Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly(vinyl alcohol) gel

International Journal of Pharmaceutics

Volumn 358, Issue 1-2, 2008, Pages 36-43

  Ivanov, Alexander E ^a,b   Nilsson, Lars ^a   Galaev, Igor Yu ^a   Mattiasson, Bo ^a  

^a LUND UNIVERSITY   (Sweden)

^b Ideon Science Park   (Sweden)

Author keywords

Boronic acid; Controlled release; Drug delivery; Mucoadhesive; Smart material

Indexed keywords

ACRYLAMIDE; BICARBONATE; BORATE SODIUM; BORONIC ACID DERIVATIVE; BUFFER; CHITOSAN; COPOLYMER; FRUCTOSE; MUCIN; N ACRYLOYL 3 AMINOPHENYLBORONIC ACID; N,N DIMETHYLACRYLAMIDE; NANOPARTICLE; POLYACRYLIC ACID; POLYVINYL ALCOHOL; SODIUM CHLORIDE; SUGAR;

ALKALINITY; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CATHETER; COACERVATION; COMPLEX FORMATION; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GEL; HYDRODYNAMICS; INJECTION; IONIC STRENGTH; MACROMOLECULE; MALE; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; STOMACH; STOMACH EPITHELIUM; STOMACH MUCOSA; SWINE; URETHRA; WEIGHT; ZETA POTENTIAL;

ANIMALS; AZASTEROIDS; BORONIC ACIDS; DIHYDROTESTOSTERONE; GELS; INDICATORS AND REAGENTS; LIGHT; MOLECULAR WEIGHT; MUCINS; MUCOUS MEMBRANE; NEPHELOMETRY AND TURBIDIMETRY; POLYMERS; POLYVINYL ALCOHOL; SCATTERING, RADIATION; SILICONE ELASTOMERS; SWINE; URETHRA;

EID: 44449157070     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.02.017     Document Type: Article

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