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Volumn 65, Issue 10, 2008, Pages 1596-1608

Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2

Author keywords

Acylcarnitines; Drug carnitine interactions; hOCTN2; Secondary carnitine deficiency; Stable transfection; Verapamil

Indexed keywords

CARNITINE; MESSENGER RNA; PROTEIN OCTN 2;

EID: 44449145850     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-8065-7     Document Type: Article
Times cited : (19)

References (39)
  • 1
    • 0021024932 scopus 로고
    • Carnitine - Metabolism and functions
    • Bremer, J. (1983) Carnitine - Metabolism and functions. Physiol. Rev. 63, 1420-1480.
    • (1983) Physiol. Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 2
    • 0000308368 scopus 로고
    • The effects of muscle extracts on the oxidation of palmitic acid by liver slices and homogenates
    • Fritz, I. B. (1955) The effects of muscle extracts on the oxidation of palmitic acid by liver slices and homogenates. Acta Physiol. Scand. 34, 367-385.
    • (1955) Acta Physiol. Scand , vol.34 , pp. 367-385
    • Fritz, I.B.1
  • 3
    • 0025372395 scopus 로고
    • The role of carnitine in intracellular metabolism
    • Bremer, J. (1990) The role of carnitine in intracellular metabolism. J. Clin. Chem. Clin. Biochem. 28, 297-301.
    • (1990) J. Clin. Chem. Clin. Biochem , vol.28 , pp. 297-301
    • Bremer, J.1
  • 4
    • 0024246260 scopus 로고
    • Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts
    • Treem, W. R., Stanley, C. A., Finegold, D. N., Hale, D. E. and Coates, P. M. (1988) Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts. N. Engl. J. Med. 319, 1331-1336.
    • (1988) N. Engl. J. Med , vol.319 , pp. 1331-1336
    • Treem, W.R.1    Stanley, C.A.2    Finegold, D.N.3    Hale, D.E.4    Coates, P.M.5
  • 5
    • 0035815991 scopus 로고    scopus 로고
    • Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney
    • Tamai, I., China, K., Sai, Y., Kobayashi, D., Nezu, J., Kawahara, E. and Tsuji, A. (2001) Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim. Biophys. Acta 1512, 273-284.
    • (2001) Biochim. Biophys. Acta , vol.1512 , pp. 273-284
    • Tamai, I.1    China, K.2    Sai, Y.3    Kobayashi, D.4    Nezu, J.5    Kawahara, E.6    Tsuji, A.7
  • 6
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • Tamai, I., Ohashi, R., Nezu, J., Yabuuchi, H., Oku, A., Shimane, M., Sai, Y. and Tsuji, A. (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem. 273, 20378-20382.
    • (1998) J. Biol. Chem , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3    Yabuuchi, H.4    Oku, A.5    Shimane, M.6    Sai, Y.7    Tsuji, A.8
  • 7
    • 0032767691 scopus 로고    scopus 로고
    • Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
    • Wu, X., Huang, W., Prasad, P. D., Seth, P., Rajan, D. P., Leibach, F. H., Chen, J., Conway, S. J. and Ganapathy, V. (1999) Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J. Pharmacol. Exp. Ther. 290, 1482-1492.
    • (1999) J. Pharmacol. Exp. Ther , vol.290 , pp. 1482-1492
    • Wu, X.1    Huang, W.2    Prasad, P.D.3    Seth, P.4    Rajan, D.P.5    Leibach, F.H.6    Chen, J.7    Conway, S.J.8    Ganapathy, V.9
  • 8
    • 0032577202 scopus 로고    scopus 로고
    • cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
    • Wu, X., Prasad, P. D., Leibach, F. H. and Ganapathy, V. (1998) cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem. Biophys. Res. Commun. 246, 589-595.
    • (1998) Biochem. Biophys. Res. Commun , vol.246 , pp. 589-595
    • Wu, X.1    Prasad, P.D.2    Leibach, F.H.3    Ganapathy, V.4
  • 10
    • 0033517087 scopus 로고    scopus 로고
    • Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: A novel Arg169Gln mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality
    • Burwinkel, B., Kreuder, J., Schweitzer, S., Vorgerd, M., Gempel, K., Gerbitz, K. D. and Kilimann, M. W. (1999) Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: A novel Arg169Gln mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality. Biochem. Biophys. Res. Commun. 261, 484-487.
    • (1999) Biochem. Biophys. Res. Commun , vol.261 , pp. 484-487
    • Burwinkel, B.1    Kreuder, J.2    Schweitzer, S.3    Vorgerd, M.4    Gempel, K.5    Gerbitz, K.D.6    Kilimann, M.W.7
  • 11
    • 0005419068 scopus 로고    scopus 로고
    • Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency
    • Mayatepek, E., Nezu, J., Tamai, I., Oku, A., Katsura, M., Shimane, M. and Tsuji, A. (2000) Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency. Hum. Mutat. 15, 118.
    • (2000) Hum. Mutat , vol.15 , pp. 118
    • Mayatepek, E.1    Nezu, J.2    Tamai, I.3    Oku, A.4    Katsura, M.5    Shimane, M.6    Tsuji, A.7
  • 14
    • 0032997735 scopus 로고    scopus 로고
    • Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency
    • Tang, N. L., Ganapathy, V., Wu, X., Hui, J., Seth, P., Yuen, P. M., Wanders, R. J., Fok, T. F. and Hjelm, N. M. (1999) Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency. Hum. Mol. Genet. 8, 655-660.
    • (1999) Hum. Mol. Genet , vol.8 , pp. 655-660
    • Tang, N.L.1    Ganapathy, V.2    Wu, X.3    Hui, J.4    Seth, P.5    Yuen, P.M.6    Wanders, R.J.7    Fok, T.F.8    Hjelm, N.M.9
  • 16
    • 0032544981 scopus 로고    scopus 로고
    • Carnitine uptake defect: Frameshift mutations in the human plasmalemmal carnitine transporter gene
    • Lamhonwah, A. M. and Tein, I. (1998) Carnitine uptake defect: Frameshift mutations in the human plasmalemmal carnitine transporter gene. Biochem. Biophys. Res. Commun. 252, 396-401.
    • (1998) Biochem. Biophys. Res. Commun , vol.252 , pp. 396-401
    • Lamhonwah, A.M.1    Tein, I.2
  • 17
    • 0033515017 scopus 로고    scopus 로고
    • Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency
    • Wang, Y., Ye, J., Ganapathy, V. and Longo, N. (1999) Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency. Proc. Natl. Acad. Sci. USA 96, 2356-2360.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2356-2360
    • Wang, Y.1    Ye, J.2    Ganapathy, V.3    Longo, N.4
  • 20
    • 10644296222 scopus 로고    scopus 로고
    • Carnitines and its congeners: A metabolic pathway to the regulation of immune response and inflammation
    • Famularo, G., De Simone, C., Trinchieri, V. and Mosca, L. (2004) Carnitines and its congeners: A metabolic pathway to the regulation of immune response and inflammation. Ann. N. Y. Acad. Sci. 1033, 132-138.
    • (2004) Ann. N. Y. Acad. Sci , vol.1033 , pp. 132-138
    • Famularo, G.1    De Simone, C.2    Trinchieri, V.3    Mosca, L.4
  • 21
    • 10644296223 scopus 로고    scopus 로고
    • Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: A review
    • Ferrari, R., Merli, E., Cicchitelli, G., Mele, D., Fucili, A. and Ceconi, C. (2004) Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: A review. Ann. N. Y. Acad. Sci. 1033, 79-91.
    • (2004) Ann. N. Y. Acad. Sci , vol.1033 , pp. 79-91
    • Ferrari, R.1    Merli, E.2    Cicchitelli, G.3    Mele, D.4    Fucili, A.5    Ceconi, C.6
  • 23
    • 0019941501 scopus 로고
    • Carnitine deficiency and hyperammonemia associated with valproic acid therapy
    • Ohtani, Y., Endo, F. and Matsuda, I. (1982) Carnitine deficiency and hyperammonemia associated with valproic acid therapy. J. Pediatr. 101, 782-785.
    • (1982) J. Pediatr , vol.101 , pp. 782-785
    • Ohtani, Y.1    Endo, F.2    Matsuda, I.3
  • 24
  • 26
    • 0032696186 scopus 로고    scopus 로고
    • Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
    • Ohashi, R., Tamai, I., Yabuuchi, H., Nezu, J. I., Oku, A., Sai, Y., Shimane, M. and Tsuji, A. (1999) Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance. J. Pharmacol. Exp. Ther. 291, 778-784.
    • (1999) J. Pharmacol. Exp. Ther , vol.291 , pp. 778-784
    • Ohashi, R.1    Tamai, I.2    Yabuuchi, H.3    Nezu, J.I.4    Oku, A.5    Sai, Y.6    Shimane, M.7    Tsuji, A.8
  • 30
    • 0034296940 scopus 로고    scopus 로고
    • Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes
    • Salmon, P., Oberholzer, J., Occhiodoro, T., Morel, P., Lou, J. and Trono, D. (2000) Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol. Ther. 2, 404-414.
    • (2000) Mol. Ther , vol.2 , pp. 404-414
    • Salmon, P.1    Oberholzer, J.2    Occhiodoro, T.3    Morel, P.4    Lou, J.5    Trono, D.6
  • 31
    • 0000187958 scopus 로고    scopus 로고
    • Applications of the Cambridge Structural Database in organic chemistry and crystal chemistry
    • Allen, F. H. and Motherwell, W. D. (2002) Applications of the Cambridge Structural Database in organic chemistry and crystal chemistry. Acta Crystallogr. B 58, 407-422.
    • (2002) Acta Crystallogr. B , vol.58 , pp. 407-422
    • Allen, F.H.1    Motherwell, W.D.2
  • 33
    • 0017876814 scopus 로고
    • Carnitine metabolism in the fasting rat
    • Brass, E. P. and Hoppel, C. L. (1978) Carnitine metabolism in the fasting rat. J. Biol. Chem. 253, 2688-2693.
    • (1978) J. Biol. Chem , vol.253 , pp. 2688-2693
    • Brass, E.P.1    Hoppel, C.L.2
  • 36
    • 0037727758 scopus 로고    scopus 로고
    • Beneficial effects of L-carnitine in myoblastic C2C12 cells. Interaction with zidovudine
    • Georges, B., Galland, S., Rigault, C., Le Borgne, F. and Demarquoy, J. (2003) Beneficial effects of L-carnitine in myoblastic C2C12 cells. Interaction with zidovudine. Biochem. Pharmacol. 65, 1483-1488.
    • (2003) Biochem. Pharmacol , vol.65 , pp. 1483-1488
    • Georges, B.1    Galland, S.2    Rigault, C.3    Le Borgne, F.4    Demarquoy, J.5
  • 37
    • 0035209172 scopus 로고    scopus 로고
    • Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier
    • Kido, Y., Tamai, I., Ohnari, A., Sai, Y., Kagami, T., Nezu, J., Nikaido, H., Hashimoto, N., Asano, M. and Tsuji, A. (2001) Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. J. Neurochem. 79, 959-969.
    • (2001) J. Neurochem , vol.79 , pp. 959-969
    • Kido, Y.1    Tamai, I.2    Ohnari, A.3    Sai, Y.4    Kagami, T.5    Nezu, J.6    Nikaido, H.7    Hashimoto, N.8    Asano, M.9    Tsuji, A.10
  • 39
    • 39049170302 scopus 로고    scopus 로고
    • Characteristics of L-carnitine import into heart cells
    • Rigault, C., Dias, J. V., Demarquoy, J. and Le Borgne, F. (2008) Characteristics of L-carnitine import into heart cells. Biochimie 90, 542-546.
    • (2008) Biochimie , vol.90 , pp. 542-546
    • Rigault, C.1    Dias, J.V.2    Demarquoy, J.3    Le Borgne, F.4


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