The antiproliferative effect of bovine lactoferrin on canine mammary gland tumor cells

Journal of Veterinary Medical Science

Volumn 70, Issue 5, 2008, Pages 443-448

  Yamada, Yuichi ^a,b   Sato, Reeko ^b   Kobayashi, Saori ^b   Hankanga, Careen ^b   Inanami, Osamu ^c   Kuwabara, Mikinori ^c   Momota, Yutaka ^b   Tomizawa, Nobuyuki ^b   Yasuda, Jun ^b  

^a GIFU UNIVERSITY   (Japan)

^b IWATE UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Bovine lactoferrin; Canine mammary gland tumor cell; G1 arrest

Indexed keywords

ANTINEOPLASTIC AGENT; LACTOFERRIN;

ADENOCARCINOMA; ANIMAL; ANIMAL DISEASE; ARTICLE; CATTLE; DOG; DOSE RESPONSE; EXPERIMENTAL NEOPLASM; TIME; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL LINE, TUMOR; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; LACTOFERRIN; MAMMARY NEOPLASMS, ANIMAL; TIME FACTORS;

ANIMALIA; BOVINAE; CANIS FAMILIARIS;

EID: 44849093353     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.70.443     Document Type: Article

References (14)

1. Chierici, R. 2001. Antimicrobial action of lactoferrin. Adv. Nutr. Res. 10: 247-268.
2. Damiens, E., E.l., Yazidi, I., Mazurier, J., Duthille, I., Spik, G. and Boilly-Marer, Y. 1999. Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells. J. Cell Biochem. 74: 486-498.
3. Hayashida, K., Takeuchi, T., Shimizu, H., Ando, K. and Harada, E. 2003. Novel function of bovine milk-derived lactoferrin on antinociception mediated by mu-opioid receptor in the rat spinal cord. Brain Res. 965: 239-245.
4. Hayes, T.G., Falchook, G.F., Varadhachary, G.R., Smith, D.P., Davais, L.D., Dhingra, H.M., Hayes, B.P. and Varadhachary, A. 2006. Phase I trial of oral talactoferrin alfa in refractory solid tumor. Invest New Drugs. 24: 233-240.
5. Hurley, W.L., Hegarty, H.M. and Metzler J.T. 1994. In vitro inhibition of mammary cell growth by lactoferrin; a comparative study. Life Sci. 55: 1955-1963.
6. Kuhara, T., Iigo, M., Itoh, T., Ushida, Y., Sekine, K., Terada, N., Okamura, H. and Tsuda, H. 2000. Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr. Cancer. 38: 192-199.
7. Masson, P.L., Heremans, J.F. and Schönne, E. 1969. Lactoferrin an iron binding protein neutrophilic leukocytes. J. Exp. Med. 130: 643-658.
8. Nakagawa, T., Watanabe, M., Ohashi., Uyama, R., Takauji, S., Mochizuki, M., Nishimura, R., Ogawa, H., Sugano, S. and Sasaki, N. 2006. Cyclopedic protein expression analysis of cultured canine mammary gland adenocarcinoma cells from six tumors. Res. Vet. Sci. 80: 317-323.
9. Shimamura, M., Yamamoto, Y., Ashino, H., Oikawa, T., Hazoto, T., Tsuda, H. and Iigo, M. 2004. Bovine lactoferrin inhibits tumor-inducing angiogenesis. Int. J. Cancer. 111: 111-116.
10. Seganti, L., Di Biase, A.M., Marchetti, M., Pietrantoni, A., Tinari, A. and Superti, F. 2004. Antiviral activity of lactoferrin towards naked virus. Biometals. 17: 295-299.
11. Son, H.J., Lee, S.H. and Choi, SY. 2006. Human lactoferrin controls the level of retinoblastoma protein and its activity. Biochem. Cell Biol. 84: 345-350.
12. Suzuki, A.Y., Kobayashi, K., Ishibashi, H., Mizuno, K., Yoshida, S., Wachi, H. and Seyama, Y. 2007. Bovine lactoferrin promotes wound healing in diabetic mice. 8th International Conference on Lactoferrin (Proceedings), :38
13. Wolf, J.S., Li, G., Varadhachary, A., Petrak, K., Schneyer, M., Li, D., Ongkasuwan, J., Zhang, X., Taylor, R.J., Strome, S.E. and O'Malley, B.W., Jr. 2007. Oral lactoferrin results in T cell -dependent tumor inhibition of Head and Neck squamous cell carcinoma in vivo. Clin. Cancer Res. 13: 1601-1610.
14. Xiao, Y., Monitto, C.L., Minhas, K.M. and Sidransky, D. 2004. Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of Head and Neck cancer cells. Clin. Cancer Res. 10: 8683-8686.