In vivo determination of the time and location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract

Magnetic Resonance Imaging

Volumn 26, Issue 5, 2008, Pages 638-643

  Kremser, Christian ^a   Albrecht, Karin ^b   Greindl, Melanie ^b   Wolf, Christian ^a   Debbage, Paul ^a   Bernkop Schnürch, Andreas ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Gastrointestinal tract; Gd DTPA; Magnetic resonance imaging; Mucoadhesive polymers

Indexed keywords

ADHESIVE AGENT; GADOLINIUM PENTETATE; POLYMER; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRY POWDER; GASTROINTESTINAL TRACT; IN VIVO STUDY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SMALL INTESTINE; STATISTICAL SIGNIFICANCE;

ACRYLIC RESINS; ADMINISTRATION, ORAL; ANIMALS; ARTIFACTS; CONTRAST MEDIA; DRUG DELIVERY SYSTEMS; FLUORESCEIN; GADOLINIUM DTPA; INTESTINAL MUCOSA; MAGNETIC RESONANCE IMAGING; MALE; PHANTOMS, IMAGING; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 44649105614     PISSN: 0730725X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mri.2008.01.004     Document Type: Article

References (29)

1. Jasti B. Recent advances in mucoadhesive drug delivery systems. Business Briefing: Pharmatech (2003) 194-196
2. Harris D., Fell J.T., Sharma H.L., and Taylor D.C. GI transit of potential bioadhesive formulations in man: a scintigraphic study. J Control Release 12 1 (1990) 45-53
3. Chopra S., Mahdi S., Kaur J., Iqbal Z., Talegaonkar S., and Ahmad F.J. Advances and potential applications of chitosan derivatives as mucoadhesive biomaterials in modern drug delivery. J Pharm Pharmacol 58 8 (2006) 1021-1032
4. Singh B., Chakkal S.K., and Ahuja N. Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology. AAPS PharmSciTech 7 1 (2006) E3
5. Bardonnet P.L., Faivre V., Pugh W.J., Piffaretti J.C., and Falson F. Gastroretentive dosage forms: overview and special case of Helicobacter pylori. J. Control Release 111 1-2 (2006) 1-18
6. Streubel A., Siepmann J., and Bodmeier R. Gastroretentive drug delivery systems. Expert Opin Drug Deliv 3 2 (2006) 217-233
7. Talukder R., and Fassihi R. Gastroretentive delivery systems: a mini review. Drug Dev Ind Pharm 30 10 (2004) 1019-1028
8. Hirtz J. The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation. Br J Clin Pharmacol 19 Suppl 2 (1985) 77S-83S
9. 19F nuclear magnetic resonance. Magn Reson Med 48 2 (2002) 255-261
10. Hinton J.M., Lennard-Jones J.E., and Young A.C. A new method for studying gut transit times using radiopaque markers. Gut 10 10 (1969) 842-847
11. Camilleri M., Colemont L.J., Phillips S.F., Brown M.L., Thomforde G.M., Chapman N., et al. Human gastric emptying and colonic filling of solids characterized by a new method. Am J Physiol 257 2 Pt 1 (1989) G284-G290
12. Amend M., and Greiner L. The Sono-Capsule: a new method for measuring gastrointestinal motility. Ultraschall Med 17 6 (1996) 274-276
13. Ewe K., Press A.G., and Dederer W. Gastrointestinal transit of undigestible solids measured by metal detector EAS II. Eur J Clin Invest 19 3 (1989) 291-297
14. Weitschies W., Wedemeyer J., Stehr R., and Trahms L. Magnetic markers as a noninvasive tool to monitor gastrointestinal transit. IEEE Trans Biomed Eng 41 2 (1994) 192-195
15. Leng-Peschlow E. Effect of sennosides and related compounds on intestinal transit in the rat. Pharmacology 36 Suppl 1 (1988) 40-48
16. Richardson J.C., Bowtell R.W., Mader K., and Melia C.D. Pharmaceutical applications of magnetic resonance imaging (MRI). Adv Drug Deliv Rev 57 8 (2005) 1191-1209
17. Melia C.D., Rajabi-Siahboomi A.R., and Bowtell R.W. Magnetic resonance imaging of controlled release pharmaceutical dosage forms. Pharm Sci Technol Today 1 1 (1998) 32-39
18. Christmann V., Rosenberg J., Seega J., and Lehr C.M. Simultaneous in vivo visualization and localization of solid oral dosage forms in the rat gastrointestinal tract by magnetic resonance imaging (MRI). Pharm Res 14 8 (1997) 1066-1072
19. Steingoetter A., Kunz P., Weishaupt D., Mader K., Lengsfeld H., Thumshirn M., et al. Analysis of the meal-dependent intragastric performance of a gastric-retentive tablet assessed by magnetic resonance imaging. Aliment Pharmacol Ther 18 7 (2003) 713-720
20. Faas H., Schwizer W., Feinle C., Lengsfeld H., de Smidt C., Boesiger P., et al. Monitoring the intragastric distribution of a colloidal drug carrier model by magnetic resonance imaging460. Pharm Res 18 4 (2001) 460-466
21. Steingoetter A., Weishaupt D., Kunz P., Mäder K., Lengsfeld H., Thumshirn M., et al. Magnetic resonance imaging for the in vivo evaluation of gastric-retentive tablets. Pharm Res 20 12 (2003) 2001-2007
22. Albrecht K., Greindl M., Kremser C., Wolf C., Debbage P., and Bernkop-Schnurch A. Comparative in vivo mucoadhesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection. J Control Release 115 1 (2006) 78-84
23. Waynforth H., and Flecknell P. Experimental and surgical technique in the rat. 2nd ed. (1992), Academic Press, London
24. Bernkop-Schnurch A. Mucoadhesive polymers: strategies, achievements and future challenges. Adv Drug Deliv Rev 57 11 (2005) 1553-1555
25. Langoth N., Kalbe J., and Bernkop-Schnurch A. Development of a mucoadhesive and permeation enhancing buccal delivery system for PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide). Int J Pharm 296 1-2 (2005) 103-111
26. Kaminsky S., Laniado M., Gogoll M., Kornmesser W., Clauss W., Langer M., et al. Gadopentetate dimeglumine as a bowel contrast agent: safety and efficacy. Radiology 178 2 (1991) 503-508
27. Schneider G., Reimer P., Mamann A., Kirchin M.A., Morana G., and Grazioli L. Contrast agents in abdominal imaging: current and future directions. Top Magn Reson Imaging 16 1 (2005) 107-124
28. 19F-MRI of perfluorononane as a novel contrast modality for gastrointestinal imaging. Magn Reson Med 41 1 (1999) 80-86
29. Lecomte F., Siepmann J., Walther M., MacRae R.J., and Bodmeier R. pH-sensitive polymer blends used as coating materials to control drug release from spherical beads: elucidation of the underlying mass transport mechanisms. Pharm Res 22 7 (2005) 1129-1141