Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia

Parasite Immunology

Volumn 30, Issue 6-7, 2008, Pages 334-341

  Mibei, E K ^b   Otieno, W O ^c   Orago, A S S ^b   Stoute, J A ^a,d  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b KENYATTA UNIVERSITY   (Kenya)

^c KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^d Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

Anaemia; Cerebral malaria; Circulating immune complexes; Malaria

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY;

ANEMIA; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BLOOD SAMPLING; BRAIN MALARIA; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; KENYA; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRESCHOOL CHILD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCHOOL CHILD;

ANEMIA; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGEN-ANTIBODY COMPLEX; CHILD, PRESCHOOL; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INFANT; KENYA; LOGISTIC MODELS; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; RISK FACTORS;

PLASMODIUM FALCIPARUM;

EID: 44849090439     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2008.01030.x     Document Type: Article

References (41)

1. Jakobsen PH, Moon R, Ridley RG, et al. Tumour necrosis factor and interleukin-6 production induced by components associated with merozoite proteins of Plasmodium falciparum. Parasite Immunol 1993 15 : 229 237.
2. Jhaveri KN, Ghosh K, Mohanty D, et al. Autoantibodies, immunoglobulins, complement and circulating immune complexes in acute malaria. Natl Med J India 1997 10 : 5 7.
3. Tyagi P Biswas S. Naturally occurring plasmodia-specific circulating immune complexes in individuals of malaria endemic areas in India. Indian J Malariol 1999 36 : 12 18.
4. Gomez-Guerrero C, Lopez-Franco O, Suzuki Y, et al. Nitric oxide production in renal cells by immune complexes: Role of kinases and nuclear factor-κB. Kidney Int 2002 62 : 2022 2034.
5. Adam C, Geniteau M, Gougerot-Pocidalo M, et al. Cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria. Infect Immun 1981 31 : 530 535.
6. Mibei EK, Orago AS Stoute JA. Immune complex levels in children with severe Plasmodium falciparum malaria. Am J Trop Med Hyg 2005 72 : 593 599.
7. Foreback JL, Remick DG, Crockett-Torabi E Ward PA. Cytokine responses of human blood monocytes stimulated with Igs. Inflammation 1997 21 : 501 517.
8. Groux H Gysin J. Opsonization as an effector mechanism in human protection against asexual blood stages of Plasmodium falciparum: functional role of IgG subclasses. Res Immunol 1990 141 : 529 542.
9. Lucisano Valim YM Lachmann PJ. The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions. Clin Exp Immunol 1991 84 : 1 8.
10. Owuor BO, Odhiambo CO, Otieno WO, Adhiambo C, Makawiti DW Stoute JA. Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia. Mol Med 2008 14 : 89 97.
11. Hay SI, Noor AM, Simba M, et al. Clinical epidemiology of malaria in the highlands of western Kenya. Emerg Infect Dis 2002 8 : 543 548.
12. Molyneux ME, Taylor TE, Wirima JJ Borgstein A. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 1989 71 : 441 459.
13. Kokwaro G, Mwai L Nzila A. Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria. Expert Opin Pharmacother 2007 8 : 75 94.
14. Schauer U, Stemberg F, Rieger CH, et al. IgG subclass concentrations in certified reference material 470 and reference values for children and adults determined with the binding site reagents. Clin Chem 2003 49 : 1924 1929.
15. Jancar S Sanchez CM. Immune complex-mediated tissue injury: a multistep paradigm. Trends Immunol 2005 26 : 48 55.
16. Debets JM, van der Linden CJ, Dieteren IE, Leeuwenberg JF Buurman WA. Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes. J Immunol 1988 141 : 1197 1201.
17. Clark IA Cowden WB. Roles of TNF in malaria and other parasitic infections. Immunol Series 1992 56 : 365 407.
18. Maeno Y, Steketee RW, Nagatake T, et al. Immunoglobulin complex deposits in Plasmodium falciparum-infected placentas from Malawi and Papua New Guinea. Am J Trop Med Hyg 1993 49 : 574 580.
19. Maeno Y, Perlmann P, Perlmann H, et al. IgE deposition in brain microvessels and on parasitized erythrocytes from cerebral malaria patients. Am J Trop Med Hyg 2000 63 : 128 132.
20. Nyakeriga MA, Troye-Blomberg M, Bereczky S, Perlmann H, Perlmann P Elghazali G. Immunoglobulin E (IgE) containing complexes induce IL-4 production in human basophils: effect on Th1-Th2 balance in malaria. Acta Trop 2003 86 : 55 62.
21. Waitumbi JN, Opollo MO, Muga RO, et al. Red cell surface changes and erythrophagocytosis in children with severe Plasmodium falciparum anemia. Blood 2000 95 : 1481 1486.
22. Waitumbi JN, Donvito B, Kisserli A, Cohen JH Stoute JA. Age-related changes in red blood cell complement regulatory proteins and susceptibility to severe malaria. J Infect Dis 2004 190 : 1183 1191.
23. Davies KA, Hird V, Stewart S, et al. A study of in vivo immune complex formation and clearance in man. J Immunol 1990 144 : 4613 4620.
24. Calissano C, Modiano D, Sirima BS, et al. IgE antibodies to Plasmodium falciparum and severity of malaria in children of one ethnic group living in Burkina Faso. Am J Trop Med Hyg 2003 69 : 31 35.
25. Perlmann H, Helmby H, Hagstedt M, et al. IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. Clin Exp Immunol 1994 97 : 284 292.
26. Perlmann P, Perlmann H, Elghazali G Blomberg MT. IgE and tumor necrosis factor in malaria infection. Immunol Lett 1999 65 : 29 33.
27. Virella G, Munoz JF, Galbraith GM, Gissinger C, Chassereau C Lopes-Virella MF. Activation of human monocyte-derived macrophages by immune complexes containing low-density lipoprotein. Clin Immunol Immunopathol 1995 75 : 179 189.
28. Beynon HL, Davies KA, Haskard DO, et al. Erythrocyte complement receptor type 1 and interactions between immune complexes, neutrophils, and endothelium. J Immunol 1994 153 : 3160 3167.
29. Chou YK, Sherwood T Virella G. Erythrocyte-bound immune complexes trigger the release of interleukin-1 from human monocytes. Cell Immunol 1985 91 : 308 314.
30. Dubarry M, Charron C, Habibi B, et al. Quantitation of immunoglobulin classes and subclasses of autoantibodies bound to red cells in patients with and without hemolysis. Transfusion 1993 33 : 466 471.
31. Facer CA. Direct antiglobulin reactions in Gambian children with P. falciparum malaria. III. Expression of IgG subclass determinants and genetic markers and association with anaemia. Clin Exp Immunol 1980 41 : 81 90.
32. Aase A Michaelsen TE. Opsonophagocytic activity induced by chimeric antibodies of the four human IgG subclasses with or without help from complement. Scand J Immunol 1994 39 : 581 587.
33. Schreiber N, Brattig N, Evans J, et al. Cerebral malaria is associated with IgG2 and IgG4 antibody responses to recombinant Plasmodium falciparum RIFIN antigen. Microbes Infect 2006 8 : 1269 1276.
34. Aucan C, Traore Y, Tall F, et al. High immunoglobulin G2 (IgG2) and low IgG4 levels are associated with human resistance to Plasmodium falciparum malaria. Infect Immun 2000 68 : 1252 1258.
35. Yone CL, Kremsner PG Luty AJ. Immunoglobulin G isotype responses to erythrocyte surface-expressed variant antigens of Plasmodium falciparum predict protection from malaria in African children. Infect Immun 2005 73 : 2281 2287.
36. Tangteerawatana P, Montgomery SM, Perlmann H, et al. Differential regulation of IgG subclasses and IgE antimalarial antibody responses in complicated and uncomplicated Plasmodium falciparum malaria. Parasite Immunol 2007 29 : 475 483.
37. Sarthou JL, Angel G, Aribot G, et al. Prognostic value of anti-Plasmodium falciparum-specific immunoglobulin G3, cytokines, and their soluble receptors in West African patients with severe malaria. Infect Immun 1997 65 : 3271 3276.
38. Aribot G, Rogier C, Sarthou JL, et al. Pattern of immunoglobulin isotype response to Plasmodium falciparum blood-stage antigens in individuals living in a holoendemic area of Senegal (Dielmo, west Africa). Am J Trop Med Hyg 1996 54 : 449 457.
39. Ndungu FM, Bull PC, Ross A, et al. Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2. Parasite Immunol 2002 24 : 77 82.
40. Stoute JA. Complement-regulatory proteins in severe malaria: too little or too much of a good thing? Trends Parasitol 2005 21 : 218 223.
41. Bereczky S, Montgomery SM, Troye-Blomberg M, et al. Elevated anti-malarial IgE in asymptomatic individuals is associated with reduced risk for subsequent clinical malaria. Int J Parasitol 2004 34 : 935 942.