메뉴 건너뛰기




Volumn 68, Issue 2, 2008, Pages 129-134

Polymorphism in CYP11α and CYP17 genes and the etiology of hyperandrogenism in patients with polycystic ovary syndrome;Polimorfismos en los genes CYP11α y CYP17 y etiologia del hiperandrogenismo en pacientes con poliquistosis ovarica

Author keywords

Androgens; Genetic polymorphism; Polycystic ovary syndrome

Indexed keywords

ANDROGEN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 17; TESTOSTERONE; STEROID 17ALPHA MONOOXYGENASE;

EID: 44449113753     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (21)

References (17)
  • 2
    • 0033587746 scopus 로고    scopus 로고
    • Thirty seven genes for polycystic ovary syndrome: Strongest evidence for linkage is with folistatin
    • Urbanek M, Legro RS, Driscoll DA, et al. Thirty seven genes for polycystic ovary syndrome: strongest evidence for linkage is with folistatin. Proc Natl Acad Sci USA 1999; 96: 8573-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8573-8578
    • Urbanek, M.1    Legro, R.S.2    Driscoll, D.A.3
  • 3
    • 0032566950 scopus 로고    scopus 로고
    • Role of cytochrome P450c17 in polycystic ovary syndrome
    • Qin KN. Rosenfield RL. Role of cytochrome P450c17 in polycystic ovary syndrome. Mol Cell Endocrinol 1998; 145: 111-21.
    • (1998) Mol Cell Endocrinol , vol.145 , pp. 111-121
    • Qin, K.N.1    Rosenfield, R.L.2
  • 4
    • 3342995097 scopus 로고    scopus 로고
    • Wood JR, Ho CK, Nelson-Degrave VL, McAllister JM, Strauss JF 3rd. The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling. J Reprod Immunol 2004; 63: 51-60.
    • Wood JR, Ho CK, Nelson-Degrave VL, McAllister JM, Strauss JF 3rd. The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling. J Reprod Immunol 2004; 63: 51-60.
  • 5
    • 0033304623 scopus 로고    scopus 로고
    • Augmented androgens production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries
    • Nelson VL, Legro RS, Strauss JF, et al. Augmented androgens production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Mol Endo 1999; 13: 6946-57.
    • (1999) Mol Endo , vol.13 , pp. 6946-6957
    • Nelson, V.L.1    Legro, R.S.2    Strauss, J.F.3
  • 6
    • 0028024363 scopus 로고
    • Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17
    • Carey AH, Waterworth D, Patel K, et al. Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17. Hum Mol Gen 1994; 3: 1873-6.
    • (1994) Hum Mol Gen , vol.3 , pp. 1873-1876
    • Carey, A.H.1    Waterworth, D.2    Patel, K.3
  • 7
    • 0031049755 scopus 로고    scopus 로고
    • Association of the steroid synthesis gene CYP11α with polycystic ovary syndrome and hyperandrogenism
    • Gharani N, Waterworth DM, Batty S, et al. Association of the steroid synthesis gene CYP11α with polycystic ovary syndrome and hyperandrogenism. Hum Mol Gen 1997; 6: 397-402.
    • (1997) Hum Mol Gen , vol.6 , pp. 397-402
    • Gharani, N.1    Waterworth, D.M.2    Batty, S.3
  • 8
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997; 18: 774-800.
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 9
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989; 38: 1165-74.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 10
    • 0025195368 scopus 로고
    • Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome
    • Rosenfield RL, Barnes RB, Cara JF, Lucky AW. Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome. Fertil Steril 1990; 53: 785-91.
    • (1990) Fertil Steril , vol.53 , pp. 785-791
    • Rosenfield, R.L.1    Barnes, R.B.2    Cara, J.F.3    Lucky, A.W.4
  • 11
    • 0034457443 scopus 로고    scopus 로고
    • Differential activity of the cytochrome P450 17α hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells
    • Wickenheisser JK, Quinn PG, Nelson VL, Legro RS, Strauss JF 3rd McAllister JM. Differential activity of the cytochrome P450 17α hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells. J Clin Endocrinol Metab 2000; 58: 2304-11.
    • (2000) J Clin Endocrinol Metab , vol.58 , pp. 2304-2311
    • Wickenheisser, J.K.1    Quinn, P.G.2    Nelson, V.L.3    Legro, R.S.4    Strauss 3rd, J.F.5    McAllister, J.M.6
  • 12
    • 0033304623 scopus 로고    scopus 로고
    • Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries
    • Nelson VL, Legro RS, Strauss III JF, McAllister JM. Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Mol Endocrinol 1999; 13: 946-57.
    • (1999) Mol Endocrinol , vol.13 , pp. 946-957
    • Nelson, V.L.1    Legro, R.S.2    Strauss III, J.F.3    McAllister, J.M.4
  • 13
    • 0036147995 scopus 로고    scopus 로고
    • Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side chain cleavage and 17alpha hydroxylase/C (17-20) lyase promoters
    • Daneshmand S, Weitsman SR, Navab A, Jakimiuk AJ, Magoffin DA. Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side chain cleavage and 17alpha hydroxylase/C (17-20) lyase promoters. Fert Steril 2002; 77: 274-80.
    • (2002) Fert Steril , vol.77 , pp. 274-280
    • Daneshmand, S.1    Weitsman, S.R.2    Navab, A.3    Jakimiuk, A.J.4    Magoffin, D.A.5
  • 14
    • 0035059718 scopus 로고    scopus 로고
    • Role of the pentanucleotide (tttta), polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism
    • San Millan JL, Sancho J, Calvo RM, Escobar Morreale HF. Role of the pentanucleotide (tttta), polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism. Fert Steril 2001; 75: 797-802.
    • (2001) Fert Steril , vol.75 , pp. 797-802
    • San Millan, J.L.1    Sancho, J.2    Calvo, R.M.3    Escobar Morreale, H.F.4
  • 15
    • 0028920022 scopus 로고
    • Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp(a)in plasma
    • Mooser V, Mancini FP, Bopp S, et al. Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp(a)in plasma. Hum Mol Genet 1995; 4: 173-81.
    • (1995) Hum Mol Genet , vol.4 , pp. 173-181
    • Mooser, V.1    Mancini, F.P.2    Bopp, S.3
  • 16
    • 16044372273 scopus 로고    scopus 로고
    • 5′Polymorphism of the CYP17 gene is not associated with serum testosterone levels in women with polycystic ovary
    • Gharani N, Waterworth DM, Williamson R, Franks S. 5′Polymorphism of the CYP17 gene is not associated with serum testosterone levels in women with polycystic ovary. J Clin Endocrinol Metab 1996; 81: 4174.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4174
    • Gharani, N.1    Waterworth, D.M.2    Williamson, R.3    Franks, S.4
  • 17
    • 0034061052 scopus 로고    scopus 로고
    • Microsatellite polymorphism (tttta)n at -528base pairs of gene CYP11α influences hyperandrogenemia in patients with polycystic ovary syndrome
    • Diamanti-Kandarakis E, Bartzis MI, Bergiele AT, Tsianatelli TC, Kouli CR. Microsatellite polymorphism (tttta)n at -528base pairs of gene CYP11α influences hyperandrogenemia in patients with polycystic ovary syndrome. Fert Ster 2000; 73: 735-41.
    • (2000) Fert Ster , vol.73 , pp. 735-741
    • Diamanti-Kandarakis, E.1    Bartzis, M.I.2    Bergiele, A.T.3    Tsianatelli, T.C.4    Kouli, C.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.