Decreased levels of interleukin-10 and transforming growth factor-beta2 in cerebrospinal fluid of patients with high grade astrocytoma

Neurological Research

Volumn 30, Issue 3, 2008, Pages 294-296

  Krzyszkowski, Tadeusz ^a   Dziedzic, Tomasz ^a,b   Czepko, Ryszard ^a   Szczudlik, Andrzej ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Astrocytoma; Brain tumor; Cytokines; Immunology

Indexed keywords

INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA2;

ADULT; ARTICLE; ASTROCYTOMA; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HYDROCEPHALUS; LUMBAR DISK HERNIA; MALE; T LYMPHOCYTE; WORLD HEALTH ORGANIZATION;

ADULT; AGED; ASTROCYTOMA; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYDROCEPHALUS, NORMAL PRESSURE; INTERLEUKIN-10; INTERVERTEBRAL DISK DISPLACEMENT; LUMBOSACRAL REGION; MALE; MIDDLE AGED; TRANSFORMING GROWTH FACTOR BETA2;

EID: 44449133125     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164107X235149     Document Type: Article

References (10)

1. Dix AR, Brooks WH, Roszman TL, et al. Immune defects observed in patients with primary malignant brain tumors. J Neuroimmunol 1999; 100: 216-232
2. de Waal Malefyt R, Haanen J, Spits H, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 915-924
3. de Waal Malefyt R, Abrams J, Bennett B, et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-1220
4. Wahl SM, Swisher J, McCartney-Francis N, et al. TGF-beta: The perpetrator of immune suppression by regulatory T cells and suicidal T cells. J Leukoc Biol 2004; 76: 15-24
5. Warwick-Davies J, Lowrie DB, Cole PJ. Selective deactivation of human monocyte functions by TGF-beta. J Immunol 1995; 155: 3186-3193
6. Bodmer S, Strommer K, Frei K, et al. Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2. J Immunol 1989; 143: 3222-3229
7. Hishii M, Nitta T, Ishida H, et al. Human glioma-derived interleukin-10 inhibits antitumor immune responses in vitro. Neurosurgery 1995; 37: 1160-1166
8. Huettner C, Paulus W, Roggendorf W. Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas. Am J Pathol 1995; 146: 317-322
9. Olofsson A, Miyazono K, Kanzaki T, et al. Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes. J Biol Chem 1992; 267: 19482-19488
10. Woiciechowsky C, Asadullah K, Nestler D, et al. Diminished monocytic HLA-DR expression and ex vivo cytokine secretion capacity in patients with glioblastoma: Effect of tumor extirpation. J Neuroimmunol 1998; 84: 164-171