Genotoxicity studies on licorice flavonoid oil (LFO)

Food and Chemical Toxicology

Volumn 46, Issue 7, 2008, Pages 2525-2532

  Nakagawa, K ^a   Hidaka, T ^a   Kitano, M ^b   Asakura, M ^c   Kamigaito, T ^c   Noguchi, T ^c   Hosoe, K ^b  

^a KANEKA CORPORATION   (Japan)

^b Frontier Biochemical and Medical Research Laboratories   (Japan)

^c JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

Author keywords

Genotoxicity; Glycyrrhiza glabra; LFO; Licorice ethanol extract; Licorice flavonoid oil

Indexed keywords

LICORICE FLAVONOID OIL; OIL;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; BONE MARROW; CHINESE HAMSTER; CHROMOSOME ABERRATION; CONTROLLED STUDY; DIETARY INTAKE; DOSE RESPONSE; ERYTHROCYTE; ESCHERICHIA COLI; FEEDING; GENOTOXICITY; GLYCYRRHIZA; LIVER; LUNG ALVEOLUS CELL; MUTATIONAL ANALYSIS; NONHUMAN; SALMONELLA TYPHIMURIUM;

ADMINISTRATION, ORAL; ANIMALS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; ESCHERICHIA COLI; FLAVONOIDS; GLYCYRRHIZA; HUMANS; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS; PLANT OILS; RATS; RATS, INBRED F344; SALMONELLA TYPHIMURIUM;

ANIMALIA; CRICETULUS GRISEUS; ESCHERICHIA COLI; GLYCYRRHIZA; GLYCYRRHIZA GLABRA; RATTUS; SALMONELLA TYPHIMURIUM;

EID: 44749083878     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.04.008     Document Type: Article

References (25)

1. Ames B.N., McCann J., and Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat. Res. 31 (1975) 347-364
2. Aoki F., Honda S., Kishida H., Kitano M., Arai N., Tanaka H., Yokota S., Nakagawa K., Asakura T., Nakai Y., and Mae T. Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice. Biosci. Biotechnol. Biochem. 71 (2007) 206-214
3. Aoki F., Nakagawa K., Kitano M., Ikematsu H., Nakamura K., Yokota S., Tominaga Y., Arai N., and Mae T. Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridine in healthy humans. J. Am. Coll. Nutr. 26 (2007) 209-218
4. Belinky P.A., Aviram M., Fuhrman B., Rosenblat M., and Vaya J. The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. Atherosclerosis 137 (1998) 49-61
5. Charles G.D., Linscombe V.A., Tornesi B., Mattsson J.L., and Gollapudi B.B. An in vitro screening paradigm for extracts of whole food for detection of potential toxicants. Food and Chemical Toxicology 40 (2002) 1391-1402
6. Fukai T., Marumo A., Kaitou K., Kanda T., Terada S., and Nomura T. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 74 (2002) 720-724
7. Fukai T., Marumo A., Kaitou K., Kanda T., Terada S., and Nomura T. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 71 (2002) 1449-1463
8. Furman B., Buch S., Vaya J., Belinky P.A., Coleman R., Hayek T., and Aviram M. Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am. J. Clin. Nutr. 66 (1997) 267-275
9. Furman B., Volkova N., Kaplan M., Presser D., Attias J.R., Hayek T., and Aviram M. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid level and decreased systolic blood pressure. Nutrition 18 (2002) 268-273
10. Hayashi M., Kishi M., Sofuni T., and Ishidate M. Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals. Food Chem. Toxic. 26 (1988) 487-500
11. Higgins G.M., and Anderson R.M. Experimental pathology of the liver: restoration of the liver of the white rat following partial surgical removal. Arch. Pathol. 12 (1931) 186-202
12. Ishidate M.J.R., Sofuni T., Yoshikawa K., Hayashi M., Nohmi T., Sawada M., and Matsuoka M. Primary mutagenicity screening of food additives currently used in Japan. Food Chem. Toxic. 22 (1984) 623-636
13. Ito C., Oi N., Hashimoto T., Nakabayashi H., Aoki F., Tominaga Y., Yokota S., Hosoe K., and Kanazawa K. Absorption of dietary licorice isoflavan glabridin to blood circulation in rats. J. Nutr. Sci. Vitaminol. 53 (2007) 358-365
14. Japanese Environmental Mutagen Society/Mammalian Mutagenicity Study Group (Ed.), 1988. Atlas of chromosomal aberrations induced by chemicals, Asakura Publishing Co. Ltd., Tokyo (in Japanese).
15. Kassie F., Parzefall W., Musk S., Johnson I., Lamprecht G., Sontag G., and Knasmuller S. Genotoxic effects of crude juices from Brassica vegetables and juices and extracts from phytoparmaceutical preparations and spices of cruciferous plants origin in bacterial and mammalian cells. Chemico-Biol. Interact. 102 (1996) 1-16
16. Kastenbaum M.T., and Bowman K.O. Tables for determining the statistical significance of mutation frequencies. Mutat. Res. 9 (1970) 527-549
17. Morimoto I., Watanabe F., Osawa T., Okitsu T., and Kada T. Mutagenicity screening of crude drugs with Bacillus subtilis rec-assay and Salmonella/microsome reversion assay. Mutat. Res. 97 (1982) 811-102
18. Nakagawa K., Kishida H., Arai N., Nishiyama T., and Mae T. Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-Ay mice. Biol. Pharm. Bull. 27 (2004) 1775-1778
19. Nakagawa, K., Kitano, M., Kishida, H., Nabae, K., Kawabe, M., Hosoe, K., in press. 90-Day repeated dose toxicity study of licorice flavonoid oil (LFO) in rats. Food Chem. Toxicol.
20. Noguchi T., Asakura M., Sugiyama T., and Matsushima T. N-Nitroso-di-n-propylamine induces micronuclei in partially hepatectomized rat liver but not in mouse bone marrow cells. Mamm. Mutagen. Study Group Commun. (MMS Com) 2 (1994) 79-82
21. Rosenblat M., Belinky P., Vaya J., Levy R., Hayek T., Coleman R., Merchav S., and Aviram M. Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. J. Biol. Chem. 274 (1999) 13790-13799
22. Sato J., Goto K., Nanjo F., Kawai S., and Kurata K. Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola. J. Biosci. Bioeng. 90 (2000) 442-446
23. The Environmental Health Bureau, Ministry of Health and Welfare (Ed.) 1996. Guidelines for designation of food additives and for revision of standards for use of food additives, Japan Food Additives Association, Tokyo (in Japanese).
24. Tominaga Y., Mae T., Kitano M., Sakamoto Y., Ikematsu H., and Nakagawa K. Licorice flavonoid oil effects body weight loss by reduction of body fat mass in overweight subjects. J. Health Sci. 52 (2006) 672-683
25. Yokota T., Nishio H., Kubota Y., and Mizoguchi M. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. Pigment Cell Res. 11 (1998) 355-361