First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 6, 2008, Pages 2283-2284

  Savini, Helene ^a   Bogreau, Hervé ^b   Bertaux, Lionel ^c   Bouchiba, Housem ^b   Kraemer, Philippe ^a   Parzy, Daniel ^c   Garnotel, Eric ^a   Rogier, Christophe ^b   Simon, Fabrice ^b   Pradines, Bruno ^b  

^a LAVERAN MILITARY TEACHING HOSPITAL   (France)

^b CNRS   (France)

^c SERVICE DE SANTÉ DES ARMÉES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ATOVAQUONE PLUS PROGUANIL; CHLOROQUINE; QUININE;

ADULT; CASE REPORT; DHFR GENE; GENE; GENE MUTATION; GENOTYPE; HUMAN; IC 50; LETTER; MALARIA FALCIPARUM; PFCRT GENE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTOZOAL GENETICS; TRAVEL;

EID: 44449142851     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00282-08     Document Type: Letter

References (14)

1. Bogreau, H., F. Renaud, H. Bouchiba, P. Durand, S. B. Assi, M. C. Henry, E. Garnotel, B. Pradines, T. Fusai, B. Wade, E. Adehissi, P. Parola, M. A. Kamil, O. Puijalon, and C. Rogier. 2006. Genetic diversity and structure of African Plasmodium falciparum populations in urban and rural areas. Am. J. Trop. Med. Hyg. 74:953-959.
2. David, K. P., M. Alifrangis, A. Salanti, L. S. Vestergaard, A. Ronn, and I. Bygbjerg. 2003. Atovaquone/proguanil resistance in Africa: a case report. Scand. J. Infect. Dis. 35:897-898.
3. Farnert, A., J. Lindberg, P. Gil, G. Swedberg, Y. Berqvist, M. M. Thapar, N. Lindegardh, S. Berezcky, and A. Bjorkman. 2003. Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case report. BMJ. 326:628-629.
4. Fivelman, Q. L., G. A. Butcher, I. S. Adagu, D. C. Warhurst, and G. Pasvol. 2002. Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria. Malar. J. 1:1.
5. Henry, M., I. Diallo, J. Bordes, S. Ka, B. Pradines, B. Diatta, P. S. M'Baye, M. Sane, M. Thiam, P. M. Gueye, B. Wade, J. E. Touze, J. M. Debonne, C. Rogier, and T. Fusai. 2006. Urban malaria in Dakar: chemosusceptibility and genetic diversity of Plasmodium falciparum isolates. Am. J. Trop. Med. Hyg. 75:146-151.
6. Khun, S., M. J. Gill, and K. C. Kain. 2005. Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to West Africa. Am. J. Trop. Med. Hyg. 72:407-409.
7. Legrand, E., M. Demar, B. Volney, M. T. Ekala, M. Quinternet, C. Bouchier, T. Fandeur, C. Rogier, B. Carme, O. Mercereau-Puijalon, and P. Esterre. 2007. First case of emergence of atovaquone resistance in Plasmodium falciparum during second-line atovaquone-proguanil treatment in South America. Antimicrob. Agents Chemother. 51:2280-2281.
8. Looreesuwan, S., C. Viravan, H. K. Webster, D. E. Kyle, D. B. Hutchinson, and C. J. Canfield. 1996. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am. J. Trop. Med. Hyg. 54:62-66.
9. Musset, L., O. Bouchaud, S. Matheron, L. Massias, and J. Le Bras. 2006. Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon mutations. Microb. Infect. 8:2599-2604.
10. Musset, L., B. Pradines, D. Parzy, R. Durand, P. Bigot, and J. Le Bras. 2006. Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers. J. Antimicrob. Chemother. 57:110-115.
11. Painter, H. J., J. M. Morrissey, M. W. Mather, and A. B. Vaidya. 2007. Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446:88-91.
12. Parola, P., B. Pradines, F. Simon, M. P. Carlotti, P. Minodier, M. P. Ranjeva, S. Badiaga, L. Bertaux, J. Delmont, M. Morillon, R. Silai, P. Brouqui, and D. Parzy. 2007. Antimalarial drug susceptibility and point mutations associated with drug resistance in 248 Plasmodium falciparum isolates imported from Comoros to Marseille, France in 2004-2006. Am. J. Trop. Med. Hyg. 77:431-437.
13. Schwartz, E., S. Bujanover, and K. C. Kain. 2003. Genetic confirmation of atovaquone-proguanil resistant Plasmodium falciparum malaria acquired by a nonimmune traveller to east Africa. Clin. Infect. Dis. 37:450-451.
14. Schwobel, B., M. Alifrangis, A. Salanti, and T. Jelinek. 2003. Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker. Malar. J. 2:5.