Small-fibre involvement in diabetic patients with neuropathic foot pain

Diabetic Medicine

Volumn 25, Issue 6, 2008, Pages 692-699

  Vlckova Moravcova, E ^a   Bednarik, J ^a   Belobradkova, J ^a   Sommer, C ^b  

^a UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Diabetic neuropathy; Pain; Skin biopsy; Small fibre; Thermal threshold

Indexed keywords

ADULT; AGED; ARTICLE; AUTONOMIC DYSFUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; FEMALE; FOOT PAIN; HUMAN; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; MALE; NERVE CONDUCTION; NERVE FIBER; NERVE FUNCTION; NEUROPATHIC PAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL NERVE; PUNCH BIOPSY; SKIN NERVE;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; DIABETIC FOOT; EVOKED POTENTIALS, SOMATOSENSORY; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; NEURONS, AFFERENT; PAIN; SENSATION DISORDERS; SENSORY THRESHOLDS; SKIN;

EID: 44649124932     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2008.02446.x     Document Type: Article

References (28)

1. Nash TP. Treatment options in painful diabetic neuropathy. Acta Neurol Scand 1999 173 : 36 42.
2. Schmader KE. Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy. Clin J Pain 2002 18 : 350 354.
3. Daousi C, MacFarlane IA, Woodward A, Nurmikko TJ, Bundred PE, Benbow SJ. Chronic painful peripheral neuropathy in an urban community: a controlled comparison of people with and without diabetes. Diabet Med 2004 21 : 976 982.
4. Kramer HH, Rolke R, Bickel A, Birklein F. Thermal thresholds predict painfulness of diabetic neuropathies. Diabetes Care 2004 27 : 2386 2391.
5. Polydefkis M, Yiannoutsos CT, Cohen BA, Hollander H, Schifitto G, Clifford DB et al. Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 2002 58 : 115 119.
6. Stewart JD, Low PA, Fealey RD. Distal small fiber neuropathy: results of tests of sweating and autonomic cardiovascular reflexes. Muscle Nerve 1992 15 : 661 665.
7. Lacomis D. Small-fiber neuropathy. Muscle Nerve 2002 26 : 173 188.
8. Llewelyn JG, Gilbey SG, Thomas PK, King RH, Muddle JR, Watkins PJ. Sural nerve morphometry in diabetic autonomic and painful sensory neuropathy. A clinicopathological study. Brain 1991 114 : 867 892.
9. Malik RA, Veves A, Walker D, Siddique I, Lye RH, Schady W et al. Sural nerve fibre pathology in diabetic patients with mild neuropathy: relationship to pain, quantitative sensory testing and peripheral nerve electrophysiology. Acta Neuropathol (Berl) 2001 101 : 367 374.
10. Valk GD, Grootenhuis PA, van Eijk JT, Bouter LM, Bertelsmann FW. Methods for assessing diabetic polyneuropathy: validity and reproducibility of the measurement of sensory symptom severity and nerve function tests. Diabetes Res Clin Pract 2000 47 : 87 95.
11. Orstavik K, Namer B, Schmidt R, Schmelz M, Hilliges M, Weidner C et al. Abnormal function of C-fibers in patients with diabetic neuropathy. J Neurosci 2006 26 : 11287 11294.
12. World Health Organisation. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. 1999 WHO/NCD/NDS/99.2.
13. Vlckova-Moravcova E, Bednarik J, Dusek L, Toyka K, Sommer C. Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Muscle Nerve 2008 37 : 50 60.
14. Moravcova E, Bednarik J. [Computer-assisted thermal threshold testing - normative data and sources of variability]. Cesk Slov Neurol N 2003 66/99 : 263 269.
15. Proceedings of a consensus development conference on standardized measures in diabetic neuropathy. Electrodiagnostic measures. Muscle Nerve 1992 15 : 1150 1154.
16. Kadanka Z, Bednarik J, Vohanka S. [Practical Electromyography], 1st edn. Brno : IDPVZ, 1994.
17. Moravcova E, Bednarik J, Feit J, Sommer C. [The evaluation of intraepidermal nerve fiber density in skin biopsy of polyneuropathy patients]. Cesk Slov Neurol N 2005 68/101 : 219 226.
18. Lauria G, Cornblath DR, Johansson O, McArthur JC, Mellgren SI, Nolano M et al. EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol 2005 12 : 747 758.
19. Kennedy WR, Wendelschafer-Crabb G, Polydefkis M, McArthur JC. Pathology and quantitation of cutaneous innervation. In Dyck PJ, Thomas PK eds. Peripheral Neuropathy. Philadelphia : Elsevier, 2005 : 869 895.
20. Kennedy WR, Wendelschafer-Crabb G, Johnson T. Quantification of epidermal nerves in diabetic neuropathy. Neurology 1996 47 : 1042 1048.
21. Polydefkis M, Hauer P, Sheth S, Sirdofsky M, Griffin JW, McArthur JC. The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain 2004 127 : 1606 1615.
22. Shun CT, Chang YC, Wu HP, Hsieh SC, Lin WM, Lin YH et al. Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments. Brain 2004 127 : 1593 1605.
23. Lauria G, Morbin M, Lombardi R, Borgna M, Mazzoleni G, Sghirlanzoni A et al. Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies. Neurology 2003 61 : 631 636.
24. Sorensen L, Molyneaux L, Yue DK. The relation among pain, sensory loss and small nerve fibers in diabetes. Diabetes Care 2006 29 : 883 887.
25. Sorensen L, Molyneaux L, Yue DK. Insensate versus painful diabetic neuropathy: the effects of height, gender, ethnicity and glycaemic control. Diabetes Res Clin Pract 2002 57 : 45 51.
26. Umapathi T, Tan WL, Loke SC, Soon PC, Tavintharan S, Chan YH. Intraepidermal nerve fiber density as a marker of early diabetic neuropathy. Muscle Nerve 2007 35 : 591 598.
27. Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology 2003 60 : 108 111.
28. Neuromuscular Homepage of the Washington University, St. Louis, MO, USA. Available at: http://www.neuro.wustl.edu/neuromuscular/nother/diabetes.htm.