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Recently released guidelines to help guide the use of biomarkers in patients with acute coronary syndromes
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Morrow DA, Cannon CP, Jesse RL, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Circulation 2007; 115:e356-e375. Recently released guidelines to help guide the use of biomarkers in patients with acute coronary syndromes.
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for the Fragmin in Unstable Coronary Artery Disease (FRISC) Study Group
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Wong, G.C.1
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Evaluation of the AccuTnI cardiac troponin I assay for risk assessment in acute coronary syndromes
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Development and preliminary clinical validation of a high sensitivity assay for cardiac troponin using a capillary flow (single molecule) fluorescence detector
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in press, Data demonstrating that elevated levels of thrombus precursor protein are associated with a higher risk of death and recurrent events in patients with ACS. The marker does not appear to correlate strongly with existing markers, which may help to explain its incremental utility for risk stratification
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Mega J, Morrow DA, De Lemos JA, et al. Thrombus precursor protein (TpP) and clinical outcomes in patients with acute coronary syndromes. J Am Coll Cardiol (in press). Data demonstrating that elevated levels of thrombus precursor protein are associated with a higher risk of death and recurrent events in patients with ACS. The marker does not appear to correlate strongly with existing markers, which may help to explain its incremental utility for risk stratification.
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Morrow DA, Wang Y, Croce K, et al. Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial. Am Heart J 2008; 155:49-55. MRP-8/14 was identified through the process of transcript profiling of platelets in patients with ACS. This manuscript demonstrates an association between MRP-8/14 and the risk of death or MI after ACS.
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Morrow DA, Wang Y, Croce K, et al. Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial. Am Heart J 2008; 155:49-55. MRP-8/14 was identified through the process of transcript profiling of platelets in patients with ACS. This manuscript demonstrates an association between MRP-8/14 and the risk of death or MI after ACS.
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