3,3-diindolylmethane enhances the inhibitory effect of idarubicin on the growth of human prostate cancer cells

National Medical Journal of China

Volumn 88, Issue 10, 2008, Pages 661-664

  Zhao, Yan Ying ^a   Zhou, Le ^a   Pan, Yu Zhuo ^a   Zhao, Li Juan ^a   Liu, Ya Nan ^a   Yu, Hao ^a   Li, Yang ^a   Zhao, Xue Jian ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Apoptosis; DIM; IDA; Prostatic neoplasms

Indexed keywords

3,3 DIINDOLYLMETHANE; ACRIDINE ORANGE; ANTINEOPLASTIC AGENT; CASPASE 9; IDARUBICIN; MESSENGER RNA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; NITROBLUE TETRAZOLIUM TEST; PROSTATE CANCER; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IDARUBICIN; INDOLES; MALE; MATRIX METALLOPROTEINASE 9; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 44449142397     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Majsiterek I, Gloc E, Blasiak J, et al. A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells. Pineal Res, 2005,38:254-263.
2. Chinese source.
3. Lee SH, Kim JS, Yamaguchi K, et al. Indole-3-carbinol and 3,3-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem Biophys Res Commun, 2005,328:63-69.
4. Chinni SR, Li Y, Upadhyay S, et al. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene, 2001,20:2927-2936.
5. Chinese source.
6. Cohen JH, Kristal AR, Stanford JL, et al. High consumption of vegetables associated with reduced risk of prostate cancer. Evidence-based Oncology, 2000,1:69-70.
7. Venkata PS, Badithe TG, Tadi AK, et al. Synthetic dimerof indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer. Prostate, 2006,66:453-462.
8. Savino JA, Evans JF, Rabinowitz D, et al. Multiple disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane. Mol Cancer Ther, 2006,5:556-563.
9. Rahman KM, Aranha O, Glazyrin A,et al. Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells. Oncogene, 2000,19:5764-5771.
10. Chinese source.