Behavioral and in vitro evaluation of tetrodotoxin tolerability for therapeutic applications

Toxicon

Volumn 51, Issue 8, 2008, Pages 1530-1534

  Morales, Lidia ^a   Pérez García, Carmen ^a   Salas, Elisabet ^a   González Martín, Carmen ^a   Castillo, Carmen ^a   Polanco, Maria José ^a   Herradón, Gonzalo ^a   Alguacil, Luis Fernando ^a  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

Cytotoxicity; HepG2; Place conditioning; Tetrodotoxin

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DRUG VEHICLE; MORPHINE; TETRODOTOXIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL LEVEL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DILUTION; DRUG TOLERABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CELL LINE, TUMOR; CONDITIONING (PSYCHOLOGY); CYTOTOXINS; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; TETRODOTOXIN; VEHICLES;

RATTUS;

EID: 44649143816     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.04.001     Document Type: Article

References (10)

1. Guzmán A., de Henestrosa A.R., Marín A.P., Ho A., Borroto J.I., Carasa I., and Pritchard L. Evaluation of the genotoxic potential of the natural neurotoxin tetrodotoxin (TTX) in a battery of in vitro and in vivo genotoxicity assays. Mutat. Res. 634 (2007) 14-24
2. Hagen N.A., Fisher K.M., Lapointe B., du Souich P., Chary S., Moulin D., Sellers E., Ngoc A.H., and Canadian Tetrodotoxin Study Group. An open-label, multi-dose efficacy and safety study of intramuscular tetrodotoxin in patients with severe cancer-related pain. J. Pain Symptom Manage. 34 (2007) 171-182
3. Marcil J., Walczak J.-S., Guindon J., Ngoc A.H., Lu S., and Beaulieu P. Antinociceptive effects of tetrodotoxin (TTX) in rodents. Br. J. Anaesth. 96 (2006) 761-768
4. Morales L., Pérez-García C., Díez-Fernández C., Garrido E., Alonso E., Salas E., Somoza B., and Alguacil L.F. Effects of peripheral tetrodotoxin injections on hyperalgesia, inflammation and place conditioning. Methods Findings Exp. Clin. Pharmacol. 28 Suppl. 2 (2006) 115
5. Morales L., Pérez-García C., Herradón G., and Alguacil L.F. Place conditioning in a two- or three-conditioning compartment apparatus: a comparative study with morphine and U-50,488. Addict. Biol. 12 (2007) 482-484
6. Mosher H.S., Fuhrman F.A., Buchwald H.D., and Fischer H.G. Tarichatoxin-tetrodotoxin: a potent neurotoxin. Science 144 (1964) 1100-1110
7. + channels. Jpn. J. Pharmacol. 88 (2002) 365-377
8. Padera R.F., Tse J.Y., Bellas E., and Kohane D.S. Tetrodotoxin for prolonged local anesthesia with minimal myotoxicity. Muscle Nerve 34 (2006) 747-753
9. Pinti M., Troiano L., Nasi M., Ferraresi R., Dobrucki J., and Cossarizza A. Hepatoma HepG2 cells as a model for in vitro studies on mitochondrial toxicity of antiviral drugs: which correlation with the patient? J. Biol. Regul. Homeostatic Agents 17 (2003) 166-171
10. Xu Q., Huang K., Gao L., Zhang H., and Rong K. Toxicity of tetrodotoxin towards mice and rabbits. Wei Sheng Yan Jiu 32 (2003) 371-374