Optimisation of the Caco-2 permeability assay using experimental design methodology

Pharmaceutical Research

Volumn 25, Issue 7, 2008, Pages 1544-1551

  Lakeram, Mark ^a   Lockley, David J ^b   Pendlington, Ruth ^b   Forbes, Ben ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

Apparent permeability; Caco 2; Factorial design; Lipophilic; Parabens

Indexed keywords

2 HEXANONE; 4 HYDROXYBENZOIC ACID ESTER; BOVINE SERUM ALBUMIN; BUTYL PARABEN; ETHYL PARABEN; HEPTYL PARABEN; MANNITOL; METHYL PARABEN; OCTANOIC ACID; OCTYL PARABEN; PROPYL PARABEN;

ANALYSIS OF VARIANCE; ARTICLE; CELL ASSAY; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CELL TRANSPORT; DRUG PENETRATION; EXPERIMENTAL DESIGN; FACTORIAL DESIGN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE FLUID; INTESTINE MUCOSA PERMEABILITY; LIPOPHILICITY; METHODOLOGY; PRIORITY JOURNAL; RESPONSE SURFACE METHOD; SIMULATION; STATISTICAL SIGNIFICANCE;

ALGORITHMS; BODY FLUIDS; CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INTESTINAL ABSORPTION; LIPIDS; PARABENS; PERMEABILITY; SERUM ALBUMIN, BOVINE;

EID: 44749092580     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9556-9     Document Type: Article

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