Determination of mianserin in human plasma by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI/MS): Application to a bioequivalence study in Chinese volunteers

Journal of Pharmaceutical and Biomedical Analysis

Volumn 47, Issue 4-5, 2008, Pages 994-999

  Xu, Ping ^a   Li, Huan De ^a   Chen, Ben Mei ^b   Ma, Ning ^a   Yan, Miao ^a   Zhu, Yun Gui ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Bioequivalence; Cinnarizine; Determination; LC ESI MS; Mianserin

Indexed keywords

ACETONITRILE; AMMONIUM ACETATE; CINNARIZINE; DIMETHYLCARBINOL; HEXANE; METHANOL DERIVATIVE; MIANSERIN; SODIUM HYDROXIDE;

ACCURACY; ALKALINIZATION; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BLOOD SAMPLING; CHINESE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DETERMINATION; DRUG STABILITY; DRUG STORAGE; ELECTROSPRAY MASS SPECTROMETRY; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; TABLET; THERMOSTABILITY; VALIDATION STUDY; VOLUNTEER;

ACETONITRILES; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; AREA UNDER CURVE; BIOLOGICAL ASSAY; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNARIZINE; CROSS-OVER STUDIES; DRUG STABILITY; FREEZING; HALF-LIFE; HUMANS; MALE; METHANOL; MIANSERIN; MOLECULAR STRUCTURE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TABLETS; THERAPEUTIC EQUIVALENCY; WATER;

EID: 44749094328     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.04.015     Document Type: Article

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