology

Volumn 30, Issue 6-7, 2008, Pages 375-378

  Bongfen, S E ^a   Balam, S ^a   Torgler, R ^a   Romero, J F ^a   Corradin, G ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Antigen processing presentation; Circumsporozoite protein; Infected hepatocytes; Plasmodium berghei

Indexed keywords

ASPARTIC PROTEINASE; CIRCUMSPOROZOITE PROTEIN; PROTEASOME;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; IMMUNE RESPONSE; LIVER CELL; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PRIORITY JOURNAL; PROTEIN PROCESSING; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, PROTOZOAN; ASPARTIC ENDOPEPTIDASES; CD8-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; HEPATOCYTES; MALARIA; MICE; MICE, INBRED BALB C; PLASMODIUM BERGHEI; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTOZOAN PROTEINS; SPOROZOITES;

PLASMODIUM BERGHEI;

EID: 44849102524     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2008.01032.x     Document Type: Article

References (18)

1. Good MF Doolan DL. Immune effector mechanisms in malaria. Curr Opin Immunol 1999 11 : 412 419.
2. + T lymphocytes is required for protective immunity against Plasmodium berghei. J Immunol 1996 156 : 3374 3381.
3. Romero P, Maryanski JL, Corradin G, Nussenzweig RS, Nussenzweig V Zavala F. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature 1989 341 : 323 326.
4. Mota MM, Pradel G, Vanderberg JP, et al. Migration of Plasmodium sporozoites through cells before infection. Science 2001 291 : 141 144.
5. + T cells in vitro. J Immunol 2007 178 : 7054 7063.
6. Ishino T, Yano K, Chinzei Y Yuda M. Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer. Plos Biol 2004 2 : E4.
7. Scheller LF Azad AF. Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites. Proc Natl Acad Sci USA 1995 92 : 4066 4068.
8. Mueller AK, Deckert M, Heiss K, Goetz K, Matuschewski K Schluter D. Genetically attenuated Plasmodium berghei liver stages persist and elicit sterile protection primarily via CD8 T cells. Am J Pathol 2007 171 : 107 115.
9. Munz C. Autophagy and antigen presentation. Cell Microbiol 2006 8 : 891 898.
10. Lawrence BP Brown WJ. Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes. J Cell Sci 1992 102 : 515 526.
11. Prato S, Maxwell T, Pinzon-Charry A, Schmidt CW, Corradin G Lopez JA. MHC class I-restricted exogenous presentation of a synthetic 102-mer malaria vaccine polypeptide. Eur J Immunol 2005 35 : 681 689.
12. Savina A, Jancic C, Hugues S, et al. NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell 2006 126 : 205 218.
13. Jancic C, Savina A, Wasmeier C, et al. Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes. Nat Cell Biol 2007 9 : 367 378.
14. Hugel FU, Pradel G Frevert U. Release of malaria circumsporozoite protein into the host cell cytoplasm and interaction with ribosomes. Mol Biochem Parasitol 1996 81 : 151 170.
15. Singh AP, Buscaglia CA, Wang Q, et al. Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell 2007 131 : 492 504.
16. van de Sand C, Horstmann S, Schmidt A, et al. The liver stage of Plasmodium berghei inhibits host cell apoptosis. Mol Microbiol 2005 58 : 731 742.
17. Liang CEX Jung JU. Downregulation of autophagy by herpesvirus Bcl-2 homologs. Autophagy 2007 4.
18. + T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat Med 2007 13 : 1035 1041.