Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144: I. Taxonomy, fermentation, isolation and structural elucidation

Journal of Antibiotics

Volumn 61, Issue 1, 2008, Pages 1-6

  Fukumoto, Atsushi ^a   Kim, Yong Pil ^b   Matsumoto, Atsuko ^b   Takahashi, Yoko ^a   Shiomi, Kazuro ^a   Tomoda, Hiroshi ^a,b   Omura, Satoshi ^a,b  

^a KITASATO UNIVERSITY   (Japan)

^b KITASATO INSTITUTE   (Japan)

Author keywords

Cyslabdan; Imipenem potentiator; Methicillin resistant Staphylococcus aureus; MRSA; Structural elucidation

Indexed keywords

ACETYLCYSTEINE; AMINO ACID; ANTIBIOTIC AGENT; BACTERIAL ENZYME; CYSLABDAN; DITERPENE; IMIPENEM; METICILLIN; SULFIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; DRUG DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; COLUMN CHROMATOGRAPHY; DRUG STRUCTURE; ENZYME ISOLATION; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES; TAXONOMY; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; CONFORMATION; DRUG EFFECT; DRUG POTENTIATION; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PENICILLIN RESISTANCE; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS AUREUS; ULTRASTRUCTURE;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STREPTOMYCES SP.;

ACETYLCYSTEINE; ANTI-BACTERIAL AGENTS; DITERPENES; DRUG SYNERGISM; FERMENTATION; HUMANS; IMIPENEM; MAGNETIC RESONANCE SPECTROSCOPY; METHICILLIN RESISTANCE; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS; STREPTOMYCES;

EID: 44649111844     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.101     Document Type: Article

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