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Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3597-3602

C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I

(6) Wang, Yifan a Ng, Magdeline Tao Tao a Zhou, Tianyan c Li, Xinming a Tan, Choon Hong a Li, Tianhu a,b

a NATIONAL UNIVERSITY OF SINGAPORE (Singapore)

b NANYANG TECHNOLOGICAL UNIVERSITY (Singapore)

c PEKING UNIVERSITY HEALTH SCIENCE CENTER (China)

Author keywords

Circular oligonucleotide; Enzyme inhibitor; Human topoisomerase I

Indexed keywords

DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; OLIGONUCLEOTIDE; OLIGONUCLEOTIDE 1; OLIGONUCLEOTIDE 4; OLIGONUCLEOTIDE 5; OLIGONUCLEOTIDE 6; OLIGONUCLEOTIDE 7; SPACER DNA;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; MISMATCH REPAIR; SYNTHESIS;

BASE SEQUENCE; BINDING SITES; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44649092612 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2008.04.076 Document Type: Article

Times cited : (8)

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