Optimising nasal spray parameters for efficient drug delivery using computational fluid dynamics

Computers in Biology and Medicine

Volumn 38, Issue 6, 2008, Pages 713-726

  Inthavong, K ^a   Tian, Z F ^a   Tu, J Y ^a   Yang, W ^b   Xue, C ^a  

^a RMIT UNIVERSITY   (Australia)

^b CSIRO   (Australia)

Author keywords

CFD; Drug delivery; Nasal cavity; Nasal spray; Numerical simulation; Particle deposition

Indexed keywords

BOUNDARY CONDITIONS; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; PARAMETER ESTIMATION; SPRAYING; VELOCITY MEASUREMENT;

NASAL CAVITY; NASAL SPRAY; PARTICLE DEPOSITION; PARTICLE IMAGE VELOCIMETRY;

DRUG DELIVERY;

NOSE SPRAY;

ARTICLE; BREATHING RATE; COMPUTATIONAL FLUID DYNAMICS; DRUG DELIVERY SYSTEM; IMAGING; NOSE CAVITY; PARTICLE SIZE; PRIORITY JOURNAL; QUALITATIVE RESEARCH; SIMULATION;

ADMINISTRATION, INTRANASAL; AEROSOLS; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; NASAL CAVITY; PARTICLE SIZE; SOFTWARE;

EID: 44549088900     PISSN: 00104825     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compbiomed.2008.03.008     Document Type: Article

References (32)

1. Kimbell J., Shroeter J.D., Asgharian B., Wong B.A., Segal R.A., Dickens C.J., et al. Optimisation of nasal delivery devices using computational models. Res. Drug Del. 9 (2004) 233-238
2. Inthavong K., Tian Z.F., Li H.F., Tu J.Y., Yang W., Xue C.L., et al. A numerical study of spray particle deposition in a human nasal cavity. Aerosol Sci. Technol. 40 (2006) 1034-1045
3. Kelly J.T., Asgharian B., Kimbell J.S., and Wong B.A. Particle deposition in human nasal airway replicas manufactured by different methods. Part 1: inertial regime particles. Aerosol Sci. Tech. 38 (2004) 1063-1071
4. Zwartz G.J., and Guilmette R.A. Effect of flow rate on particle deposition in a replica of a human nasal airway. Inhal. Toxic. 13 (2001) 109-127
5. Gao J., Jiang D., Huang Z., and Wane X. Experimental and numerical study of high-pressure-swirl injector sprays in a direct injection gasoline engine. Proc. Inst. Mech. Eng. A J. Power Energy 219 8 (2005) 617-629
6. Straatsma J., Van Houwelingen G., Steenbergen A.E., and De Jong P. Spray drying of food products: 1. Simulation model. J. Food Eng. 42 2 (1999) 67-72
7. Kesavanathan J., Bascom R., and Swift D.L. The effect of nasal passage characteristics on particle deposition. J. Aerosol. Med. 11 (1998) 27-39
8. Newman S.P., Moren F., and Clarke S.W. Deposition pattern of nasal sprays in man. Rhinology 26 (1998) 111-120
9. Swift D.L. Inspiratory inertial deposition of aerosols in human nasal airway replicate casts: implication for the proposed NCRP lung model. Radiat. Prot. Dosim. 38 (1991) 29-34
10. Cheng Y.S., Holmes T.D., Gao J., Guilmette R.A., Li S., Surakitbanharn Y., et al. Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway. J. Aerosol. Med. 14 2 (2001) 267-280
11. Suman J.D., Laube B.L., Lin T.C., Brouet G., and Dalby R. Validity of in vitro tests on aqueous spray pumps as surrogates for nasal deposition. Pharma. Res. 19 (2002) 1-6
12. Hörschler I., Meinke M., and Schröder W. Numerical simulation of the flow field in a model of the nasal cavity. Comp. Fluids 32 (2003) 39-45
13. J.Y. Tu, B. Abu-Hijleh, C. Xue, C.G. Li, CFD simulation of air/particle flow in the human nasal cavity, in: Proceedings of 5th International Conference on Multiphase Flow, Yokohama, Japan, 2004.
14. Zamankhan P., Ahmadi G., Wang Z., Hopke P.H., Cheng Y.S., Su W.C., et al. Airflow and deposition of nanoparticles in a human nasal cavity. Aerosol Sci. Technol. 40 (2006) 463-476
15. Zhang Y., Finlay W.H., and Matida E.A. Particle deposition measurements and numerical simulation in a highly idealized mouth-throat. J. Aerosol Sci. 35 (2004) 789-803
16. Isabey D., and Chang H.K. Steady and unsteady pressure-flow relationships in central airways. J. Appl. Physiol. 51 (1981) 1338-1348
17. Shi H., Kleinstreuer C., and Zhang Z. Laminar airflow and nanoparticle or vapor deposition in a human nasal cavity model. J. Biomech. Eng. 128 (2006) 697-706
18. Schreck S., Sullivan K.J., Ho C.M., and Chang H.K. Correlations between flow resistance and geometry in a model of the human nose. J. Appl. Physiol. 75 4 (1993) 1767-1775
19. Keyhani K., Scherer P.W., and Mozell M.M. Numerical simulation of airflow in the human nasal cavity. J. Biomech. Eng. 117 (1995) 429-441
20. Corey J.P., Gungor A., Nelson R., Fredberg J., and Lai V. A comparison of the nasal cross-sectional areas and volumes obtained with acoustic rhinometry and magnetic resonance imaging. Otolaryngol. Head Neck Surg. 117 4 (1997) 349-354
21. Hilberg O., Jensen F.T., and Pedersen O.F. Nasal airway geometry: comparison between acoustic reflections and magnetic resonance scanning. J. Appl. Physiol. 75 (1993) 2811-2819
22. Swift D.L., and Proctor D.F. Access of air to the respiratory tract. In: Brain J.D., Proctor D.F., and Reid L.M. (Eds). Respiratory Defence Mechanisms (1977), Marcel Dekker, New York, NY 63-93
23. Hahn I., Scherer P.W., and Mozell M.M. Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. J. Appl. Physiol. 75 5 (1993) 2273-2287
24. M.H.D. Finck, I. Wlokas, Simulation of nasal flow by lattice Boltzmann methods, Comp. Biol. Med. 2006. doi:10.1016/j.compbiomed.2006.06.013.
25. Subramaniam R.P., Richardson R.B., Morgan K.T., Kimbell J.S., and Guilmette R.A. Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal. Toxicol. 10 (1998) 91-120
26. Chang H.K. Flow dynamics in the respiratory tract. In: Chang H.K., and Paiva M. (Eds). Respiratory Physiology, an Analytical Approach (1989), Dekker, New York 54-138
27. Sullivan K.J., and Chang H.K. Steady and oscillatory trans-nasal pressure-flow relationships in healthy adults. J. Appl. Physiol. 71 (1991) 983-992
28. Crowe C.T., Sommerfeld M., and Tsuji Y. Multiphase Flows with Droplets and Particles (1998), CRC Press, Boca Raton, FL
29. Lefebvre A.H. Atomization and Sprays (1989), Hemisphere Publishing Corporation
30. K.R. Babu, M.V. Narasimhan, K. Narayanaswamy, Correlations for prediction of discharge rate, cone angle and aircore diameter of swirl spray atomisers, in: Proceedings of the 2nd International Conference on Liquid Atomisation and Spray Systems, Madison, WI, 1982, pp. 91-97.
31. Rizk N.K., and Lefebvre A.H. Internal flow characteristics of simplex swirl atomisers. AIAA J. Propul. Power 1 3 (1985) 193-199
32. Häußermann S., Bailey A.G., Bailey M.R., Etherington G., and Youngman M.J. The influence of breathing patterns on particle deposition in a nasal replicate cast. J. Aerosol. Sci. 33 (2001) 923-933