The role of C4d immunostaining in the evaluation of the causes of renal allograft dysfunction

Nephrology Dialysis Transplantation

Volumn 23, Issue 5, 2008, Pages 1735-1741

  Ranjan, Prabhat ^a   Nada, Ritambhra ^a   Jha, Vivekanand ^a   Sakhuja, Vinay ^a   Joshi, Kusum ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Antibody mediated rejection; C4d; Cellular rejection; Renal transplant

Indexed keywords

AZATHIOPRINE; CD4 ANTIGEN; CYCLOSPORIN; PREDNISONE;

ACUTE KIDNEY TUBULE NECROSIS; ADULT; ANTIGEN ANTIBODY REACTION; ARTICLE; CAPILLARY PERMEABILITY; CREATININE BLOOD LEVEL; FEMALE; GLOMERULOPATHY; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY DISEASE; KIDNEY GRAFT REJECTION; LEUKOCYTE MIGRATION; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; NEPHRECTOMY; PREVALENCE; PRIORITY JOURNAL; RENAL GRAFT DYSFUNCTION;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; BIOPSY, NEEDLE; CHILD; COMPLEMENT C4B; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 44449172961     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm843     Document Type: Article

References (21)

1. Solez K, Axelsen RA, Benediktsson H et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection. The Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411-422
2. Racusen L, Solez K, Colvin RB et al. The Banff 97 working classification of kidney allograft pathology. Kidney Int 1999; 55: 713-723
3. Piazza A, Poggi E, Borrelli L et al. Impact of donor-specific antibodies on chronic rejection occurrence and graft loss in renal transplantation. Post-transplant analysis using flow cytometric techniques. Transplantation 2001; 71: 1106-1112
4. Racusen LC, Colvin RB, Solez K et al. Antibody-mediated rejection criteria - an addition to the Banff'97 classification of renal allograft rejection. Am J Transplant 2003; 3: 703-714
5. Platt JL. C4d and the fate of organ allografts. J Am Soc Nephrol 2002; 13: 2417-2419
6. Nickeleit V, Mihatsch MJ. Kidney transplants, antibodies and rejection: is C4d a magic marker? Nephrol Dial Transplant 2003; 18: 2232-2239
7. Feucht HE, Felber E, Gokel MJ et al. Vascular deposition of complement - split products in kidney allografts with cell-mediated rejection. Clin Exp Immunol 1991; 86: 464-470
8. Collins AB, Schneeberger EE, Pascual MA et al. Complement activation, in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol 1999; 10: 2208-2214
9. Herzenberg AM, Gill JS, Djurdjev O et al. C4d deposition in acute rejection: an independent long-termprognostic factor. J Am Soc Nephrol 2002; 13: 234-241
10. Finkilstein FO, Siegel NJ, Bastl C et al. Kidney transplant biopsies in the diagnosis and management of acute rejections. Kidney Int 1976; 10: 171-176
11. Feucht HE, Felber E, Gokel MJ et al. Vascular deposition of complement - split products in kidney allografts with cell-mediated rejection. Clin Exp Immunol 1991; 86: 464-470
12. Mauiyyedi S, Crespo M, Collins AB et al. Acute humoral rejection in kidney transplant: II. Morphology, immunopathology and pathologic classification. J Am Soc Nephrol 2002; 13: 779-787
13. Scornik JC, LeFor WM, Cicciarelli JC et al. Hyperacute and acute graft rejection to antibodies against B cells. Transplantation 1992; 54: 61-64
14. Lederer SR, Kluth-Pepper B, Schneeberger H et al. Impact of humoral alloreactivity early after transplantation on the long term survival of renal allografts. Kidney Int 2001; 59: 334-341
15. Nickeleit V, Zeiler M, Gudat F et al. Detection of the complement degradation product C4d in renal allografts: diagnostic and therapeutic implications. J Am Soc Nephrol 2002; 13: 242-251
16. Regele H, Exner M, Watschinger B et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001; 16: 2058-2066
17. Herman J, Lerut E, Van Damme-Lombaerts R et al. Capillary deposition of complement C4d and C3d in pediatric renal allograft biopsies. Transplantation 2005; 79: 1435-1440
18. Tipkov K, Campbell P, Pazderka F et al. Pathologic features of acute renal allograft rejection associated with donor-specific antibody. Analysis using the Banff grading scheme. Transplantation 1996; 61: 1586-1592
19. Shimizu A, Colvin R.B, Yamanaka N. Rejection of peritubular capillaries in renal allo- and xeno-grafts. Clin Transplant 2000; 14: 6-14
20. Ozdemir BH, Demirhan B, OZdemir FN et al. The role of microvascular injury on steroid and OKT3 response in renal allograft rejection. Transplantation 2004; 78: 734-740
21. Mauiyyedi S, Pelle P, Saidman S et al. Chronic humoral rejection. Identification of antibody mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 2001; 12: 574-582