Changes in total ghrelin within the somatotropic axis in severe burn patients: Comparison of those with inhalation injury and those without inhalation injury

Growth Hormone and IGF Research

Volumn 18, Issue 4, 2008, Pages 291-297

  Lee, B W ^a   Park, S H ^a   Ihm, S H ^a   Kim, J H ^b   Kim, D H ^b   You, K C ^b   Kim, S W ^c   Yoo, H J ^a  

^a Hangang Sacred Heart Hospital   (South Korea)

^b Hallym University   (South Korea)

^c Biomedical Science Institute   (South Korea)

Author keywords

Ghrelin; Growth hormone; IGF 1; IGFBP 3; Inhalation injury; Severe burn

Indexed keywords

GHRELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HYDROCORTISONE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GROWTH HORMONE BLOOD LEVEL; HORMONE ACTION; HORMONE DETERMINATION; HORMONE RESPONSE; HORMONE SYNTHESIS; HUMAN; HYDROCORTISONE BLOOD LEVEL; LUNG BURN; MALE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRESS;

ADULT; AGED; BURNS; FEMALE; GHRELIN; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SIGNAL TRANSDUCTION; SMOKE INHALATION INJURY; SOMATOTROPHS; TIME FACTORS;

EID: 44449142915     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2007.11.005     Document Type: Article

References (26)

1. Melmed S. Medical progress: acromegaly. N. Engl. J. Med. 355 (2006) 2558-2573
2. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
3. Ghelardoni S., Carnicelli V., Frascarelli S., Ronca-Testoni S., and Zucchi R. Ghrelin tissue distribution: comparison between gene and protein expression. J. Endocrinol. Invest. 29 (2006) 115-121
4. Lely A.J., Tschop M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocrine Rev. 25 (2004) 426-457
5. Tannenbaum G.S., Epelbaum J., and Bowers C.Y. Interrelationship between the novel peptide ghrelin and somatostatin/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion. Endocrinology 144 (2003) 967-974
6. Van den Berghe G., de Zegher F., and Bouillon R. Acute and prolonged critical illness as different neuroendocrine paradigms. J. Clin. Endocrinol. Metab. 83 (1998) 1827-1834
7. Baxter R.C., Hawker F.H., To C., et al. Thirty-day monitoring of insulin-like growth factors and their binding proteins in intensive care unit patients. Growth Horm. IGF Res. 8 (1998) 455-463
8. Defalque D., Brandt N., Ketelslegers J.M., et al. GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors. Am. J. Physiol. 276 (1999) E565-E572
9. Gianotti L., Stella M., Bollero D., et al. Activity of GH/IGF-1 axis in burn patients: comparison with normal subjects and patients with GH deficiency. J. Endocrinol. Invest. 25 (2002) 116-1124
10. Van den Berghe G. Growth hormone secretagogues in critical Illness. Horm. Res. 51 Suppl. 3 (1999) 21-28
11. Tobiasen J., Hiebert J.M., and Edlich R.F. The abbreviated burn severity index. Ann. Emerg. Med. 11 (1982) 260-262
12. Andel D., Kamolz L.P., Niedermayr M., et al. Which of the abbreviated burn severity index variables are having impact on the hospital length of stay?. J. Burn Care. Res. 28 (2007) 163-166
13. Knaus W.A., Draper E.A., Wagner D.P., et al. APACHE II: a severity of disease classification system. Crit. Care Med. 13 (1985) 818-829
14. Khoo A.K., Lee S.T., and Poh W.T. Tracheobronchial cytology in inhalation injury. J. Trauma 42 (1997) 81-85
15. Long C.L., Schaffel N., Geiger J.W., Schiller W.R., and Blakemore W.S. Metabolic response to injury and illness: estimation of energy and protein needs from indirect calorimetry and nitrogen balance. J. Parenter. Enteral. Nutr. 3 (1979) 452-456
16. Hermansson M., Wickelgren R.B., Hammarqvist F., et al. Measurement of human growth hormone receptor messenger ribonucleic acid by a quantitative polymerase chain reaction-based assay: demonstration of reduced expression after elective surgery. J. Clin. Endocrinol. Metab. 82 (1997) 421-428
17. Kim S.W., Kim K.W., Shin C.S., et al. Acylated ghrelin secretion is acutely suppressed by oral glucose load or insulin-induced hypoglycemia independently of basal growth hormone secretion in humans. Horm. Res. 67 (2007) 211-219
18. Huber J., Reiterer E.E., Sudi K., et al. Ghrelin does not regulate the GH response to insulin-induced hypoglycaemia in children but could be involved in the regulation of cortisol secretion. Clin. Endocrinol. 66 (2007) 143-147
19. Broglio F., Gottero C., Prodam F., et al. Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans. Clin. Endocrinol. 61 (2004) 503-509
20. Otto B., Tschop T., Heldwein W., Pfeiffer A.F., and Diederich S. Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. Eur. J. Endocrinol. 151 (2004) 113-117
21. Libè R., Morpurgo P.S., Cappiello V., et al. Ghrelin and adiponectin in patients with Cushing's disease before and after successful transsphenoidal surgery. Clin. Endocrinol. 62 (2005) 30-36
22. Giordano R., Picu A., Pagotto U., et al. The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing's disease. Eur. J. Endocrinol. 153 (2005) 535-543
23. Katsuki A., Urakawa H., Gabazza E.C., et al. Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. Eur. J. Endocrinol. 151 (2004) 573-577
24. Pöykkö S.M., Kellokoski E., Hörkkö S., Kauma H., Kesäniemi Y.A., and Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 52 (2003) 2546-2553
25. Balasubramaniam A., Wood S., Joshi R., et al. Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin. Peptides 27 (2006) 1624-1631
26. Toshinai K., Yamaguchi H., Sun Y., et al. Acylated ghrelin and des-acyl ghrelin exert different effects on the gastrointestinal motility in conscious rats. Endocrinology 147 (2006) 2306-2314