Reduced susceptibility to tetracyclines is associated in vitro with the presence of 16S rRNA mutations in Mycoplasma hominis and Mycoplasma pneumoniae

Journal of Antimicrobial Chemotherapy

Volumn 61, Issue 6, 2008, Pages 1390-1392

  Degrange S ^a   Renaudin, H ^a   Charron, A ^a   Pereyre, S ^a   Bebear C ^a   Bébéar, Cecile M ^a  

^a Univ Victor Segalen Bordeaux 2   (France)

Author keywords

Human mycoplasmas; Ribosomal mutations; Tetracycline resistance

Indexed keywords

DOXYCYCLINE; GENOMIC DNA; MINOCYCLINE; RIBOSOME RNA; RNA 16S; TETRACYCLINE; TETRACYCLINE DERIVATIVE;

AGAR MEDIUM; ANTIBIOTIC SENSITIVITY; BACTERIAL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE TECHNIQUE; FRAGMENTATION REACTION; GENE AMPLIFICATION; GENE MUTATION; IN VITRO STUDY; INVERSE POLYMERASE CHAIN REACTION; LETTER; MINIMUM INHIBITORY CONCENTRATION; MYCOPLASMA HOMINIS; MYCOPLASMA PNEUMONIA; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; STRAIN IDENTIFICATION;

DNA MUTATIONAL ANALYSIS; DNA, BACTERIAL; DNA, RIBOSOMAL; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; MYCOPLASMA HOMINIS; MYCOPLASMA PNEUMONIAE; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; TETRACYCLINE RESISTANCE;

EID: 44449124551     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkn118     Document Type: Letter

References (6)

1. Bébéar CM, Kempf I. Antimicrobial therapy and antimicrobial resistance. In: Blanchard A, Browning GF, eds. Mycoplasmas: Pathogenesis, Molecular Biology, and Emerging Strategies for Control. Wymondham: Horizon Bioscience, 2005; 535-68.
2. Trieber CA, Taylor DE. Mutations in the 16S rRNA genes of Helicobacter pylori mediate resistance to tetracycline. J Bacteriol 2002; 184: 2131-40.
3. Waites KB, Bébéar CM, Roberston JA et al. In: Nolte FS, Coordinating ed. Cumited 34, Laboratory Diagnosis of Mycoplasmal Infections. Washington, DC: American Society for Microbiology, 2001.
4. Gruson D, Pereyre S, Renaudin H et al. In vitro development of resistance to six and four fluoroquinolones in Mycoplasma pneumoniae and Mycoplasma hominis, respectively. Antimicrob Agents Chemother 2005; 49: 1190-3.
5. Dégrange S, Renaudin H, Charron A et al. Tetracycline resistance in Ureaplasma spp. and in Mycoplasma hominis: prevalence in Bordeaux, France, from 1999 to 2002 and description of two tet(M)-positive isolates of M. hominis susceptible to tetracyclines. Antimicrob Agents Chemother 2008; 52: 742-4.
6. Pioletti M, Schlunzen F, Harms J et al. Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J 2001; 20: 1829-39.