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For recent examples of the selective addition of indoles to in situ generated ketene iminium species from ynamides, see: a Y. Zhang, R. P. Hsung, X. Zhang, J. Huang, B. W. Slafer, A. Davis, Org. Lett. 2005, 7, 1047;
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25
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53549089037
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When 3-methylindole was employed as a coupling partner, an N-indoylamidine species was obtained in 20% yield under the present conditions..
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When 3-methylindole was employed as a coupling partner, an N-indoylamidine species was obtained in 20% yield under the present conditions..
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26
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53549131130
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For details, see the Supporting Information
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For details, see the Supporting Information.
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27
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53549098355
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For details of X-ray crystallographic data, see the Supporting Information
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For details of X-ray crystallographic data, see the Supporting Information.
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Recently, Carretero and co-workers reported a selective Cu-catalyzed aza Friedel-Crafts reaction of N-(2-pyridyl)sulfonyl aldimines with indoles and N-methylpyrrole; J. Esquivias, R. G. Arrayas, J. C. Carretero, Angew. Chem. 2006, 118, 645;
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