Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region

FEBS Letters

Volumn 582, Issue 13, 2008, Pages 1894-1900

  Li, Ting ^a,b   Yu, Xiu Ju ^a   Zhang, Guang Yi ^a,b  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

c Jun NH2 terminal kinase (JNK); Cerebral ischemia; HPK1; N methyl d aspartate receptor (NMDAR); Neuroprotection; Src

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; DIZOCILPINE; HEMATOPOIETIC PROGENITOR KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MIXED LINEAGE KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN C JUN; PROTEIN TYROSINE KINASE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN REGION; CELL DEATH; CONTROLLED STUDY; HIPPOCAMPUS; HISTOLOGY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; NERVE CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION; STATISTICAL SIGNIFICANCE;

ANIMALS; BRAIN ISCHEMIA; CYTOPROTECTION; DIZOCILPINE MALEATE; HIPPOCAMPUS; MALE; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 10; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TYROSINE;

RATTUS;

EID: 44449150281     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.05.009     Document Type: Article

References (25)

1. Kiefer F., et al. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 15 (1996) 7013-7025
2. Hu M.C., Qiu W.R., Wang X., Meyer C.F., and Tan T.H. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes Dev. 10 (1996) 2251-2264
3. Boomer J.S., and Tan T.H. Functional interactions of HPK1 with adaptor proteins. J. Cell. Biochem. 95 (2005) 34-44
4. Anafi M., Kiefer F., Gish G.D., Mbamalu G., Iscove N.N., and Pawson T. SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1. J. Biol. Chem. 272 (1997) 27804-27811
5. Ling P., et al. Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. J. Biol. Chem. 276 (2001) 18908-18914
6. Ling P., Yao Z., Meyer C.F., Wang X.S., Oehrl W., Feller S.M., and Tan T.H. Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. Mol. Cell Biol. 19 (1999) 1359-1368
7. Liou J., Kiefer F., Dang A., Hashimoto A., Cobb M.H., Kurosaki T., and Weiss A. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity 12 (2000) 399-408
8. Oehrl W., et al. The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene 17 (1998) 1893-1901
9. Sauer K., Liou J., Singh S.B., Yablonski D., Weiss A., and Perlmutter R.M. Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. J. Biol. Chem. 276 (2001) 45207-45216
10. Ensenat D., Yao Z., Wang X.S., Kori R., Zhou G., Lee S.C., and Tan T.H. A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1. J. Biol. Chem. 274 (1999) 33945-33950
11. Wang W., Zhou G., Hu M.C., Yao Z., and Tan T.H. Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction. J. Biol. Chem. 272 (1997) 22771-22775
12. Zhou G., Lee S.C., Yao Z., and Tan T.H. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. J. Biol. Chem. 274 (1999) 13133-13138
13. Nagata Y., Kiefer F., Watanabe T., and Todokoro K. Activation of hematopoietic progenitor kinase-1 by erythropoietin. Blood 93 (1999) 3347-3354
14. Chen Y.R., Meyer C.F., Ahmed B., Yao Z., and Tan T.H. Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). Oncogene 18 (1999) 7370-7377
15. Sawasdikosol S., Russo K.M., and Burakoff S.J. Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2-induced fos gene transcription. Blood 101 (2003) 3687-3689
16. Mabuchi T., et al. Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo. J. Neurosci. 21 (2001) 9204-9213
17. Hanke J.H., Gardner J.P., Dow R.L., Changelian P.S., Brissette W.H., Weringer E.J., et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271 (1996) 695-701
18. Pulsinelli W.A., and Brierley J.B. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10 (1979) 267-272
19. Hou X.Y., Liu Y., and Zhang G.Y. PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci. Lett. 420 (2007) 235-239
20. Zhang F., Li C., Wang R., Han D., Zhang Q.G., Zhou C., et al. Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion. Neuroscience 150 (2007) 938-949
21. Goodsell D.S. The molecular perspective: the Src oncogene. Stem Cells 19 (2001) 553-555
22. Tezuka T., Umemori H., Akiyama T., Nakanishi S., and Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-d-aspartate receptor subunit NR2A. Proc. Natl. Acad. Sci. USA 96 (1999) 435-440
23. Sala C., and Sheng M. The fyn art of N-methyl-d-aspartate receptor phosphorylation. Proc. Natl. Acad. Sci. USA 96 (1999) 335-337
24. Lee J.M., Zipfel G.J., and Choi D.W. The changing landscape of ischaemic brain injury mechanisms. Nature 399 (1999) A7-A14
25. Li T., Han D., Chen J., Yu X.J., and Zhang G.Y. Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression. Neuroreport 19 (2008) 647-651