Design of a modular bioreactor to incorporate both perfusion flow and hydrostatic compression for tissue engineering applications

Annals of Biomedical Engineering

Volumn 36, Issue 7, 2008, Pages 1228-1241

  Orr, David E ^a   Burg, Karen J L ^a  

^a South   (United States)

Author keywords

Bone; Continuous scaffold; Discrete scaffold; Hydrostatic compression; Shear stress; Three dimensional

Indexed keywords

FLOW OF FLUIDS; HYDROSTATIC PRESSURE; SCAFFOLDS; SHEAR STRESS;

CONTINUOUS SCAFFOLDS; DISCRETE SCAFFOLDS; HYDROSTATIC COMPRESSION;

BONE;

ANIMAL; ARTICLE; BIOREACTOR; CELL PROLIFERATION; CELL STRAIN 3T3; CELL SURVIVAL; COMPRESSIVE STRENGTH; COMPUTER AIDED DESIGN; CULTURE TECHNIQUE; INSTRUMENTATION; MECHANOTRANSDUCTION; METHODOLOGY; MICROFLUIDICS; MOUSE; PERFUSION; PHYSIOLOGY; TISSUE ENGINEERING;

3T3 CELLS; ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL SURVIVAL; COMPRESSIVE STRENGTH; COMPUTER-AIDED DESIGN; MECHANOTRANSDUCTION, CELLULAR; MICE; MICROFLUIDICS; PERFUSION; TISSUE ENGINEERING;

EID: 44649147774     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-008-9505-0     Document Type: Article

References (38)

1. Bancroft G. N., V. I. Sikavitsas, A. G. Mikos. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng. 9(3):549-554, 2003
2. Bancroft G. N., V. I. Sikavitsas, J. van den Dolder, T. L. Sheffield, C. G. Ambrose, J. A. Jansen, A. G. Mikos. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc. Natl. Acad. Sci. U. S. A. 99(20):12600-12605, 2002
3. Basmadjian D. Mass transfer: principles and applications. New York: CRC Press, 2004
4. Basso N., J. N. M. Heersche. Characteristics of in vitro osteoblastic cell loading models. Bone 30(2):347-351, 2002
5. Botchwey E. A., S. R. Pollack, E. M. Levine, C. T. Laurencin. Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. J. Biomed. Mater. Res. 55(2):242-253, 2001
6. Brown T. D. Techniques for mechanical stimulation of cells in vitro: a review. J. Biomech. 33(1):3-14, 2000
7. Burger E. H., J. Klein-Nulend. Mechanotransduction in bone-role of the lacuno-canalicular network. FASEB J. 13S:S101-12, 1999
8. Cartmell S. H., B. D. Porter, A. J. Garcia, R. E. Guldberg. Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro. Tissue Eng. 9(6):1197-1203, 2003
9. Dahir G. A., Q. Cui, P. Anderson, C. Simon, C. Joyner, J. T. Triffitt, G. Balian. Pluripotential mesenchymal cells repopulate bone marrow and retain osteogenic properties. Clinical Orthopaedics 379S:S134-145, 2000
10. Diduch D. R., M. R. Coe, C. Joyner, M. E. Owen, G. Balian. Two cell lines from bone marrow that differ in terms of collagen synthesis, osteogenic characteristics, and matrix mineralization. J. Bone Joint Surg. Am. 75(1):92-105, 1993
11. Ducommun P., P. Ruffieux, M. Furter, I. Marison, U. von Stockar. A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures. J. Biotechnol. 78(2):139-47, 2000
12. Ergun S. Fluid flow through packed columns. Chem. Eng. Prog. 48(2):89-94, 1952
13. Fournier R. L. Basic transport phenomena in biomedical engineering. Philadelphia: Taylor & Francis, 1999
14. Gramer M. J., D. M. Poeschl. Screening tool for hollow-fiber bioreactor process development. Biotechnol. Prog. 14(2):203-209, 1998
15. Halberstadt C., C. Austin, J. Rowley, C. Culberson, A. Loebsack, S. Wyatt, S. Coleman, L. Blacksten, K. Burg, D. Mooney, W. Holder Jr. A hydrogel material for plastic and reconstructive applications injected into the subcutaneous space of a sheep. Tissue Eng. 8(2):309-319, 2002
16. Ingram M., G. B. Techy, R. Saroufeem, O. Yazan, K. S. Narayan, T. J. Goodwin, G. F. Spaulding. Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor. In vitro Cell. Dev. Biol. Anim. 33(6):459-466, 1997
17. Klein-Nulend J., A. Vanderplas, C. M. Semeins, N. E. Ajubi, J. A. Frangos, P. J. Nijweide, E. H. Burger. Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J. 9(5):441-445, 1995
18. McGlohorn J. B., L. W. Grimes, S. S. Webster, K. J. Burg. Characterization of cellular carriers for use in injectable tissue-engineering composites. J Biomed Mater Res A 66(3):441-9, 2003
19. Nagatomi J., B. P. Arulanandam, D. W. Metzger, A. Meunier, R. Bizios. Frequency- and duration-dependent effects of cyclic pressure on select bone cell functions. Tissue Eng. 7(6):717-728, 2001
20. Nagatomi J., B. P. Arulanandam, D. W. Metzger, A. Meunier, R. Bizios. Cyclic pressure affects osteoblast functions pertinent to osteogenesis. Ann. Biomed. Eng. 31(8):917-923, 2003
21. Nauman E. A., K. J. Risic, T. M. Keaveny, R. L. Satcher. Quantitative assessment of steady and pulsatile flow fields in a parallel plate flow chamber. Ann. Biomed. Eng. 27(2):194-199, 1999
22. Nauman E. A., R. L. Satcher, T. M. Keaveny, B. P. Halloran, D. D. Bikle. Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization. J. Appl. Physiol. 90(5):1849-1854, 2001
23. Nilsson J., A. Thorstensson. Adaptability in frequency and amplitude of leg movements during human locomotion at different speeds. Acta Physiol. Scand. 129(1):107-14, 1987
24. Obradovic B., R. L. Carrier, G. Vunjak-Novakovic, L. E. Freed. Gas exchange is essential for bioreactor cultivation of tissue engineered cartilage. Biotechnol. Bioeng. 63(2):197-205, 1999
25. Pazzano D., K. A. Mercier, J. M. Moran, S. S. Fong, D. D. DiBiasio, J. X. Rulfs, S. S. Kohles, L. J. Bonassar. Comparison of chondrogenesis in static and perfused bioreactor culture. Biotechnol. Prog. 16(5):893-896, 2000
26. Qiu Q. Q., P. Ducheyne, P. S. Ayyaswamy. 3D bone tissue engineered with bioactive microspheres in simulated microgravity. In vitro Cell. Dev. Biol. Anim. 37(3):157-165, 2001
27. Roelofsen J., J. Klein-Nulend, E. H. Burger. Mechanical stimulation by intermittent hydrostatic compression promotes bone-specific gene expression in vitro. J. Biomech. 28(12):1493-1503, 1995
28. Rubin C. T., K. J. McLeod, S. D. Bain. Functional strains and cortical bone adaptation: epigenetic assurance of skeletal integrity. J. Biomech. 23(Suppl 1):43-54, 1990
29. Schakenraad J. M., H. J. Busscher, C. R. Wildevuur, J. Arends. The influence of substratum surface free energy on growth and spreading of human fibroblasts in the presence and absence of serum proteins. J. Biomed. Mater. Res. 20(6):773-84, 1986
30. Scheidegger A. E. The physics of flow through porous media. Toronto: University of Toronto Press, 1974
31. Sherwood T. K., R. L. Pigford, C. R. Wilke. Mass transfer. New York: McGraw-Hill, 1975
32. Sikavitsas V. I., G. N. Bancroft, H. L. Holtorf, J. A. Jansen, A. G. Mikos. Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces. Proc. Natl. Acad. Sci. U. S. A. 100(25):14683-14688, 2003
33. Sodian R., T. Lemke, M. Loebe, S. P. Hoerstrup, E. V. Potapov, H. Hausmann, R. Meyer, R. Hetzer. New pulsatile bioreactor for fabrication of tissue-engineered patches. J. Biomed. Mater. Res. 58(4):401-405, 2001
34. Tanaka S. M., J. Li, R. L. Duncan, H. Yokota, D. B. Burr, C. H. Turner. Effects of broad frequency vibration on cultured osteoblasts. J. Biomech. 36(1):73-80, 2003
35. Wang L., S. P. Fritton, S. Weinbaum, S. C. Cowin. On bone adaptation due to venous stasis. J. Biomech. 36(10):1439-51, 2003
36. Weinbaum S., S. C. Cowin, Y. Zeng. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J. Biomech. 27(3):339-360, 1994
37. Zhang D., S. Weinbaum, S. C. Cowin. Estimates of the peak pressures in bone pore water. J. Biomech. Eng. 120(6):697-703, 1998
38. Zhang D. J., S. Weinbaum, S. C. Cowin. On the calculation of bone pore water pressure due to mechanical loading. Int. J. Solids Struct. 35(34-35):4981-4997, 1998