Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action

Regulatory Toxicology and Pharmacology

Volumn 51, Issue 2 SUPLL, 2008, Pages 27-36

  Bogen, Kenneth T ^a   Benson, Janet M ^b   Yost, Garold S ^c   Morris, John B ^d   Dahl, Alan R ^e   Clewell III, Harvey J ^f   Krishnan, Kannan ^g   Omiecinski, Curtis J ^h  

^a EXPONENT INC   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^g UNIVERSITÉ DE MONTRÉAL   (Canada)

^h PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

1,2 Epoxide; 1,2 Naphthoquinone; 1,4 Naphthoquinone; Age dependent differences; Cancer; Carcinogenicity; Cytochrome P450; Cytotoxicity; Gender differences; Glutathione depletion; Inflammation; Mechanism of action; Metabolism; Mode of action; Naphthalene; Olfactory epithelial neuroblastoma; PBPK modeling; Respiratory epithelial adenoma; Species differences; Tumorigenesis

Indexed keywords

NAPHTHALENE;

ARTICLE; CARCINOGENESIS; CYTOTOXICITY; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; IN VIVO STUDY; LUNG TUMOR; NONHUMAN; PRIORITY JOURNAL;

PRIMATES; RATTUS; RODENTIA;

EID: 44649105656     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2007.10.018     Document Type: Article

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