β2-adrenergic receptor signaling mediates corneal epithelial wound repair

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 5, 2008, Pages 1857-1863

  Ghoghawala, Shahed Y ^a   Mannis, Mark J ^a   Pullar, Christine E ^a,b   Rosenblatt, Mark I ^a   Isseroff, Rivkah ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BETA 2 ADRENERGIC RECEPTOR; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; SODIUM CHLORIDE; TIMOLOL; TYROSINE 3 MONOOXYGENASE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; CATECHOLAMINE SYNTHESIS; CELL MIGRATION; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA INJURY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENE DELETION; IMMUNOBLOTTING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RATING SCALE; SIGNAL TRANSDUCTION; WOUND HEALING; ANIMAL; CELL MOTION; DRUG EFFECT; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CELL MOVEMENT; EPINEPHRINE; EPITHELIUM, CORNEAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; IMMUNOBLOTTING; ISOPROTERENOL; MALE; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; TIMOLOL; TYROSINE 3-MONOOXYGENASE; WOUND HEALING;

EID: 44649172721     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-0925     Document Type: Article

References (39)

1. ReidyJJ, Zarzour J, Thompson HW, Beuerman RW. Effect of topical beta blockers on corneal epithelial wound healing in the rabbit. Br J Ophthalmol. 1994;78(5):377-380.
2. Arend O, Harris A, Arend S, Remky A, Martin BJ. The acute effect of topical beta-adrenoreceptor blocking agents on retinal and optic nerve head circulation. Acta Ophthalmol Scand. 1998;76(1):43-49.
3. Tamaki Y, Araie M, Tomita K, Nagahara M, Tomidokoro A. Effect of topical beta-blockers on tissue blood flow in the human optic nerve head. Curr Eye Res. 1997;16(11):1102-1110.
4. Walkenbach RJ, Gibbs SR, Bylund DB, Chao WT. Characteristics of beta-adrenergic receptors in bovine corneal epithelium: comparison of fresh tissue and cultured cells. Biochem Biophys Res Com mun. 1984;121(2):664-672.
5. Kahle G, Kaulen P, Wollensak J. Quantitative autoradiography of beta-adrenergic receptors in rabbit eyes. Exp Eye Res. 1990;51(5):503-507.
6. Elena PP, Kosina-Boix M, Moulin G, Lapalus P. Autoradiographic localization of beta-adrenergic receptors in rabbit eye. Invest Ophthalmol VisSci. 1987;28(8):1436-1441.
7. Elena PP, Denis P, Kosina-Boix M, Saraux H, Lapalus P. Beta adrenergic binding sites in the human eye: an autoradiographic study. J Ocul Pharmacol. 1990;6(2):143-149.
8. Cooper RL, Constable IJ, Davidson L. Aqueous humor catecholamines. Curr Eye Res. 1984;3(6):809-813.
9. Trope GE, Rumley AG. Catecholamine concentrations in tears. Exp Eye Res. 1984;39(3):247-250.
10. Muller LJ, Marfurt CF, Kruse F, Tervo TM. Corneal nerves: structure, contents and function. Exp Eye Res. 2003;76(5):521-542.
11. Marfurt CF, Ellis LC. Immunohistochemical localization of tyrosine hydroxylase in corneal nerves. J Comp Neurol. 1993;336(4):517-531.
12. Marfurt CF. Sympathetic innervation of the rat cornea as demonstrated by the retrograde and anterograde transport of horseradish peroxidase-wheat germ agglutinin. J Comp Neurol. 1988;268(2): 147-160.
13. Cavallotti C, Frati A, Sagnelli P, Pescosolido N. Re-evaluation and quantification of the different sources of nerve fibres supplying the rat eye. J Anat. 2005;206(3):217-224.
14. 3H]quinuclidinyl benzilate to intact cells of cultured corneal epithelium. Metab Pediatr Syst Ophthalmol. 1982;6(2):75-86.
15. Haruta Y, Ohashi Y, Matsuda S. Corneal epithelial deficiency induced by the use of beta-blocker eye drops. Eur J Ophthalmol. 1997;7(4):334-339.
16. Liu GS, Trope GE, Basu PK. Beta adrenoceptors and regenerating corneal epithelium. J Ocul Pharmacol. 1990;6(2):101-112.
17. Murphy CJ, Campbell S, Araki-Sasaki K, Marfurt CF. Effect of norepinephrine on proliferation, migration, and adhesion of SV-40 transformed human corneal epithelial cells. Cornea. 1998;17(5):529-536.
18. Perez E, Lopez-Briones LG, Gallar J, Belmonte C. Effects of chronic sympathetic stimulation on corneal wound healing. Invest Ophthalmol VisSci. 1987;28(2):221-224.
19. Chen J, Hoffman BB, Isseroff RR. Beta-adrenergic receptor activation inhibits keratinocyte migration via a cyclic adenosine monophosphate-independent mechanism. J Invest Dermatol. 2002;119(6):1261-1268.
20. Pullar CE, Chen J, Isseroff RR. PP2A activation by beta2-adrenergic receptor agonists: novel regulatory mechanism of keratinocyte migration. J Biol Chem. 2003;278(25):22555-22562.
21. Pullar CE, Grahn JC, Liu W, Isseroff RR. Beta2-adrenergic receptor activation delays wound healing. FASEB J 2006;20(1):76-86.
22. Pullar CE, Rizzo A, Isseroff RR. β-Adrenergic receptor antagonists accelerate skin wound healing: evidence for a catecholamine synthesis network in the epidermis. J Biol Chem. 2006;281(31): 21225-21235.
23. Pullar CE, Zhao M, Song B, et al. Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous adrenergic network within the corneal epithelium. J Cell Physiol. 2007;211(1):261-272.
24. Chruscinski AJ, Rohrer DK, Schauble E, Desai KH, Bernstein D, Kobilka BK. Targeted disruption of the beta2 adrenergic receptor gene. J Biol Chem. 1999;274(24):16694-16700.
25. Kawakita T, Espana EM, He H, Yeh LK, Liu CY, Tseng SC. Calcium- induced abnormal epidermal-like differentiation in cultures of mouse corneal-limbal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45(10):3507-3512.
26. Fang KS, Ionides E, Oster G, Nuccitelli R, Isseroff RR. Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields. J Cell Sci. 1999;112(pt 12):1967-1978.
27. Ghoghawala SY, Mannis MJ, MurphyCJ, Rosenblatt MI, IsseroffRR. Economical LED based, real-time, in vivo imaging of murine corneal wound healing. Exp Eye Res. 2007;84(6):1031-1038.
28. Schmucker C, Schaeffel F. A paraxial schematic eye model for the growing C57BL/6 mouse. Vis Res. 2004;44(16):1857-1867.
29. Crosson CE, Klyce SD, Beuerman RW. Epithelial wound closure in the rabbit cornea: a biphasic process. Invest Ophthalmol Vis Sci. 1986;27(4):464- 473.
30. Gipson IK, Spurr-Michaud S, Tisdale A, Elwell J, Stepp MA. Redistribution of the hemidesmosome components alpha 6 beta 4 integrin and bullous pemphigoid antigens during epithelial wound healing. Exp Cell Res. 1993;207(1):86-98.
31. Zeigler ME, Chi Y, Schmidt T, Varani J. Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal kera-tinocytes. J Cell Physiol. 1999;180(2):271-284.
32. Glading A, Chang P, Lauffenburger DA, Wells A. Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. J Biol Chem. 2000;275(4):2390-2398.
33. Wang E, Zhao M, Forrester JV, McCaig CD. Electric fields and MAP kinase signaling can regulate early wound healing in lens epithelium. Invest Ophthalmol Vis Sci. 2003;44(1):244-249.
34. Shanley LJ, McCaig CD, Forrester JV, Zhao M. Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium. Invest Ophthalmol VisSci. 2004;45(4): 1088-1094.
35. Xu KP, Riggs A, Ding Y, Yu FS. Role of ErbB2 in corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2004;45(12):4277-4283.
36. Imayasu M, Shimada S. Phosphorylation of MAP kinase in corneal epithelial cells during wound healing. Curr Eye Res. 2003;27(3):133-141.
37. Zhou Z, Althin R, Sforzolini BS, Dhawan R. Persistency and treatment failure in newly diagnosed open angle glaucoma patients in the United Kingdom. Br J Ophthalmol. 2004;88(11):1391-1394.
38. Kacere RD, Dolan JW, Brubaker RF. Intravenous epinephrine stimulates aqueous formation in the human eye. Invest Ophthalmol Vis Sci. 1992;33(10):2861-2865.
39. Schallreuter KU, Wood JM, Lemke R, et al. Production of catecholamines in the human epidermis. Biochem Biophys Res Commun. 1992;189(1):72-78.