Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region

Gene

Volumn 417, Issue 1-2, 2008, Pages 5-12

  Zhang, Jian ^a   Chen, Suning ^b   Zhang, Wei ^a   Zhang, Jing ^a   Liu, Xinping ^a   Shi, Hai ^b   Che, Honglei ^a   Wang, Weizhong ^b   Li, Fuyang ^a   Yao, Libo ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cancer; Differentiation; Myc; NDRG1; Transcriptional repression

Indexed keywords

TRICHOSTATIN A;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENE INTERACTION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; N-MYC DOWNSTREAM REGULATED GENE 1; ONCOGENE MYC; PRIORITY JOURNAL; PROMOTER REGION;

CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; GENES, REGULATOR; HELA CELLS; HISTONE DEACETYLASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION, GENETIC;

EID: 44449136357     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2008.03.002     Document Type: Article

References (33)

1. Bandyopadhyay S., et al. The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res. 638 (2003) 1731-1736
2. Bishop J.M. Retroviruses and cancer genes. Adv. Cancer Res. 37 (1982) 1-32
3. Blackwood E., and Eisenman R.N. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251 (1991) 1211-1217
4. Cangul H. Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. BMC Genet. 5 (2004) 27
5. Chen L., Peng Z., and Bateman E. In vivo interactions of the Acanthamoeba TBP gene promoter. Nucleic Acids Res. 324 (2004) 1251-1260
6. Cole M.D. The myc oncogene: its role in transformation and differentiation. Annu. Rev. Genet. 20 (1986) 361-384
7. Dang C.V. c-myc oncoprotein function. Biochim. Biophys. Acta 1072 (1991) 103-113
8. Deng Y., et al. N-Myc downstream-regulated gene 2 NDRG2 inhibits glioblastoma cell proliferation. Int. J. Cancer 106 (2003) 342-347
9. Eisenman R.N. Deconstructing Myc. Genes Dev. 15 (2001) 2023-2030
10. Facchini L.M., and Penn L.Z. Understanding the role of Myc in growth and transformation: new discoveries lead to new insights. FASEB J. 12 (1998) 633-651
11. Hu X.L., Liu X.P., Deng Y.C., and Yao L.B. Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues. Cell Tissue Res. 325 (2006) 67-76
12. Keiko Kurisaki, Akira Kurisaki, Ulrich Valcourt, Alexei A. Terentiev, Katerina Pardali, Peter ten Dijke, and Aristidis Moustakas. Nuclear factor YY1 inhibits transforming growth factor and bone morphogenetic protein-induced cell differentiation. Mol. Cell. Biol. 23 13 (2003) 4494-4510
13. Kovacevic Z., and Richardson D.R. The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer. Carcinogenesis 2712 (2006) 2355-2366
14. Kurdistani S.K., Arizti P., Reimer C.L., Sugrue M.M., Aaronson S.A., and Lee S.W. Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage. Cancer Res. 58 (1998) 4439-4444
15. Li J., and Kretzner L. The growth inhibitory Ndrg1 gene is a Myc-repressed target in human neuroblastoma and other cells overexpressing N- or c-myc. Mol. Cell. Biochem. 250 (2003) 91-105
16. Li L.H., Nerlov C., Prendergast G., MacGregor D., and Ziff E.B. c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J. 13 (1994) 4070-4079
17. Littlewood T.D., David C., Parker M.G., and Evan G. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23 (1995) 1686-1690
18. Liu N., Wang L., Liu X., Zhang J., and Yao L. Promoter methylation, mutation, and genomic deletion are involved in the decreased NDRG2 expression levels in several cancer cell lines. Biochem. Biophys. Res. Commun. 358 (2007) 164-169
19. O'Donnell K.A., Wentzel E.A., Zeller K.I., Dang C.V., and Mendell J.T. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435 (2005) 839-843
20. Okuda T., and Kondoh H. Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem. Biophys. Res. Commun. 266 (1999) 208-215
21. Qu X., et al. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. Mol. Cell. Biol. 2291-2 (2002) 35-44
22. Salnikow K., Davidson T., and Costa M. The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. Environ. Health Perspect. 110 (2002) 831-834
23. Shimono A., Okuda T., and Kondoh H. N-myc-dependent repression of Ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant. Mech. Dev. 83 (1999) 39-52
24. Stein S., Thomas E.K., Herzog B., Westfall M.D., Wang M., and Liang P. NDRG1 is necessary for p53-dependent apoptosis. J. Biol. Chem. 279 (2004) 48930-48940
25. Tsuneoka M., Koda Y., Soejima M., Teye K., and Kimura H. A novel Myc target gene, mina53, that is involved in cell proliferation. J. Biol. Chem. 277 (2002) 35450-35459
26. van Belzen N., et al. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. Lab. Invest. 77 (1997) 85-92
27. Wanzel M., Herold S., and Eilers M. Transcriptional repression by Myc. Trends Cell Biol. 13 3 (2003) 146-150
28. Wu S., et al. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 22 (2003) 351-360
29. Zhang J., et al. The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter. J. Biol. Chem. 281 (2006) 39159-39168
30. Zhang J., Liu J., Li X., and Yao L. The physical and functional interaction of NDRG2 with MSP58 in cells. Biochem. Biophys. Res. Commun. 352 (2007) 6-11
31. Zhao W., Tang R., and Huang Y. Cloning and expression pattern of the human NDRG3 gene. Biochim. Biophys. Acta 1519 (2001) 134-138
32. 2+ compounds. Cancer Res. 58 (1998) 2182-2189
33. Zhou R.H., Kokame K., Tsukamoto Y., Yutani C., Kato H., and Miyata T. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. Genomics 73 (2001) 7386-7397