Prolonged islet allograft survival in diabetic mice upon macrophage depletion by clodronate-loaded erythrocytes

Transplantation

Volumn 85, Issue 4, 2008, Pages 648-650

  Rossi, Luigia ^a   Migliavacca, Barbara ^b   Pierigé, Francesca ^a   Serafini, Sonja ^a   Sanvito, Francesca ^c   Olivieri, Stefano ^c   Nano, Rita ^c   Antonioli, Barbara ^c   Magnani, Mauro ^a   Bertuzzi, Federico ^c,d  

^a UNIVERSITY OF URBINO   (Italy)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d MEDITERRANEAN INSTITUTE FOR TRANSPLANTATION AND ADVANCED SPECIALIZED THERAPIES ISMETT   (Italy)

Author keywords

Clodronate; Inflammation; Islet transplantation; Macrophages

Indexed keywords

BONE DENSITY CONSERVATION AGENT; CLODRONIC ACID;

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C57BL MOUSE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GRAFT SURVIVAL; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; MACROPHAGE; METHODOLOGY; MOUSE; PANCREAS ISLET TRANSPLANTATION; PHYSIOLOGY; TIME;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; CLODRONIC ACID; DIABETES MELLITUS, EXPERIMENTAL; GRAFT SURVIVAL; IMMUNOSUPPRESSION; ISLETS OF LANGERHANS TRANSPLANTATION; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 44449126730     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31816360f3     Document Type: Article

References (24)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230.
2. Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006; 355: 1318.
3. Poggioli R, Faradji RN, Ponte G, et al. Quality of life after islet transplantation. Am J Transplant 2006; 6: 371.
4. Toso C, Shapiro AM, Bowker S, et al. Quality of life after islet transplant: Impact of the number of islet infusions and metabolic outcome. Transplantation 2007; 84: 664.
5. Kaufman DB, Platt JL, Rabe FL, et al. Differential roles of Mac-1+cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts. J Exp Med 1990; 172: 291.
6. Bottino R, Fernandez LA, Ricordi C, et al. Transplantation of allogeneic islets of Langerhans in the rat liver. Effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 1998; 47: 316.
7. Piemonti L, Leone BE, Nano R, et al. Human pancreatic islets produce and secrete MCP-1: Relevance in human islet transplantation. Diabetes 2002; 51: 55.
8. Andres A, Toso C, Morel P, et al. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. Transplantation 2005; 79: 543.
9. Omer A, Keegan M, Czismadia E, et al. Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation 2003; 10: 240.
10. Rossi L, Serafini S, Antonelli A, et al. Macrophage depletion induced by clodronate-loaded erythrocytes. J Drug Target 2005; 13: 99.
11. Rossi L, Brandi G, Schiavano GF, et al. Heterodimer-loaded erythrocytes as bioreactors for slow delivery of the antiviral drug azidothymidine and the antimycobacterial drug ethambutol. AIDS Res Hum Retroviruses 1999; 15: 345.
12. Fraternale A, Rossi L, Magnani M. Encapsulation, metabolism and release of 2-fluoro-ara-AMP from human erythrocytes. Biochim Biophys Acta 1996; 1291: 149.
13. Rossi L, Castro M, D'Orio F, et al. Low doses of dexamethasone constantly delivered by autologous erythrocytes slow the progression of lung disease in cystic fibrosis patients. Blood Cell Mol Dis 2004a; 33: 57.
14. Annese V, Latiano A, Rossi L, et al. Erythrocytes-mediated delivery of dexamethasone in steroid-dependent IBD patients-a pilot uncontrolled study. Am J Gastroenterol 2005; 100: 1370.
15. Magnani M, Rossi L, Fraternale A, et al. Erythrocyte-mediated delivery of drugs, peptides and modified oligonucleotides. Gene Ther 2002a; 9: 749.
16. Rossi L, Serafini S, Cenerini L, et al. Erythrocyte-mediated delivery of dexamethasone in patients with chronic obstructive pulmonary disease. Biotechnol Appl Biochem 2001a; 33: 85.
17. Magnani M, Rossi L, Brandi G, et al. Targeting antiretroviral nucleoside analogues in phosphorylated form to macrophages: In vitro and in vivo studies. Proc Natl Acad Sci 1992; 89: 6477.
18. Magnani M, Rossi L, Fraternale A, et al. Targeting antiviral nucleotide analogues to macrophages. J Leukocyte Biol 1997; 62: 133.
19. Rossi L, Serafini S, Cappellacci L, et al. Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus. J Antimicrob Chemother 2001b; 47: 819.
20. Melzi R, Battaglia M, Draghici E, et al. Relevance of the hyperglycemia on the timing of functional loss of allogeneic islet transplants: Implication for mouse model. Transplantation 2007; 83: 167.
21. Ozasa T, Newton MR, Dallman MJ, et al. Cytokine gene expression in pancreatic islet grafts in the rat. Transplantation 1997; 64: 1152.
22. Molano RD, Pileggi A, Berney T, et al. Prolonged islet allograft survival in diabeticNODmice by targeting CD45RB and CD154. Diabetes 2003; 52: 957.
23. Yasunami Y, Kojo S, Kitamura H, et al. Vα14 NKT cell-triggered IFN- γ production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets. J Exp Med 2005; 202: 913.
24. Marselli L, Dotta F, Piro S, et al. Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines. J Clin Endocrinol Metab 2001; 86: 4974.