Neonatal thrombocytopenia

Seminars in Fetal and Neonatal Medicine

Volumn 13, Issue 4, 2008, Pages 256-264

  Roberts, Irene ^a   Murray, Neil A ^b  

^a IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Fetal thrombocytopenia; Neonatal alloimmune thrombocytopenia (NAIT); Neonatal thrombocytopenia; Platelet transfusion

Indexed keywords

ALLOIMMUNITY; ARTICLE; BLEEDING TENDENCY; DISEASE CLASSIFICATION; FETUS HYPOXIA; HUMAN; INTRAUTERINE GROWTH RETARDATION; NEONATAL HEMORRHAGE; NEWBORN; NEWBORN DISEASE; PREMATURITY; PRENATAL CARE; PREVALENCE; RISK FACTOR; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA;

FEMALE; HUMANS; INFANT, NEWBORN; PLATELET TRANSFUSION; PREGNANCY; PRENATAL CARE; PREVALENCE; THROMBOCYTOPENIA;

EID: 44649167524     PISSN: 1744165X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.siny.2008.02.004     Document Type: Article

References (47)

1. Murray N.A., Howarth L.J., McCloy M.P., et al. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med 12 (2002) 35-41
2. Garcia M.G., Duenas E., Sola M.C., et al. Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit. J Perinatol 21 (2001) 415-420
3. Del Vecchio A., Sola M.C., Theriaque D.W., et al. Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. Transfusion 41 (2001) 803-808
4. Bonifacio L., Petrova A., Nanjundaswamy S., and Mehta R. Thrombocytopenia related neonatal outcome in preterms. Indian J Pediatr 74 (2007) 269-274
5. Kenton A.B., Hegemier S., Smith E.O., et al. Platelet transfusions in infants with necrotizing enterocolitis do not lower mortality but may increase morbidity. J Perinatol 25 (2005) 173-177
6. Pahal G., Jauniaux E., Kinnon C., Thrasher A.J., and Rodeck C.H. Normal development of human fetal hematopoiesis between eight and seventeen weeks' gestation. Am J Obstet Gynecol 183 (2000) 1029-1034
7. Holmberg L., Gustavii B., and Jonsson A. A prenatal study of fetal platelet count and size with application to the fetus at risk of Wiskott Aldrich syndrome. J Pediatr 102 (1983) 773-781
8. Forestier F., Daffos F., and Galacteros F. Haematological values of 163 normal fetuses between 18 and 30 weeks of gestation. Pediatr Res 20 (1986) 342-346
9. Forestier F., Daffos F., Catherine N., Renard M., and Andreux J.P. Developmental hematopoiesis in normal human fetal blood. Blood 77 (1991) 2360-2363
10. Burrows R.F., and Kelton J.G. Incidentally detected thrombocytopenia in healthy mothers and their infants. N Engl J Med 319 (1988) 142-145
11. Burrows R.F., and Kelton J.G. Thrombocytopenia at delivery: a prospective survey of 6715 deliveries. Am J Obstet Gynecol 162 (1990) 731-734
12. Burrows R.F., and Kelton J.G. Fetal thrombocytopenia and its relation to maternal thrombocytopenia. N Engl J Med 329 (1993) 1463-1466
13. Sainio S., Jarvenpaa A.-S., Renlund M., et al. Thrombocytopenia in term infants: a population-based study. Obstet Gynecol 95 (2000) 441-446
14. Christensen R.D., Henry E., Wiedmeier S.E., et al. Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system. J Perinatol 26 (2006) 348-353
15. Castle V., Andrew M., Kelton J., et al. Frequency and mechanism of neonatal thrombocytopenia. J Pediatr 108 (1986) 749-755
16. Mehta P., Rohitkumar V., Neumann L., and Karpatkin M. Thrombocytopenia in the high risk infant. J Pediatr 97 (1980) 791-794
17. Murray N.A., and Roberts I.A.G. Circulating megakaryocytes and their progenitors in early thrombocytopenia in preterm neonates. Pediatr Res 40 (1996) 112-119
18. Watts T.L., and Roberts I.A.G. Haematological abnormalities in the growth-restricted infant. Semin Neonatol 4 (1999) 41-54
19. Roberts I.A.G., and Murray N.A. Neonatal thrombocytopenia: new insights into pathogenesis and implications for clinical management. Curr Opin Pediatr 13 (2001) 16-21
20. Salvesen D.R., Brudenell J.M., Snijders R.J., Ireland R.M., and Nicolaides K.H. Fetal plasma erythropoietin in pregnancies complicated by maternal diabetes mellitus. Am J Obstet Gynecol 168 (1993) 88-94
21. Watts T.L., Murray N.A., and Roberts I.A.G. Thrombopoietin has a primary role in the regulation of platelet production in preterm babies. Pediatr Res 46 (1999) 28-32
22. Ghevaert C., Campbell K., Walton J., et al. Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia. Transfusion 47 (2007) 901-910
23. Ouwehand W.H., Smith G., and Ranasinghe E. Management of severe alloimmune thrombocytopenia in the newborn. Arch Dis Child Fetal Neonatal 82 (2000) F173-F175
24. Bussel J.B., and Primiani A. Fetal and neonatal alloimmune thrombocytopenia: progress and ongoing debates. Blood Rev 22 (2008) 33-52
25. Williamson L.M., Hackett G., Rennie J., et al. The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening. Blood 92 (1998) 2280-2287
26. Mueller-Eckhardt C., Kiefel V., Grubert A., et al. 348 cases of suspected neonatal alloimmune thrombocytopenia. Lancet 1 (1989) 363-366
27. Bussel J.B., Zacharoulis S., Kramer K., et al. Clinical and diagnostic comparison of neonatal alloimmune thrombocytopenia to non-immune cases of thrombocytopenia. Pediatr Blood Cancer 45 (2005) 176-183
28. Giovangrandi Y., Daffos F., Kaplan C., et al. Very early intracranial haemorrhage in alloimmune fetal thrombocytopenia. Lancet 336 (1990) 310
29. Bussel J.B., Zabusky M.R., Berkowitz R.L., and McFarland J.G. Fetal alloimmune thrombocytopenia. N Engl J Med 337 (1997) 22-26
30. Singh S.A., Pollard J., and Singhal N. Fetomaternal alloimmune thrombocytopenia presenting as intracerebral bleeding in utero. Indian J Pediatr 72 (2005) 269
31. Sharif U., and Kuban K. Prenatal intracranial hemorrhage and neurologic complications in alloimmune thrombocytopenia. J Child Neurol 16 (2001) 838-842
32. te Pas A.B., Lopriore E., van den Akker E.S., et al. Postnatal management of fetal and neonatal alloimmune thrombocytopenia: the role of matched platelet transfusion and IVIG. Eur J Pediatr 166 (2007) 1057-1063
33. Ward M.J., Pauliny J., Lipper E.G., and Bussel J.B. Long-term effects of fetal and neonatal alloimmune thrombocytopenia and its antenatal treatment on the medical and developmental outcomes of affected children. Am J Perinatol 23 (2006) 487-492
34. van den Akker E.S., and Oepkes D. Fetal and neonatal alloimmune thrombocytopenia. Best Pract Res Clin Obstet Gynaecol 22 (2008) 3-14
35. Murphy M.F., and Bussel J.B. Advances in the management of alloimmune thrombocytopenia. Br J Haematol 136 (2007) 366-378
36. Overton T.G., Duncan K.R., Jolly M., Letsky E., and Fisk N.M. Serial aggressive platelet transfusion for fetal alloimmune thrombocytopenia: platelet dynamics and perinatal outcome. Am J Obstet Gynecol 186 (2002) 826-831
37. Berkowitz R.L., Kolb E.A., McFarland J.G., et al. Parallel randomized trials of risk-based therapy for fetal alloimmune thrombocytopenia. Obstet Gynecol 107 (2006) 91-96
38. van den Akker E.S., Oepkes D., Lopriore E., Brand A., and Kanhai H.H. Noninvasive antenatal management of fetal and neonatal alloimmune thrombocytopenia: safe and effective. Br J Obstet Gynaecol 114 (2007) 469-473
39. Bassler D., Greinacher A., Okascharoen C., et al. A systematic review and survey of the management of unexpected neonatal alloimmune thrombocytopenia. Transfusion 48 (2008) 92-98
40. Allen D., Verjee S., Rees S., Murphy M.F., and Roberts D.J. Platelet transfusion in neonatal alloimmune thrombocytopenia. Blood 109 (2007) 388-389
41. Kiefel V., Bassler D., Kroll H., et al. Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT). Blood 107 (2006) 3761-3763
42. Kelton J.G. Idiopathic thrombocytopenic purpura complicating pregnancy. Blood Rev 16 (2002) 43-46
43. Bussel J.B. Immune thrombocytopenia in pregnancy: autoimmune and alloimmune. J Reprod Immunol 37 (1997) 35-61
44. Gill K.K., and Kelton J.G. Management of idiopathic thrombocytopenic purpura in pregnancy. Semin Hematol 37 (2000) 275-289
45. Alter B.P. Diagnosis, genetics, and management of inherited bone marrow failure syndromes. Hematol Am Soc Hematol Educ Prog (2007) 29-39
46. Andrew M., Vegh P., and Caco C. A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants. J Pediatr 123 (1993) 285-291
47. British Committee for Standard in Haematology, Available online at: http://www.bcshguidelines.com.