Polymer microchip integrated with nano-electrospray tip for electrophoresis-mass spectrometry

Sensors and Actuators, B: Chemical

Volumn 132, Issue 2, 2008, Pages 368-373

  Shinohara, Hidetoshi ^a   Suzuki, Takafumi ^a   Kitagawa, Fumihiko ^b   Mizuno, Jun ^a   Otsuka, Koji ^b   Shoji, Shuichi ^a  

^a WASEDA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Cyclo olefin polymer; Electrospray ionization; Mass spectrometry; Microchip electrophoresis

Indexed keywords

AMINO ACIDS; ELECTROCHEMISTRY; ELECTROPHORESIS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION BEAMS; ISOMERS; MASS SPECTROMETERS; MASS SPECTROMETRY; MICROFLUIDICS; NITROGEN COMPOUNDS; OLEFINS; PESTICIDES; POLYMERS; SEPARATION; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; SPRAYING;

AND DETECTION; ARGININE (ARG); CYCLO OLEFIN POLYMERS; DIRECT BONDING; ELECTROPHORETIC SEPARATIONS; ELECTROSPRAY (ES); ELECTROSPRAY IONIZATION (ESI); ELECTROSPRAY TIP; ELSEVIER (CO); EMITTER TIPS; HOT EMBOSSING; LOW FLOW RATE; MASS SPECTROMETRIC (MS) DETECTION; MICROCHIP (CO); MICROCHIP ELECTROPHORESIS (MCE);

INTEGRATED CIRCUITS;

EID: 44649189102     PISSN: 09254005     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.snb.2007.09.071     Document Type: Article

References (22)

1. Becker H., and Heim U. Hot embossing as a method for the fabrication of polymer high aspect ratio structures. Sens. Actuators A 83 (2000) 130-135
2. Kelly R.T., and Woolley A.T. Thermal bonding of polymeric capillary electrophoresis microdevices in water. Anal. Chem. 75 (2003) 1941-1945
3. Chen Z., Gao Y., Lin J., Su R., and Xie Y. Vacuum-assisted thermal bonding of plastic capillary electrophoresis microchip imprinted with stainless steel template. J. Chromatogr. A 1038 (2004) 239-245
4. McCormick R.M., Nelson R.J., Amigo M.G.A., Benvegnu D.J., and Hooper H.H. Microchannel electrophoretic separations of DNA in injection-molded plastic substrates. Anal. Chem. 69 (1997) 2626-2630
5. Svedberg M., Pettersson A., Nilsson S., Bergquist J., Nyholm L., Nikolajeff F., and Markides K. Sheathless electrospray from polymer microchips. Anal. Chem. 75 (2003) 3934-3940
6. Dang F., Tabata O., Kurokawa M., Ewis A.A., Zhang L., Yamaoka Y., Shinohara S., Shinohara Y., Ishikawa M., and Baba Y. High-performance genetic analysis on microfabricated capillary array electrophoresis plastic chips fabricated by injection molding. Anal. Chem. 77 (2005) 2140-2146
7. Duffy D.C., McDonald J.C., Schueller O.J.A., and Whitesides G.M. Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal. Chem. 70 (1998) 4974-4984
8. Slentz B.E., Penner N.A., Lugowska E., and Regnier F. Nanoliter capillary electrochromatography columns based on collocated monolithic support structures molded in poly(dimethylsiloxane). Electrophoresis 22 (2001) 3736-3743
9. Chiou C.H., Lee G.B., Hsu H.T., Chen P.W., and Liao P.C. Microdevices integrated with microchannels and electrospray nozzles using PDMS casting techniques. Sens. Actuators B 86 (2002) 280-286
10. Mizuno J., Ishida H., Farrens S., Dragoi V., Shinohara H., Suzuki T., Ishizuka M., Glinsner T., Lindner F.P., and Shoji S. Cyclo-olefin polymer direct bonding using low temperature plasma activation bonding. Tech. Digest, IEEE Int. Conf. Solid-state Sens. Actuators and Microsystems. Seoul, Korea, June 5-9 (2005)
11. Ishizuka M., Suzuki T., Shinohara H., Houjou H., Motokawa S., Mizuno J., Momma T., Osaka T., and Shoji S. Cost effective plastic micro direct methanol fuel cell (μDMFC). Tech. Digest, Int. Conf. Miniaturized Systems for Chemistry and Life Sciences. Boston, USA, October 9-13 (2005)
12. Kitagawa F., Suzuki T., Mizuno J., Shoji S., and Otsuka K. High performance electrophoretic analysis on cycloolefin polymer microchips. Tech. Digest, Int. Conf. Miniaturized Systems for Chemistry and Life Sciences. Tokyo, Japan, November 5-9 (2006)
13. Xue Q., Foret F., Dunayevskiy Y.M., Zavracky P.M., McGruer N.E., and Karger B.L. Multichannel microchip electrospray mass spectrometry. Anal. Chem. 69 (1997) 426-430
14. Ramsey R.S., and Ramsey J.M. Generating electrospray from microchip devices using electroosmotic pumping. Anal. Chem. 69 (1997) 1174-1178
15. Zhang B., Foret F., and Karger B. High-throughput microfabricated CE/ESI-MS: automated sampling from a microwell plate. Anal. Chem. 73 (2001) 2675-2681
16. Tachibana Y., Otsuka K., Terabe S., Arai A., Suzuki K., and Nakamura S. Robust and simple interface for microchip electrophoresis-mass spectrometry. J. Chromatogr. A 1011 (2003) 181-192
17. Tachibana Y., Otsuka K., Terabe S., Arai A., Suzuki K., and Nakamura S. Effects of the length and modification of the separation channel on microchip electrophoresis-mass spectrometry for analysis of bioactive compounds. J. Chromatogr. A 1025 (2004) 287-296
18. Li J., Wang C., Kelly J.F., Harrison D.J., and Thibault P. Rapid and sensitive separation of trace level protein digests using microfabricated devices coupled to a quadrupole-time-of-flight mass spectrometer. Electrophoresis 21 (2000) 198-210
19. Arscott S., Gac S.L., Druon C., Tabourier P., and Rolando C. A micro-nib nanoelectrospray source for mass spectrometry. Sens. Actuators B 98 (2004) 140-147
20. Shinohara H., Mizuno J., and Shoji S. Fabrication of a microchannel device by hot embossing and direct bonding of poly(methyl methacrylate). Jpn. J. Appl. Phys. 46 (2007) 3661-3664
21. Shinohara H., Mizuno J., and Shoji S. Low-temperature direct bonding of poly(methyl methacrylate) for polymer microchips. IEEJ Trans. 2 (2007) 301-306
22. Sze A., Erickson D., Ren L., and Li D. Zeta-potential measurement using the Smoluchowski equation and the slope of the current-time relationship in electroosmotic flow. J. Colloid. Interface Sci. 261 (2003) 402-410