Methylene blue improves hemodynamic shock but increases lipoperoxidation in severe acute pancreatitis pig model

Acta Cirurgica Brasileira

Volumn 23, Issue SUPPL., 2008, Pages 8-16

  Meirelles Jr , Roberto Ferreira ^a   Ceneviva, Reginaldo ^a   Viaro, Fernanda ^a   Baldo, Caroline Floreoto ^a   Evora, Paulo Roberto Barbosa ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute pancreatitis; Lipoperoxidation; Methylene blue; Nitric oxide; Shock; Taurocholate

Indexed keywords

AMYLASE; ENTEROPEPTIDASE; MALONALDEHYDE; METHYLENE BLUE; NITRATE; TAUROCHOLIC ACID;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; HEMODYNAMICS; LIPID PEROXIDATION; MALE; MICROCIRCULATION; NONHUMAN; SHOCK; SWAN GANZ CATHETER;

ACUTE DISEASE; ANIMALS; BIOLOGICAL MARKERS; CHOLAGOGUES AND CHOLERETICS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENTEROPEPTIDASE; ENZYME INHIBITORS; HEMODYNAMICS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; METHYLENE BLUE; NITRATES; PANCREATITIS; SHOCK, CARDIOGENIC; SWINE; TAUROCHOLIC ACID; TIME FACTORS;

EID: 44449178792     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502008000700003     Document Type: Article

References (46)

1. Sweiry JH, Mann GE. Role of oxidative stress in the pathogenesis of acute pancreatitis. Scand J Gastroenterol Supp.l 1996;219:10-5.
2. Tani S, Itoh H, Okabayashi Y, Nakamura T, Fujii M, Fujisawa T, Koide M, Otsuki M. New model of acute necrotizing pancreatitis induced by excessive doses of arginine in rats. Dig Dis Sci. 1990;35:367-74.
3. Dabrowski A, Gabryelewicz A. Nitric oxide contributes to multiorgan oxidative stress in acute experimental pancreatitis. Scand J Gastroenterol. 1994;29:943-8.
4. Gukovskaya A, Pandol S. Nitric oxide production regulates cGMP formation and calcium influx in pancreatic acinar cells. Am J Physiol. 1994;266:G350-6.
5. Holst JJ, Rasmussen TN, Schmidt P. Role of nitric oxide in neurally induced pancreatic exocrine secretion in pigs. Am J Physiol. 1994;266:G206-13.
6. Satoh A, Shimosegawa T, Abe T, Kikuchi Y, Abe R, Koizumi M, Toyota T. Role of nitric oxide in the pancreatic blood flow response to caerulein. Pancreas. 1994;9:574-9.
7. Patel AG, Toyama MT, Nguyen TN, Cohen GA, Ignarro LJ, Reber HA, Ashley SW. Role of nitric oxide in the relationship of pancreatic blood flow and exocrine secretion in cats. Gastroenterology. 1995;108:1215-20.
8. Holzmann S. Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips. J Cyclic Nucleotide Res. 1982;8:409-19.
9. Martin W, Villani GM, Jothianandan D, Furchgott RF. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J Pharmacol Exp Ther. 1985;232:708-16.
10. Aho HJ, Koskensalo SM, Nevalainen TJ. Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol. 1980;15:411-6.
11. Yekebas EF, Treede H, Knoefel WT, Bloechle C, Fink E, Izbicki JR. Influence of zero-balanced hemofiltration on the course of severe experimental pancreatitis in pigs. Ann Surg. 1999;229:514-2.
12. Antunes-Rodrigues J, McCann SM. Water, sodium chloride, and food intake induced by injections of cholinergic and adrenergic drugs into the third ventricle of the rat brain. Proc Soc Exp Biol Med. 1970;133:1464-70.
13. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302-10.
14. Wainwright M, Crossley KB. Methylene Blue - a therapeutic dye for all seasons? J Chemother. 2002;14:431-43.
15. Blass N, Fung D. Dyed but not dead - methylene blue overdose. Anesthesiology. 1976;45:458-9.
16. Simsek I, Mas MR, Yasar M, Ozyurt M, Saglamkaya U, Deveci S, Comert B, Basustaoglu A, Kocabalkan F, Refik M. Inhibition of inducible nitric oxide synthase reduces bacterial translocation in a rat model of acute pancreatitis. Pancreas. 2001;23:296-301.
17. Morikawa M, Inoue M, Tokumaru S, Kogo H. Enhancing and inhibitory effects of nitric oxide on superoxide anion generation in human polymorphonuclear leukocytes. Br J Pharmacol. 1995;115:1302-6.
18. Al-Mufti RA, Williamson RC, Mathie RT. Increased nitric oxide activity in a rat model of acute pancreatitis. Gut. 1998;43:564-70.
19. Steinberg SM, Gower WR Jr, Martin D, Carey LC, Cloutier CT. Experimental pancreatitis does not produce pulmonary hypertension. Surg Gynecol Obstet. 1983;157:530-3.
20. Rämä OJ, Rämö P, Karhunen M, Kiviniemi H, Kettunen R. Impaired venous return causes circulatory failure in experimental pancreatitic shock in dogs. Intensive Care Med. 1989;15:111-5.
21. Anderson MC, Schoenfeld FB, Iams WB, Suwa M. Circulatory changes in acute pancreatitis. Surg Clin North Am. 1967;47:127-40.
22. Wulff K, Sjostrom B. Influence of acute pancreatitis on central hemodynamic, regional blood flow distribution and arteriovenous shunting in the dog. Eur Surg Res. 1974;6:354-63.
23. Kinnala PJ, Kuttila KT, Grönroos JM, Havia TV, Nevalainen TJ, Niinikoski J. Central haemodynamics in experimental acute pancreatitis. Eur J Surg. 1999;165:598-603.
24. Weingartner R, Oliveira E, Oliveira ES, Sant'Anna UL, Oliveira RP, Azambuja LA, Friedman G. Blockade of the action of nitric oxide in human septic shock increases systemic vascular resistance and has detrimental effects on pulmonary function after a short infusion of methylene blue. Braz J Med Biol Res. 1999;32:1505-13.
25. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med. 1999;340:207-14.
26. Cobo JC, Abraham E, Bland RD, Shoemaker WC. Sequential hemodynamic and oxygen transport abnormalities in patients with acute pancreatitis. Surgery. 1984;95:324-30.
27. Keaney JF Jr, Puyana JC, Francis S, Loscalzo JF, Stamler JS, Loscalzo J. Methylene blue reverses endotoxin-induced hypotension. Circ Res. 1994;74:1121-5.
28. Mayer B, Brunner F, Schmidt K. Inhibition of nitric oxide synthesis by methylene blue. Biochem Pharmacol. 1993;45:367-74.
29. Sanfey H, Sarr MG, Bulkley GB, Cameron JL. Oxygen-derived free radicals and acute pancreatitis: a review. Acta Physiol Scand Suppl. 1986;548:109-18.
30. Niederau C, Niederau M, Borchard F, Ude K, Lüthen R, Strohmeyer G, Ferrell LD, Grendell JH. Effects of antioxidants and free radical scavengers in three different models of acute pancreatitis. Pancreas. 1992;7:486-96.
31. Suematsu M, Tamatani T, Delano FA, Miyasaka M, Forrest M, Suzuki H, Schmid-Schönbein GW. Microvascular oxidative stress preceding leukocyte activation elicited by in vivo nitric oxide suppression. Am J Physiol. 1994;266:H2410-5.
32. Kurose I, Wolf R, Grisham MB, Aw TY, Specian RD, Granger DN. Microvascular responses to inhibition of nitric oxide production. Role of active oxidants. Circ Res. 1995;76:30-9.
33. Marczin N, Ryan US, Catravas JD. Methylene blue inhibits nitrovasodilator- and endothelium-derived relaxing factor-induced cyclic GMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion. J Pharmacol Exp Ther. 1992;263:170-9.
34. Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol. 1986;250:H822-7.
35. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A. 1990;87:1620-4.
36. Viola G, al-Mufti RA, Sohail M, Williamson RC, Mathie RT. Nitric oxide induction in a rat model of selective pancreatic ischemia and reperfusion. Hepatogastroenterology. 2000;47:1250-5.
37. Kilbourn RG, Jubran A, Gross SS, Griffith OW, Levi R, Adams J, Lodato RF. Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun. 1990;172:1132-8.
38. Petros A, Lamb G, Leone A, Moncada S, Bennett D, Vallance P. Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res. 1994;28:34-9.
39. Nava E, Palmer RM, Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet. 1991;338:1555-7.
40. Konturek SJ, Bilski J, Konturek PK, Cieszkowski M, Pawlik W. Role of endogenous nitric oxide in the control of canine pancreatic secretion and blood flow. Gastroenterology. 1993;104:896-902.
41. Liu X, Nakano I, Yamaguchi H, Ito T, Goto M, Koyanagi S, Kinjoh M, Nawata H. Protective effect of nitric oxide on development of acute pancreatitis in rats. Dig Dis Sci. 1995;40:2162-9.
42. Werner J, Rivera J, Fernandez-del Castillo C, Lewandrowski K, Adrie C, Rattner DW, Warshaw AL. Differing roles of nitric oxide in the pathogenesis of acute edematous versus necrotizing pancreatitis. Surgery. 1997;121:23-30.
43. Werner J, Fernández-del Castillo C, Rivera JA, Kollias N, Lewandrowski KB, Rattner DW, Warshaw AL. On the protective mechanisms of nitric oxide in acute pancreatitis. Gut. 1998;43:401-7.
44. Levy M, Geller R, Hymovitch S. Renal failure in dogs with experimental acute pancreatitis: role of hypovolemia. Am J Physiol. 1986;251:F969-77.
45. Southern C, Schulster D, Green IC. Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism. FEBS Lett. 1990;276:42-4.
46. Kolb H, Kolb-Bachofen V. Type 1 (insulin-dependent) diabetes mellitus and nitric oxide. Diabetologia. 1992;35:796-7.