Brain response to visual sexual stimuli in heterosexual and homosexual males

Human Brain Mapping

Volumn 29, Issue 6, 2008, Pages 726-735

  Paul, Thomas ^a   Schiffer, Boris ^b   Zwarg, Thomas ^b   Krüger, Tillmann H C ^c   Karama, Sherif ^d   Schedlowski, Manfred ^c   Forsting, Michael ^a   Gizewski, Elke R ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c ETH ZURICH   (Switzerland)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Functional magnetic resonance imaging; Sexual arousal; Sexual orientation

Indexed keywords

ADULT; ARTICLE; AUDIOVISUAL EQUIPMENT; DATA ANALYSIS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HETEROSEXUAL MALE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; MALE; MALE HOMOSEXUAL; NORMAL HUMAN; PRIORITY JOURNAL; SEXUAL AROUSAL; SEXUAL ORIENTATION; VOLUNTEER;

ADULT; CEREBRAL CORTEX; EROTICA; HETEROSEXUALITY; HOMOSEXUALITY; HUMANS; HYPOTHALAMUS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PHOTIC STIMULATION; SEXUAL BEHAVIOR;

EID: 44849093996     PISSN: 10659471     EISSN: None     Source Type: Journal    
DOI: 10.1002/hbm.20435     Document Type: Article

References (38)

1. Allen LS, Gorski RA (1992): Sexual orientation and the size of the anterior commissure in the human brain. Proc Natl Acad Sci USA 89:7199-7202.
2. Arnow BA, Desmond JE, Banner LL, Glover GH, Solomon A, Polan ML, Lue TF, Atlas SW (2002): Brain activation and sexual arousal in healthy, heterosexual males. Brain 125 (Part 5):1014-1023.
3. Augustine JR (1996): Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Brain Res Rev 22:229-244.
4. Beauregard M, Levesque J, Bourgouin P (2001): Neural correlates of conscious self-regulation of emotion. J Neurosci 21:RC165.
5. 2O PET study in heterosexual men. Neuroimage 14 (1 Part 1):105-117.
6. Breiter HC, Etcoff NL, Whalen PJ, Kennedy WA, Rauch SL, Buckner RL, Strauss MM, Hyman SE, Rosen BR (1996): Response and habituation of the human amygdala during visual processing of facial expression. Neuron 17:875-887.
7. Byne W, Tobet S, Mattiace LA, Lasco MS, Kemether E, Edgar MA, Morgello S, Buchsbaum MS, Jones LB (2001): The interstitial nuclei of the human anterior hypothalamus: An investigation of variation with sex, sexual orientation, and HIV status. Horm Behav 40:86-92.
8. Critchley HD, Melmed RN, Featherstone E, Mathias CJ, Dolan RJ (2002): Volitional control of autonomic arousal: A functional magnetic resonance study. Neuroimage 16:909-919.
9. Devinsky O, Morrell MJ, Vogt BA (1995): Contributions of anterior cingulate cortex to behaviour. Brain 118 (Part 1):279-306.
10. Francis S, Rolls ET, Bowtell R, McGlone F, O'Doherty J, Browning A, Clare S, Smith E (1999): The representation of pleasant touch in the brain and its relationship with taste and olfactory areas. Neuroreport 10:453-459.
11. Friston KJ, Holmes AP, Poline JB, Grasby PJ, Williams SC, Frackowiak RS, Turner R (1995): Analysis of fMRI time-series revisited. Neuroimage 2:45-53.
12. Hagemann JH, Berding G, Bergh S, Sleep DJ, Knapp WH, Jonas U, Stief CG (2003): Effects of visual sexual stimuli and apomorphine SL on cerebral activity in men with erectile dysfunction. Eur Urol 43:412-420.
13. Hamann S, Herman RA, Nolan CL, Wallen K (2004): Men and women differ in amygdala response to visual sexual stimuli. Nat Neurosci 7:411-416.
14. Holstege G, Georgiadis JR, Paans AM, Meiners LC, van der Graaf FH, Reinders AA (2003): Brain activation during human male ejaculation. J Neurosci 23:9185-9193.
15. Karama S, Lecours AR, Leroux JM, Bourgouin P, Beaudoin G, Joubert S, Beauregard M (2002): Areas of brain activation in males and females during viewing of erotic film excerpts. Hum Brain Mapp 16:1-13.
16. Kinsey AC, Pomeroy WR, Martin C (1948): Sexual Behavior in the Human Male. Philadelphia: W.B. Saunders.
17. Kruger TH, Haake P, Haverkamp J, Kramer M, Exton MS, Saller B, Leygraf N, Hartmann U, Schedlowski M (2003): Effects of acute prolactin manipulation on sexual drive and function in males. J Endocrinol 179:357-365.
18. Kupfermann I (1991): Hypothalamus and the limbic system: Peptidergic neurons, homeostasis, and emotional behavior. In: Kandel ER, Schwartz GE, Jessell TM, editors. Principles of Neural Science. Norwalk: Appleton and Lange.
19. Lane RD, Reiman EM, Ahem GL, Schwartz GE, Davidson RJ (1997): Neuroanatomical correlates of happiness, sadness, and disgust. Am J Psychiatry 154:926-933.
20. Le Vay S (1996): Queer Science. The Use and Abuse of Research into Homosexuality. Oxford: MIT Press.
21. LeVay S (1991): A difference in hypothalamic structure between heterosexual and homosexual men. Science 253:1034-1037.
22. Mavissakalian M, Blanchard EB, Abel GC, Barlow DH (1975): Responses to complex erotic stimuli in homosexual and heterosexual males. Br J Psychiatry 126:252-257.
23. McConaghy N (1999): Unresolved issues in scientific sexology. Arch Sex Behav 28:285-318.
24. Montorsi F, Perani D, Anchisi D, Salonia A, Scifo P, Rigiroli P, Zanoni M, Heaton JP, Rigatti P, Fazio F (2003): Apomorphine-induced brain modulation during sexual stimulation: A new look at central phenomena related to erectile dysfunction. Int J Impot Res 15:203-209.
25. Morris JS, Ohman A, Dolan RJ (1998): Conscious and unconscious emotional learning in the human amygdala. Nature 393:467-470.
26. Mouras H, Stoleru S, Bittoun J, Glutron D, Pelegrini-Issac M, Paradis AL, Burnod Y (2003): Brain processing of visual sexual stimuli in healthy men: A functional magnetic resonance imaging study. Neuroimage 20:855-869.
27. Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC (1992): Cardiovascular effects of human insular cortex stimulation. Neurology 42:1727-1732.
28. Park K, Kang HK, Seo JJ, Kim HJ, Ryu SB, Jeong GW (2001a): Blood-oxygenation-level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response. Urology 57:1189-1194.
29. Park K, Seo JJ, Kang HK, Ryu SB, Kim HJ, Jeong GW (2001b): A new potential of blood oxygenation level dependent (BOLD) functional MRI for evaluating cerebral centers of penile erection. Int J Impot Res 13:73-81.
30. Phillips ML, Young AW, Senior C, Brammer M, Andrew C, Calder AJ, Bullmore ET, Perrett DI, Rowland D, Williams SC, Gray JA, David AS (1997): A specific neural substrate for perceiving facial expressions of disgust. Nature 389:495-498.
31. Rauch SL, Shin LM, Dougherty DD, Alpert NM, Orr SP, Lasko M, Macklin ML, Fischman AJ, Pitman RK (1999): Neural activation during sexual and competitive arousal in healthy men. Psychiatry Res 91:1-10.
32. Redoute J, Stoleru S, Gregoire MC, Costes N, Cinotti L, Lavenne F, Le Bars D, Forest MG, Pujol JF (2000): Brain processing of visual sexual stimuli in human males. Hum Brain Mapp 11:162-177.
33. Stoleru S, Gregoire MC, Gerard D, Decety J, Lafarge E, Cinotti L, Lavenne F, Le Bars D, Vernet-Maury E, Rada H, Collet C, Mazoyer B, Forest MG, Magnin F, Spira A, Comar D (1999): Neuroanatomical correlates of visually evoked sexual arousal in human males. Arch Sex Behav 28:1-21.
34. Stoleru S, Redoute J, Costes N, Lavenne F, Bars DL, Dechaud H, Forest MG, Pugeat M, Cinotti L, Pujol JF (2003): Brain processing of visual sexual stimuli in men with hypoactive sexual desire disorder. Psychiatry Res 124:67-86.
35. Talairach J, Tournoux P (1988): Co-planar Stereotactic Atlas of the Human Brain. New York: Thieme.
36. Tiihonen J, Kuikka J, Kupila J, Partanen K, Vainio P, Airaksinen J, Eronen M, Hallikainen T, Paanila J, Kinnunen I, Huttunen J (1994): Increase in cerebral blood flow of right prefrontal cortex in man during orgasm. Neurosci Lett 170:241-243.
37. Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G (2003): Both of us disgusted in My insula: The common neural basis of seeing and feeling disgust. Neuron 40:655-664.
38. Yang JC (2004): Functional neuroanatomy in depressed patients with sexual dysfunction: Blood oxygenation level dependent functional MR imaging. Korean J Radiol 5:87-95.