Characterization of virus-specific T-cell immunity in liver allograft recipients with HCV-induced cirrhosis

American Journal of Transplantation

Volumn 8, Issue 6, 2008, Pages 1214-1220

  Bharat, A ^a   Barros, F ^a   Narayanan, K ^a   Borg, B ^a   Lisker Melman, M ^a   Shenoy, S ^a   Lowell, J ^a   Crippin, J ^a   Chapman, W ^a   Mohanakumar, T ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HCV; Immunity; Liver allograft cirrhosis

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; CYTOKINE; GAMMA INTERFERON; IMMUNOSUPPRESSIVE ACID PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; PREDNISONE; RAPAMYCIN; TACROLIMUS;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CIRRHOSIS; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECIPIENT; RECURRENT DISEASE; SCORING SYSTEM; TH2 CELL;

ADULT; CYTOKINES; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INFLAMMATION; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; RECURRENCE; T-LYMPHOCYTES; TH1 CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 44449127639     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2008.02248.x     Document Type: Article

References (30)

1. Wong JB, McQuillan GM, McHutchison JG, Poynard T. Estimating future hepatitis C morbidity, mortality, and costs in the United States. Am J Public Health 2000 90 : 1562 1569.
2. Feray C, Samuel D, Thiers V et al. Reinfection of liver graft by hepatitis C virus after liver transplantation. J Clin Invest 1992 89 : 1361 1365.
3. Wright TL, Donegan E, Hsu HH et al. Recurrent and acquired hepatitis C viral infection in liver transplant recipients. Gastroenterology 1992 103 : 317 322.
4. Feray C, Gigou M, Samuel D et al. The course of hepatitis C virus infection after liver transplantation. Hepatology 1994 20 : 1137 1143.
5. Gane EJ, Naoumov NV, Qian KP et al. A longitudinal analysis of hepatitis C virus replication following liver transplantation. Gastroenterology 1996 110 : 167 177.
6. Pelletier SJ, Iezzoni JC, Crabtree TD, Hahn YS, Sawyer RG, Pruett TL. Prediction of liver allograft fibrosis after transplantation for hepatitis C virus: Persistent elevation of serum transaminase levels versus necroinflammatory activity. Liver Transpl 2000 6 : 44 53.
7. Berenguer M, Ferrell L, Watson J et al. HCV-related fibrosis progression following liver transplantation: Increase in recent years. J Hepatol 2000 32 : 673 684.
8. Charlton M, Seaberg E, Wiesner R et al. Predictors of patient and graft survival following liver transplantation for hepatitis C. Hepatology 1998 28 : 823 830.
9. Ferrari C, Valli A, Galati L et al. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepatology 1994 19 : 286 295.
10. Lechmann M, Ihlenfeldt HG, Braunschweiger I et al. T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia. Hepatology 1996 24 : 790 795.
11. Missale G, Bertoni R, Lamonaca V et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J Clin Invest 1996 98 : 706 714.
12. Sreenarasimhaiah J, Jaramillo A, Crippin J, Lisker-Melman M, Chapman WC, Mohanakumar T. Lack of optimal T-cell reactivity against the hepatitis C virus is associated with the development of fibrosis/cirrhosis during chronic hepatitis. Hum Immunol 2003 64 : 224 230.
13. Tsai SL, Liaw YF, Chen MH, Huang CY, Kuo GC. Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity. Hepatology 1997 25 : 449 458.
14. Schirren CA, Jung MC, Gerlach JT et al. Liver-derived hepatitis C virus (HCV)-specific CD4(+) T cells recognize multiple HCV epitopes and produce interferon gamma. Hepatology 2000 32 : 597 603.
15. Zekry A, Bishop GA, Bowen DG et al. Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury. Liver Transpl 2002 8 : 292 301.
16. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996 24 : 289 293.
17. Bharat A, Narayanan K, Street T et al. Early posttransplant inflammation promotes the development of alloimmunity and chronic human lung allograft rejection. Transplantation 2007 83 : 150 158.
18. Wiesner RH, Sorrell M, Villamil F. Report of the first International Liver Transplantation Society expert panel consensus conference on liver transplantation and hepatitis C. Liver Transpl 2003 9 : S1 9.
19. Chang KM, Gruener NH, Southwood S et al. Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C. J Immunol 1999 162 : 1156 1164.
20. Chang KM, Thimme R, Melpolder JJ et al. Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection. Hepatology 2001 33 : 267 276.
21. Rice CM, Walker CM. Hepatitis C virus-specific T lymphocyte responses. Curr Opin Immunol 1995 7 : 532 538.
22. Eckels DD, Wang H, Bian TH, Tabatabai N, Gill JC. Immunobiology of hepatitis C virus (HCV) infection: The role of CD4 T cells in HCV infection. Immunol Rev 2000 174 : 90 97.
23. Jacobson Brown PM, Neuman MG. Immunopathogenesis of hepatitis C viral infection: Th1/Th2 responses and the role of cytokines. Clin Biochem 2001 34 : 167 171.
24. Khan MH, Farrell GC, Byth K et al. Which patients with hepatitis C develop liver complications? Hepatology 2000 31 : 513 520.
25. Casanovas-Taltavull T, Ercilla MG, Gonzalez CP et al. Long-term immune response after liver transplantation in patients with spontaneous or post-treatment HCV-RNA clearance. Liver Transpl 2004 10 : 584 594.
26. Garcia-Retortillo M, Forns X, Feliu A et al. Hepatitis C virus kinetics during and immediately after liver transplantation. Hepatology 2002 35 : 680 687.
27. Opelz G, Sengar DP, Mickey MR, Terasaki PI. Effect of blood transfusions on subsequent kidney transplants. Transplant Proc 1973 5 : 253 259.
28. Flye MW, Burton K, Mohanakumar T et al. Donor-specific transfusions have long-term beneficial effects for human renal allografts. Transplantation 1995 60 : 1395 1401.
29. Quigley RL, Wood KJ, Morris PJ. Transfusion induces blood donor-specific suppressor cells. J Immunol 1989 142 : 463 470.
30. Bharat A, Fields RC, Mohanakumar T. Regulatory T cell-mediated transplantation tolerance. Immunol Res 2005 33 : 195 212.