Safety Update on Recombinant Factor VIIa in the Treatment of Congenital and Acquired Hemophilia

Seminars in Hematology

Volumn 45, Issue SUPPL. 1, 2008, Pages

  Abshire, Thomas ^a  

^a AFLAC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING INHIBITOR; HEMOSTATIC AGENT; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBIN; THROMBOPLASTIN;

ANTICOAGULATION; ARTICLE; CLINICAL TRIAL; CONGENITAL BLOOD CLOTTING DISORDER; DEEP VEIN THROMBOSIS; DISEASE PREDISPOSITION; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG BINDING; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG RESEARCH; DRUG SAFETY; HEART INFARCTION; HEMOPHILIA; HEMOPHILIA A; HEMOPHILIA B; HUMAN; LUNG EMBOLISM; OFF LABEL DRUG USE; PRIORITY JOURNAL; RISK FACTOR; STROKE; THROMBOEMBOLISM; THROMBOPHLEBITIS; THROMBOSIS; TREATMENT INDICATION;

BLOOD COAGULATION FACTORS; FACTOR VIIA; HEMOPHILIA A; HEMOPHILIA B; HUMANS; RECOMBINANT PROTEINS; THROMBOEMBOLISM;

EID: 44649180990     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2008.03.006     Document Type: Article

References (8)

1. Abshire T., and Kenet G. Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors. J Thromb Haemost 2 (2004) 899-909
2. Aledort L.M. Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity. J Thromb Haemost 2 (2004) 1700-1708
3. O'Connell K.A., Wood J.J., Wise R.P., Lozier J.N., and Braun M.M. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA 295 (2006) 293-298
4. Hoffman M., Monroe III D.M., and Roberts H.R. Activated factor VII activates factors IX and X on the surface of activated platelets: Thoughts on the mechanism of action of high-dose activated factor VII. Blood Coagul Fibrinolysis 9 suppl 1 (1998) S61-S65
5. Roberts H.R., Monroe III D.M., and Hoffman M. Safety profile of recombinant factor VIIa. Semin Hematol 41 suppl 1 (2004) 101-108
6. Allen G.A., Monroe III D.M., Roberts H.R., and Hoffman M. The effect of factor X level on thrombin generation and the procoagulant effect of activated factor VII in a cell-based model of coagulation. Blood Coagul Fibrinolysis 11 suppl 1 (2000) S3-S7
7. Sallah S., Isaksen M., Seremetis S., and Rojkjaer L. Comparative thrombotic event incidence after infusion of recombinant factor VIIa vs. factor VIII inhibitor bypass activity-A rebuttal. J Thromb Haemost 3 (2005) 820-822
8. Hay C.R. Thrombosis and recombinant factor VIIa. J Thromb Haemost 2 (2004) 1698-1699