Echinacea purpurea diminishes neovascular reaction induced in mice skin by human cancer cells and stimulates non-specific cellular immunity in humans

Central-European Journal of Immunology

Volumn 33, Issue 3, 2008, Pages 127-130

  Rogala, Ewa ^a   Skopińska Rózewska, Ewa ^b   Wasiutyński, Aleksander ^b   Siwicki, Andrzej K ^c   Sommer, Ewa ^b   Pastewka, Krzysztof ^d  

^a NATIONAL TUBERCULOSIS AND LUNG DISEASES RESEARCH INSTITUTE   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

^d Medical Center of Postgraduate Education   (Poland)

Author keywords

Angiogenesis; Echinacea purpurea; Granulocytes; Human cancers; NK cells

Indexed keywords

CD16 ANTIGEN; CD56 ANTIGEN; ECHINACEA PURPUREA EXTRACT; IMMUNAL FORTE; PLACEBO;

ADULT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL REACTIVITY; CANCER CELL; CELLULAR IMMUNITY; CHEMOLUMINESCENCE; CLINICAL ARTICLE; ECHINACEA PURPUREA; FEMALE; GRANULOCYTE; HUMAN; HUMAN TISSUE; IMMUNOSTIMULATION; MOUSE; NATURAL KILLER T CELL; NONHUMAN; NORMAL HUMAN; STATISTICAL SIGNIFICANCE; STUDENT T TEST; TREATMENT DURATION; VOLUNTEER;

EID: 44649136996     PISSN: 14263912     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Skopińska-Różewska E, Wojtasik E: Immunotropowe działanie jeżówek. In: Skopińska-Różewska E (ed.). Wpływ substancji naturalnych na układ odpornościowy. Wyd. Fundacja Pomocy Zdrowiu, Warszawa 2002; 32-42.
2. Facino RM, Carini M, Aldini G et al. (1995): Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage. Planta Med 61: 510-514.
3. Clifford LJ, Nair MG, Rana J, Dewitt DL (2002): Bioactivity of alkamides isolated from Echinacea purpurea (L) Moench. Phytomedicine 9: 249-253.
4. Hayashi I, Ohotsuki M, Suzuki I, Watanabe T (2001): Effects of oral administration of Echinacea purpurea (American herb) on incidence of spontaneous leukemia caused by recombinant leukemia viruses in AKR/J mice. Nihon Rinsho Meneki Gakkai Kaishi 20: 10-20.
5. Chicca A, Adinolfi B, Martinotti E et al. (2007): Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines. J. Ethnopharmacol 110: 148-153.
6. Melchart D, Clemm C, Weber B et al. (2002): Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract undesired effects of chemotherapy-a pilot study. Phytother Res 16: 138-142.
7. Bany J, Skopińska-Różewska E, Chorostowska-Wynimko J et al. (2004): The effect of complex herbal remedy on the angiogenic activity of L-1 sarcoma cells, L-1 sarcoma tumor growth and on the bacterial infection in mice. Centr Eur J Immunol 29: 1-6.
8. Skopinska-Rózewska E, Krotkiewski M, Sommer E et al. (1999): Inhibitory effect of shark liver oil on cutaneous angiogenesis induced in Balb/c mice by syngenic sarcoma L-1, human urinary bladder and human kidney tumor cells. Oncol Rep 6: 1341-1344.
9. Skopińska-Różewska E, Strzelecka H, Sommer E et al. (2001): Immunotropic and antiangiogenic properties of EKOGAL. Onkologia Polska 4/3(4): 121-124.
10. Skopińska-Różewska E, Sokolnicka I, Radomska-Leśniewska D et al. (2003): The in vivo effect of Echinacea purpurea succus on various functions of human blood leukocytes. Centr Eur J Immunol 28: 126-130.
11. Sidky YA, Auerbach R (1975): Lymphocyte induced angiogenesis: A quantitive and sensitive assay of graft-versus host reaction. J Exp Med 141: 1084-1092.
12. Skopińska-Różewska E, Sommer E, Demkow U et al. (1997): Screening of angiogenesis inhibitors by modified tumor induced angiogenesis (TIA) test in lung cancer. Rocz Acad Med Bialymst 42: 287-296.
13. Kim MH (2003): Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. J Cell Biochem 89: 529-538.
14. Lamy S, Gingras D, Béliveau R (2002): Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res 15: 381-385.
15. Razina TG, Lopatina KA, Zueva AM et al. (2007): Effect of Echinacea purpurea tincture and its polysaccharide complex on the efficacy of cytostatic therapy of transferred tumors. Eksp Klin Farmakol 70: 33-35.
16. Roesler J, Steinmüller C, Kiderlen A et al. (1991): Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to mice mediates protection against systemic infections with Listeria monocytogenes and Candida albicans. Int J Immunopharmacol 13: 27-37.
17. Currier NL, Miller SC (2000): Natural killer cells from aging mice treated with extracts from Echinacea purpurea are quantitatively and functionally rejuvenated. Exp Gerontol 35: 627-639.
18. Sun LZ, Currier NL, Miller SC (1999): The American cone-flower: a prophylactic role involving nonspecific immunity. J Altern Complement Med 5: 437-446.
19. Currier NL, Miller SC (2001): Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life span. J Altern Complement Med 7: 241-251.