Observer design and tuning for biomass growth and kLa using online and offline measurements

Journal of Process Control

Volumn 18, Issue 7-8, 2008, Pages 621-631

  Soons, Z I T A ^a,b   Shi, J ^a   Stigter, J D ^a   van der Pol, L A ^b   van Straten, G ^a   van Boxtel, A J B ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b NETHERLANDS VACCINE INSTITUTE   (Netherlands)

Author keywords

Bioreactor; Extended Kalman filter; Online and offline measurements

Indexed keywords

BIOMASS; BIOREACTORS; EXTENDED KALMAN FILTERS; GROWTH KINETICS; ONLINE SYSTEMS;

BIOMASS GROWTH; BIOPHARMACEUTICAL PRODUCTION; ONLINE AND OFFLINE MEASUREMENTS;

DRUG PRODUCTS PLANTS;

EID: 44649172552     PISSN: 09591524     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jprocont.2007.12.008     Document Type: Article

References (33)

1. R. Neeleman, C. Beuvery, D. Vries, G. Van Straten, A.J.B. Van Boxtel, Dual-substrate feedback control of the specific growth-rate in vaccine production, in: CAB9 - Computer Applications on Biotechnology, Nancy, France, 2004.
2. Bastin G., and Dochain D. On-line Estimation and Adaptive Control of Bioreactors (1990), Elsevier, Amsterdam
3. La estimation using online and offline measurements, in: CAB10 - Computer Applications on Biotechnology, Cancun, Mexico, 2007.
4. Lübbert A., and Jørgensen S.B. Bioreactor performance: a more scientific approach for practice. J. Biotechnol. 85 (2001) 187-212
5. Jenzsch M., Simutis R., Eisbrenner G., Stückrath I., and Lübbert A. Estimation of biomass concentrations in fermentation processes for recombinant protein production. Bioprocess Biosyst. Eng. 29 (2006) 19-27
6. Wilson D.I., Agarwal M., and Rippin D.W.T. Experiences implementing the extended Kalman filter on an industrial batch reactor. Comput. Chem. Eng. 22 (1998) 1653-1672
7. Perrier M., Feyo de Azevedo S., Ferreira E.C., and Dochain D. Tuning of observer-based observers: theory and application to the on-line estimation of kinetic parameters. Control Eng. Practice 8 (2000) 377-388
8. Doran P.M. Bioprocess Engineering Principles (1995), Academic Press, San Diego
9. Sabra W., Kim E., and Zeng A. Physiological responses of pseudomonas aeruginosa PAO1 to oxidative stress in controlled microaerobic and aerobic cultures. Microbiology 148 (2002) 3195-3202
10. Galaction A.I., Cascaval D., Oniscu C., and Turnea M. Prediction of oxygen mass transfer coefficients in stirred bioreactors for bacteria, yeasts and fungus broths. Biochem. Eng. J. 20 (2004) 85-94
11. Dondo R., and Marqués D. Simulation results for on-line optimization of a batch bioreactor using nonlinear filtering and optimal control. ISA Trans. 42 (2003) 289-303
12. Myers M.A., Kang S., and Luecke R.H. State estimation and control for systems with delayed off-line measurements. Comput. Chem. Eng. 20 (1995) 585-588
13. Tatiraju S., Soroush M., and Mutharasan R. Multi-rate nonlinear state and parameters estimation in a bioreactor. Biotechnol. Bioeng. 63 (1999) 22-32
14. Mutha R.K., Cluett W.R., and Penlidis A. A new multirate-measurement-based estimator: emulsion copolymerization batch reactor case study. Ind. Eng. Chem. Res. 36 (1997) 1036-1047
15. Lubenova V., Rocha I., and Ferreira E.C. Estimation of multiple biomass growth rates and biomass concentration in a class of bioprocesses. Bioprocess Biosyst. Eng. 25 (2003) 395-406
16. Gudi R.D., Shah S.L., Gray M.R., and Aran P.K.Y. Adaptive multirate estimation and control of nutrient levels in a fed-batch fermentation using off-line and on-line measurements. Canadian J. Chem. Eng. 75 (1997) 562-573
17. Gudi R.D., Shah S.L., and Gray M.R. Adaptive multirate state and parameter estimation strategies with application to a bioreactor. AIChE J. 41 (1995) 2451-2464
18. M.N. Ignatova, Adaptive biomass observer on the basis of measurements of oxygen, in: 11th Mediterranean Conference on Control and Automations, Rhodes, Greece, 2003.
19. Neeleman R., Joerink M., and Van Boxtel A.J.B. Dual substrate utilisation by Bordetella pertussis. Appl. Microbiol. Biotechnol. 57 (2001) 489-493
20. R. Neeleman, Biomass Performance - Monitoring and Control in Bio-pharmaceutical Production, Thesis, Wageningen University, The Netherlands, 2002.
21. Soons Z.I.T.A., Voogt J.A., Van Straten G., and Van Boxtel A.J.B. Constant specific growth rate in fed-batch cultivation of Bordetella pertussis using adaptive control. J. Biotechnol. 125 (2006) 252-268
22. Thalen M., Van Den IJssel J., Jiskoot W., Zomer B., Roholl P., De Gooijer C., Beuvery C., and Tramper H. Rational medium design for Bordetella pertussis; basic metabolism. J. Biotechnol. 75 (1999) 147-159
23. Wang N.S., and Stephanopoulos G.N. Computer applications to fermentation processes. CRC Crit. Rev. Biotechnol. 2 (1984) 1-90
24. Lewis F.J. Optimal Estimation (1986), John Wiley and Sons, New York
25. Ljung L. Asymptotic behaviour of the extended Kalman filter as a parameter estimator for linear systems. IEEE Trans. Automat. Control 24 (1979) 36-50
26. Keesman K.J. State and parameter estimation in biotechnical batch reactors. Control Eng. Practice 10 (2002) 219-225
27. Gee D.A., and Ramirez W.F. On-line state estimation and parameter identification for batch fermentation. Biotechnol. Prog. 12 (1996) 132-140
28. E.D. Sontag, Input to state stability and related notions, in: Proceedings of Symposium Chemical Process Control VI, Tueson, 2001, pp. 109-120.
29. Dochain D. State and parameter estimation in chemical and biochemical processes: a tutorial. J. Process Control 13 (2003) 801-818
30. Nise N.S. Control Systems Engineering (2000), John Wiley & Sons, USA
31. November E.J., and van Impe J.F. The tuning of a model-based estimator for the specific growth rate of Candida utilis. Bioprocess Biosyst. Eng. 25 (2002) 1-12
32. Pirt S.J. Maintenance energy: a general model for energy-limited and energy-sufficient growth. Arch. Microbiol. 133 (1982) 300-302
33. Van't Riet K., and Tramper J. Basis Bioreactor Design (1991), Marcel Dekker, New York