Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3565-3569

  Tipparaju, Suresh K ^a   Joyasawal, Sipak ^a   Forrester, Sara ^a   Mulhearn, Debbie C ^a   Pegan, Scott ^a   Johnson, Michael E ^a   Mesecar, Andrew D ^a   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Anthrax

Indexed keywords

2 PYRIDONE DERIVATIVE; CHLORINE; DIPYRONE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); FATTY ACID; HYDROGEN; TRICLOSAN;

ALKYLATION; ARTICLE; ATMOSPHERIC PRESSURE; BACILLUS ANTHRACIS; BACTERIAL GENE; CATALYSIS; DEBENZYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; FAB1 GENE; FATTY ACID SYNTHESIS; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PYRIDONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS);

EID: 44649109512     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.004     Document Type: Article

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