JAK-2V617F mutation in RARS-t: A target for Imatinib therapy?

Leukemia Research

Volumn 32, Issue 10, 2008, Pages 1636-1637

  Cannizzo, Elisa ^a   Carulli, Giovanni ^a   Azzarà, Antonio ^a   Galimberti, Sara ^a   Zucca, Alessandra ^a   Petrini, Mario ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; IMATINIB; JANUS KINASE 2; PROTEIN TYROSINE KINASE;

AGED; ASTHENIA; BLOOD CELL COUNT; BLOOD TRANSFUSION; BONE MARROW BIOPSY; CASE REPORT; DISEASE COURSE; DRUG TARGETING; ENZYME ACTIVITY; FEMALE; FOLLOW UP; HUMAN; LETTER; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS; THROMBOCYTE COUNT;

AGED; AMINO ACID SUBSTITUTION; ANEMIA, REFRACTORY; ANTINEOPLASTIC AGENTS; FEMALE; HUMANS; JANUS KINASE 2; PIPERAZINES; PLATELET COUNT; POINT MUTATION; PROTEIN KINASE INHIBITORS; PYRIMIDINES;

EID: 44749087319     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2008.03.008     Document Type: Letter

References (5)

1. Shaw G.R. Ringed sideroblasts with thrombocytosis: an uncommon mixed myelodysplastic/myeloproliferative disease of older adults. Br J Haematol 131 October (2) (2005) 180-184
2. Steensma D.P., Dewald G.W., Lasho T.L., et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes. Blood 106 August 15 (4) (2005) 1207-1209 [Epub April 28, 2005]
3. Ceesay M.M., Lea N.C., Ingram W., et al. The JAK2 V617F mutation is rare in RARS but common in RARS-T. Leukemia 20 November (11) (2006) 2060-2061 [Epub August 24, 2006]
4. Szpurka H., Tiu R., Murugesan G., et al. Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation. Blood 108 October 1 (7) (2006) 2173-2181 [Epub June 1, 2006]
5. Finazzi G., and Barbui T. The treatment of polycythaemia vera: an update in the JAK2 era. Int Emerg Med 2 March (1) (2007) 13-18 [Epub March 31, 2007 Review]